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Luteolin, a Potent Anticancer Compound : From Chemistry to Cellular Interactions and Synergetic Perspectives

Singh Tuli, Hardeep ; Rath, Prangya ; Chauhan, Abhishek ; Sak, Katrin ; Aggarwal, Diwakar ; Choudhary, Renuka ; Sharma, Ujjawal ; Vashishth, Kanupriya ; Sharma, Sheetu and Kumar, Manoj , et al. (2022) In Cancers 14(21).
Abstract

Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular processes such as apoptosis, cell-cycle progression, angiogenesis and migration. Mechanistically, luteolin causes cell death by downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2, and Bcl-xL, while upregulating BAX, caspase-3, and p21. It has also been reported to inhibit STAT3 signaling by the suppression of STAT3 activation and... (More)

Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular processes such as apoptosis, cell-cycle progression, angiogenesis and migration. Mechanistically, luteolin causes cell death by downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2, and Bcl-xL, while upregulating BAX, caspase-3, and p21. It has also been reported to inhibit STAT3 signaling by the suppression of STAT3 activation and enhanced STAT3 protein degradation in various cancer cells. Therefore, extensive studies on the anticancer properties of luteolin reveal its promising role in chemoprevention. The present review describes all the possible cellular interactions of luteolin in cancer, along with its synergistic mode of action and nanodelivery insight.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anti-inflammation, anti-metastasis, apoptosis and cell cycle, luteolin, synergistic action
in
Cancers
volume
14
issue
21
article number
5373
publisher
MDPI AG
external identifiers
  • pmid:36358791
  • scopus:85141719063
ISSN
2072-6694
DOI
10.3390/cancers14215373
language
English
LU publication?
yes
id
e5dc4626-bbca-48ee-a10e-d2b5b666d43f
date added to LUP
2022-11-30 09:44:59
date last changed
2024-06-25 21:39:29
@article{e5dc4626-bbca-48ee-a10e-d2b5b666d43f,
  abstract     = {{<p>Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular processes such as apoptosis, cell-cycle progression, angiogenesis and migration. Mechanistically, luteolin causes cell death by downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2, and Bcl-xL, while upregulating BAX, caspase-3, and p21. It has also been reported to inhibit STAT3 signaling by the suppression of STAT3 activation and enhanced STAT3 protein degradation in various cancer cells. Therefore, extensive studies on the anticancer properties of luteolin reveal its promising role in chemoprevention. The present review describes all the possible cellular interactions of luteolin in cancer, along with its synergistic mode of action and nanodelivery insight.</p>}},
  author       = {{Singh Tuli, Hardeep and Rath, Prangya and Chauhan, Abhishek and Sak, Katrin and Aggarwal, Diwakar and Choudhary, Renuka and Sharma, Ujjawal and Vashishth, Kanupriya and Sharma, Sheetu and Kumar, Manoj and Yadav, Vikas and Singh, Tejveer and Yerer, Mukerrem Betul and Haque, Shafiul}},
  issn         = {{2072-6694}},
  keywords     = {{anti-inflammation; anti-metastasis; apoptosis and cell cycle; luteolin; synergistic action}},
  language     = {{eng}},
  number       = {{21}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Luteolin, a Potent Anticancer Compound : From Chemistry to Cellular Interactions and Synergetic Perspectives}},
  url          = {{http://dx.doi.org/10.3390/cancers14215373}},
  doi          = {{10.3390/cancers14215373}},
  volume       = {{14}},
  year         = {{2022}},
}