Advanced

Mitochondria and the Brain : Bioenergetics and Beyond

Belenguer, Pascale ; Duarte, João M.N. LU ; Schuck, Patrícia F. and Ferreira, Gustavo C. (2019) In Neurotoxicity Research 36(2). p.219-238
Abstract

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of... (More)

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain metabolism, Mitochondria, MRS, Neurogenesis
in
Neurotoxicity Research
volume
36
issue
2
pages
219 - 238
publisher
Springer
external identifiers
  • scopus:85066479216
ISSN
1029-8428
DOI
10.1007/s12640-019-00061-7
language
English
LU publication?
yes
id
e4d80061-c1cf-4d9c-ae6f-9f13ade39a9d
date added to LUP
2019-06-25 12:11:56
date last changed
2019-12-03 02:14:21
@article{e4d80061-c1cf-4d9c-ae6f-9f13ade39a9d,
  abstract     = {<p>The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.</p>},
  author       = {Belenguer, Pascale and Duarte, João M.N. and Schuck, Patrícia F. and Ferreira, Gustavo C.},
  issn         = {1029-8428},
  language     = {eng},
  month        = {06},
  number       = {2},
  pages        = {219--238},
  publisher    = {Springer},
  series       = {Neurotoxicity Research},
  title        = {Mitochondria and the Brain : Bioenergetics and Beyond},
  url          = {http://dx.doi.org/10.1007/s12640-019-00061-7},
  doi          = {10.1007/s12640-019-00061-7},
  volume       = {36},
  year         = {2019},
}