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Familial Aggregation of Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia with Solid Tumors and Myeloid Malignancies

Kristinsson, Sigurdur Y. ; Goldin, Lynn R. ; Turesson, Ingemar LU ; Bjorkholm, Magnus and Landgren, Ola (2012) In Acta Haematologica 127(3). p.173-177
Abstract
Lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year. Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients. Copyright... (More)
Lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year. Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients. Copyright (C) 2012 S. Karger AG, Basel (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmunity, Familial aggregation, Hematological malignancies, Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia, Monoclonal, gammopathy of undetermined significance, Solid tumors, Susceptibility
in
Acta Haematologica
volume
127
issue
3
pages
173 - 177
publisher
Karger
external identifiers
  • wos:000302205200009
  • scopus:84856588322
  • pmid:22310551
ISSN
1421-9662
DOI
10.1159/000335618
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
id
e57e243d-9ab3-4d9d-8fd0-ae6b5ed7fcda (old id 2594577)
date added to LUP
2016-04-01 09:56:00
date last changed
2022-04-27 08:57:45
@article{e57e243d-9ab3-4d9d-8fd0-ae6b5ed7fcda,
  abstract     = {{Lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year. Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients. Copyright (C) 2012 S. Karger AG, Basel}},
  author       = {{Kristinsson, Sigurdur Y. and Goldin, Lynn R. and Turesson, Ingemar and Bjorkholm, Magnus and Landgren, Ola}},
  issn         = {{1421-9662}},
  keywords     = {{Autoimmunity; Familial aggregation; Hematological malignancies; Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia; Monoclonal; gammopathy of undetermined significance; Solid tumors; Susceptibility}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{173--177}},
  publisher    = {{Karger}},
  series       = {{Acta Haematologica}},
  title        = {{Familial Aggregation of Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia with Solid Tumors and Myeloid Malignancies}},
  url          = {{https://lup.lub.lu.se/search/files/1401153/3128449.pdf}},
  doi          = {{10.1159/000335618}},
  volume       = {{127}},
  year         = {{2012}},
}