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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Justice, Anne E ; Franks, Paul LU ; North, Kari E and Lindgren, Cecilia M (2019) In Nature Genetics 51. p.452-469
Abstract
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF
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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
51
pages
452 - 469
publisher
Nature Publishing Group
external identifiers
  • scopus:85061697378
  • pmid:30778226
ISSN
1546-1718
DOI
10.1038/s41588-018-0334-2
language
English
LU publication?
yes
id
e480e762-4ec0-490f-8de5-8201f81cca66
date added to LUP
2019-03-05 12:10:49
date last changed
2020-02-23 07:51:58
@article{e480e762-4ec0-490f-8de5-8201f81cca66,
  abstract     = {Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF },
  author       = {Justice, Anne E and Franks, Paul and North, Kari E and Lindgren, Cecilia M},
  issn         = {1546-1718},
  language     = {eng},
  pages        = {452--469},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution},
  url          = {http://dx.doi.org/10.1038/s41588-018-0334-2},
  doi          = {10.1038/s41588-018-0334-2},
  volume       = {51},
  year         = {2019},
}