Ethanol exposure increases expression of c-jun and junD in human neuroblastoma cells
(1996) In NeuroReport 7(13). p.2191-2195- Abstract
- The aim of this study was to investigate the effect of ethanol exposure on the expression of fos and jun genes. Exposure of human neuroblastoma SH-SY5Y cells to ethanol for 2-4 days caused a dose-dependent increase in c-jun and junD mRNA levels, whereas mRNAs for c-fos, fosB and junB were not detectable in control or ethanol-treated cells. Four days of ethanol exposure also enhanced the AP-1 binding activity. Experiments with actinomycin D demonstrated that ethanol did not influence the degradation of c-jun and junD mRNAs. These results demonstrate that long-term exposure to ethanol increases c-jun and junD expression. This effect may be one of the mechanisms through which ethanol influences the gene regulatory system in neuronal cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109864
- author
- Ding, Wei-Qun ; Larsson, Christer LU and Alling, Christer LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- in
- NeuroReport
- volume
- 7
- issue
- 13
- pages
- 2191 - 2195
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:8930987
- scopus:0029807746
- ISSN
- 1473-558X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Tumour Cell Biology (013017530)
- id
- e50eca0f-bd2c-456a-b108-7875b2f17738 (old id 1109864)
- date added to LUP
- 2016-04-01 12:24:44
- date last changed
- 2022-01-27 03:21:58
@article{e50eca0f-bd2c-456a-b108-7875b2f17738, abstract = {{The aim of this study was to investigate the effect of ethanol exposure on the expression of fos and jun genes. Exposure of human neuroblastoma SH-SY5Y cells to ethanol for 2-4 days caused a dose-dependent increase in c-jun and junD mRNA levels, whereas mRNAs for c-fos, fosB and junB were not detectable in control or ethanol-treated cells. Four days of ethanol exposure also enhanced the AP-1 binding activity. Experiments with actinomycin D demonstrated that ethanol did not influence the degradation of c-jun and junD mRNAs. These results demonstrate that long-term exposure to ethanol increases c-jun and junD expression. This effect may be one of the mechanisms through which ethanol influences the gene regulatory system in neuronal cells.}}, author = {{Ding, Wei-Qun and Larsson, Christer and Alling, Christer}}, issn = {{1473-558X}}, language = {{eng}}, number = {{13}}, pages = {{2191--2195}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{NeuroReport}}, title = {{Ethanol exposure increases expression of c-jun and junD in human neuroblastoma cells}}, volume = {{7}}, year = {{1996}}, }