Adrenal incidentaloma - follow-up results from a Swedish prospective study
(2006) In European Journal of Endocrinology 154(3). p.419-423- Abstract
- Objectives: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. Design: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. Methods: Diagnostic procedures were undertaken according to a protocol including reinvestigation with Computed tomography scans after 3-6 months. 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after... (More)
- Objectives: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. Design: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. Methods: Diagnostic procedures were undertaken according to a protocol including reinvestigation with Computed tomography scans after 3-6 months. 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after 27-30 months of follow-up. Operation was recommended when the incidentaloma size increased or if there was a suspicion of a hypersecreting tumour. Results: The median age at diagnosis of the 229 patients included in the follow-up study was 64 years (range 28-84 years) and the median size of the adrenal incidentalomas when discovered was 2.5 cm (range 1-8 cm). During the follow-up period, an increase in incidentaloma size of >= 0.5 cm was reported in 17 (7.4%) and of >= 1.0 cm was reported in 12 (5.2%,) of the 229 patients. A decrease in size was seen in 12 patients (5.2%). A hypersecreting tumour was found in 2%, of the hormonally investigated patients: Cushing's syndrome (n = 2) and phaeochromocytoma (n = 1). Eleven patients underwent adrenalectomy, but no cases of primary adrenal malignancy were observed. Conclusions: Patients with adrenal incidentaloma had a low risk of developing malignancy or hormonal hypersecretion during a short-term follow-up period. (Less)
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https://lup.lub.lu.se/record/410847
- author
- Bulow, B ; Jansson, S ; Juhlin, C ; Steen, L ; Thoren, M ; Wahrenberg, L ; Valdemarsson, Stig LU ; Wangberg, B and Ahrén, Bo LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Endocrinology
- volume
- 154
- issue
- 3
- pages
- 419 - 423
- publisher
- Society of the European Journal of Endocrinology
- external identifiers
-
- wos:000237134500009
- pmid:16498055
- scopus:33645235494
- ISSN
- 1479-683X
- DOI
- 10.1530/eje.1.02110
- language
- English
- LU publication?
- yes
- id
- e4fada32-0866-4d28-86b3-1ed30d758986 (old id 410847)
- date added to LUP
- 2016-04-01 12:12:32
- date last changed
- 2024-02-07 00:49:24
@article{e4fada32-0866-4d28-86b3-1ed30d758986,
abstract = {{Objectives: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. Design: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. Methods: Diagnostic procedures were undertaken according to a protocol including reinvestigation with Computed tomography scans after 3-6 months. 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after 27-30 months of follow-up. Operation was recommended when the incidentaloma size increased or if there was a suspicion of a hypersecreting tumour. Results: The median age at diagnosis of the 229 patients included in the follow-up study was 64 years (range 28-84 years) and the median size of the adrenal incidentalomas when discovered was 2.5 cm (range 1-8 cm). During the follow-up period, an increase in incidentaloma size of >= 0.5 cm was reported in 17 (7.4%) and of >= 1.0 cm was reported in 12 (5.2%,) of the 229 patients. A decrease in size was seen in 12 patients (5.2%). A hypersecreting tumour was found in 2%, of the hormonally investigated patients: Cushing's syndrome (n = 2) and phaeochromocytoma (n = 1). Eleven patients underwent adrenalectomy, but no cases of primary adrenal malignancy were observed. Conclusions: Patients with adrenal incidentaloma had a low risk of developing malignancy or hormonal hypersecretion during a short-term follow-up period.}},
author = {{Bulow, B and Jansson, S and Juhlin, C and Steen, L and Thoren, M and Wahrenberg, L and Valdemarsson, Stig and Wangberg, B and Ahrén, Bo}},
issn = {{1479-683X}},
language = {{eng}},
number = {{3}},
pages = {{419--423}},
publisher = {{Society of the European Journal of Endocrinology}},
series = {{European Journal of Endocrinology}},
title = {{Adrenal incidentaloma - follow-up results from a Swedish prospective study}},
url = {{http://dx.doi.org/10.1530/eje.1.02110}},
doi = {{10.1530/eje.1.02110}},
volume = {{154}},
year = {{2006}},
}