Hög tid att pröva hypotermi i behandlingen av slaganfall
(2001) In Läkartidningen 98(18). p.2172-2175- Abstract
- There is a revived clinical interest in hypothermia as a neuroprotective intervention in brain ischemia. This originates from the experimental finding that hypothermia of only 3 degrees C-4 degrees C below normal body temperature completely abolishes neuronal damage from an ischemic insult that is lethal in normothermia. The idea that hypothermia protects cells from ischemic damage mainly by lowering metabolic rate is challenged. We propose that detrimental protein-lipid interactions in brain cells, that are activated during and following brain ischemia and that mediate adverse cellular signaling and lead to cell death, are blunted or prevented by mild hypothermia.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122708
- author
- Wieloch, Tadeusz LU and Boris-Möller, Fredrik LU
- organization
- alternative title
- [High time to test hypothermia in the treatment of stroke]
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 98
- issue
- 18
- pages
- 2172 - 2175
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:11402595
- scopus:0035795824
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)
- id
- e5a17457-9d37-4d67-82d3-160e5f8744c1 (old id 1122708)
- alternative location
- http://ltarkiv.lakartidningen.se/artNo22894
- date added to LUP
- 2016-04-01 16:17:38
- date last changed
- 2022-01-28 18:39:30
@article{e5a17457-9d37-4d67-82d3-160e5f8744c1, abstract = {{There is a revived clinical interest in hypothermia as a neuroprotective intervention in brain ischemia. This originates from the experimental finding that hypothermia of only 3 degrees C-4 degrees C below normal body temperature completely abolishes neuronal damage from an ischemic insult that is lethal in normothermia. The idea that hypothermia protects cells from ischemic damage mainly by lowering metabolic rate is challenged. We propose that detrimental protein-lipid interactions in brain cells, that are activated during and following brain ischemia and that mediate adverse cellular signaling and lead to cell death, are blunted or prevented by mild hypothermia.}}, author = {{Wieloch, Tadeusz and Boris-Möller, Fredrik}}, issn = {{0023-7205}}, language = {{swe}}, number = {{18}}, pages = {{2172--2175}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{Hög tid att pröva hypotermi i behandlingen av slaganfall}}, url = {{http://ltarkiv.lakartidningen.se/artNo22894}}, volume = {{98}}, year = {{2001}}, }