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Clinical characteristics of asymptomatic left ventricular diastolic dysfunction and its association with self-rated health and N-terminal B-type natriuretic peptide : a cross-sectional study

Ahmadi, Nasser S ; Bennet, Louise LU orcid ; Larsson, Charlotte A LU ; Andersson, Susanne ; Månsson, Jörgen and Lindblad, Ulf (2016) In ESC Heart Failure 3(3). p.205-211
Abstract

AIMS: Left ventricular hypertrophy, obesity, hypertension, and N-terminal B-type natriuretic peptide (Nt-proBNP) predict left ventricular diastolic dysfunction with preserved systolic function (DD-PSF). Self-rated health (SRH) is shown to be associated with chronic diseases, but the association of SRH with DD-PSF is unclear. In light of the clinical implications of DD-PSF, the following goals are of considerable importance: (1) to determine the role of SRH in patients with DD-PSF in the general population and (2) to study the association between Nt-proBNP and DD-PSF.

METHODS AND RESULTS: The current study is a cross-sectional study conducted on a random sampling of a rural population. Individuals 30-75 years of age were... (More)

AIMS: Left ventricular hypertrophy, obesity, hypertension, and N-terminal B-type natriuretic peptide (Nt-proBNP) predict left ventricular diastolic dysfunction with preserved systolic function (DD-PSF). Self-rated health (SRH) is shown to be associated with chronic diseases, but the association of SRH with DD-PSF is unclear. In light of the clinical implications of DD-PSF, the following goals are of considerable importance: (1) to determine the role of SRH in patients with DD-PSF in the general population and (2) to study the association between Nt-proBNP and DD-PSF.

METHODS AND RESULTS: The current study is a cross-sectional study conducted on a random sampling of a rural population. Individuals 30-75 years of age were consecutively subjected to conventional echocardiography and tissue velocity imaging. Data were collected on 500 (48%) men and 538 (52%) women (n = 1038). DD-PSF was the main outcome, and SRH and Nt-proBNP were the primary indicators. Diabetes mellitus, hypertension, and obesity were accounted for as major confounders of the association with SRH. DD-PSF was identified in 137 individuals, namely, 79 men (15.8%) and 58 women (10.8%). In a multivariate regression model, SRH (OR 2.95; 95% CI 1.02-8.57) and Nt-proBNP (quartile 4 vs. quartile 1 OR 4.23; 95% CI 1.74-10.26) were both independently associated with DD-PSF.

CONCLUSIONS: SRH, evaluated based on a descriptive question on general health, should be included in the diagnostic process of DD-PSF. In agreement with previous studies, our study confirms that Nt-proBNP is a major indicator of DD-PSF.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
ESC Heart Failure
volume
3
issue
3
pages
7 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:27818785
  • wos:000381755300008
  • scopus:85052883537
ISSN
2055-5822
DOI
10.1002/ehf2.12090
language
English
LU publication?
yes
id
e58b3b8b-3899-48dc-b53b-ca1d3ab7ab45
date added to LUP
2017-08-28 17:30:04
date last changed
2025-10-14 11:39:39
@article{e58b3b8b-3899-48dc-b53b-ca1d3ab7ab45,
  abstract     = {{<p>AIMS: Left ventricular hypertrophy, obesity, hypertension, and N-terminal B-type natriuretic peptide (Nt-proBNP) predict left ventricular diastolic dysfunction with preserved systolic function (DD-PSF). Self-rated health (SRH) is shown to be associated with chronic diseases, but the association of SRH with DD-PSF is unclear. In light of the clinical implications of DD-PSF, the following goals are of considerable importance: (1) to determine the role of SRH in patients with DD-PSF in the general population and (2) to study the association between Nt-proBNP and DD-PSF.</p><p>METHODS AND RESULTS: The current study is a cross-sectional study conducted on a random sampling of a rural population. Individuals 30-75 years of age were consecutively subjected to conventional echocardiography and tissue velocity imaging. Data were collected on 500 (48%) men and 538 (52%) women (n = 1038). DD-PSF was the main outcome, and SRH and Nt-proBNP were the primary indicators. Diabetes mellitus, hypertension, and obesity were accounted for as major confounders of the association with SRH. DD-PSF was identified in 137 individuals, namely, 79 men (15.8%) and 58 women (10.8%). In a multivariate regression model, SRH (OR 2.95; 95% CI 1.02-8.57) and Nt-proBNP (quartile 4 vs. quartile 1 OR 4.23; 95% CI 1.74-10.26) were both independently associated with DD-PSF.</p><p>CONCLUSIONS: SRH, evaluated based on a descriptive question on general health, should be included in the diagnostic process of DD-PSF. In agreement with previous studies, our study confirms that Nt-proBNP is a major indicator of DD-PSF.</p>}},
  author       = {{Ahmadi, Nasser S and Bennet, Louise and Larsson, Charlotte A and Andersson, Susanne and Månsson, Jörgen and Lindblad, Ulf}},
  issn         = {{2055-5822}},
  keywords     = {{Journal Article}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{205--211}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{ESC Heart Failure}},
  title        = {{Clinical characteristics of asymptomatic left ventricular diastolic dysfunction and its association with self-rated health and N-terminal B-type natriuretic peptide : a cross-sectional study}},
  url          = {{http://dx.doi.org/10.1002/ehf2.12090}},
  doi          = {{10.1002/ehf2.12090}},
  volume       = {{3}},
  year         = {{2016}},
}