New evidence for an association between the CSF HVA:5-HIAA ratio and psychopathic traits
(2003) In Journal of Neurology, Neurosurgery and Psychiatry 74(7). p.918-921- Abstract
- OBJECTIVES: To replicate the relation between the CSF HVA:5-HIAA ratio and psychopathic traits previously reported in a pilot group of 22 perpetrators of violent crimes. METHODS: CSF monoamine metabolite concentrations in another 28 violent and sexual offenders, aged 45 or below, referred to pretrial forensic psychiatric investigation, were compared to features of psychopathy according to the Psychopathy Checklist-Revised (PCL-R). RESULTS: Our previous finding was repeated in the new study group, where the HVA:5-HIAA ratio was strongly associated with psychopathic traits (r = 0.50, p = 0.010), particularly its behavioural aspects (r = 0.523, p = 0.004). In subsamples of individuals from both study groups who had no medication (n = 25) or... (More)
- OBJECTIVES: To replicate the relation between the CSF HVA:5-HIAA ratio and psychopathic traits previously reported in a pilot group of 22 perpetrators of violent crimes. METHODS: CSF monoamine metabolite concentrations in another 28 violent and sexual offenders, aged 45 or below, referred to pretrial forensic psychiatric investigation, were compared to features of psychopathy according to the Psychopathy Checklist-Revised (PCL-R). RESULTS: Our previous finding was repeated in the new study group, where the HVA:5-HIAA ratio was strongly associated with psychopathic traits (r = 0.50, p = 0.010), particularly its behavioural aspects (r = 0.523, p = 0.004). In subsamples of individuals from both study groups who had no medication (n = 25) or no current axis I disorder, including a history of mood disorder or substance dependence (n = 21), the HVA:5-HIAA ratio remained strongly associated with all psychopathy factors but most closely with the behavioural features. Retrospective assessments of childhood disruptive symptomatology, such as attention deficit hyperactivity disorder or conduct disorder, analysed in relation to the monoamine metabolites, showed the same association with the HVA:5-HIAA ratio. CONCLUSIONS: Violent and aggressive behavioural traits with childhood onset and adult expression as psychopathic features are associated with changed activity in the brain dopaminergic system, possibly as a result of serotonergic dysregulation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1126669
- author
- Anckarsäter, Henrik LU ; Blennow, Kaj LU ; Sjodin, A-K and Forsman, A
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- catecholamine, monoamine, violence, conduct disorder, ADHD, PCL-R
- in
- Journal of Neurology, Neurosurgery and Psychiatry
- volume
- 74
- issue
- 7
- pages
- 918 - 921
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:12810780
- scopus:0038480246
- ISSN
- 1468-330X
- DOI
- 10.1136/jnnp.74.7.918
- language
- English
- LU publication?
- yes
- id
- e46643f4-a74f-4003-b97c-bf3fe9ae0f2e (old id 1126669)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/12810780
- http://jnnp.bmj.com/content/74/7/918.long
- date added to LUP
- 2016-04-01 17:08:07
- date last changed
- 2022-05-08 23:06:39
@article{e46643f4-a74f-4003-b97c-bf3fe9ae0f2e,
abstract = {{OBJECTIVES: To replicate the relation between the CSF HVA:5-HIAA ratio and psychopathic traits previously reported in a pilot group of 22 perpetrators of violent crimes. METHODS: CSF monoamine metabolite concentrations in another 28 violent and sexual offenders, aged 45 or below, referred to pretrial forensic psychiatric investigation, were compared to features of psychopathy according to the Psychopathy Checklist-Revised (PCL-R). RESULTS: Our previous finding was repeated in the new study group, where the HVA:5-HIAA ratio was strongly associated with psychopathic traits (r = 0.50, p = 0.010), particularly its behavioural aspects (r = 0.523, p = 0.004). In subsamples of individuals from both study groups who had no medication (n = 25) or no current axis I disorder, including a history of mood disorder or substance dependence (n = 21), the HVA:5-HIAA ratio remained strongly associated with all psychopathy factors but most closely with the behavioural features. Retrospective assessments of childhood disruptive symptomatology, such as attention deficit hyperactivity disorder or conduct disorder, analysed in relation to the monoamine metabolites, showed the same association with the HVA:5-HIAA ratio. CONCLUSIONS: Violent and aggressive behavioural traits with childhood onset and adult expression as psychopathic features are associated with changed activity in the brain dopaminergic system, possibly as a result of serotonergic dysregulation.}},
author = {{Anckarsäter, Henrik and Blennow, Kaj and Sjodin, A-K and Forsman, A}},
issn = {{1468-330X}},
keywords = {{catecholamine; monoamine; violence; conduct disorder; ADHD; PCL-R}},
language = {{eng}},
number = {{7}},
pages = {{918--921}},
publisher = {{BMJ Publishing Group}},
series = {{Journal of Neurology, Neurosurgery and Psychiatry}},
title = {{New evidence for an association between the CSF HVA:5-HIAA ratio and psychopathic traits}},
url = {{http://dx.doi.org/10.1136/jnnp.74.7.918}},
doi = {{10.1136/jnnp.74.7.918}},
volume = {{74}},
year = {{2003}},
}