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Reoperation for malignant astrocytomas : personal experience and a review of the literature

Strömblad, Lars-Göran LU ; Anderson, Harald LU ; Malmström, Per LU and Salford, Leif G. LU (1993) In British Journal of Neurosurgery 7(6). p.623-633
Abstract

All patients in a randomized study comparing chemotherapy with chemotherapy plus radiotherapy for patients with astrocytomas grade 3 and 4, were considered for reoperation when tumour progression was established. Fifty-eight patients were reoperated and 85 were not. Different prognostic factors, such as age, sex, Karnofsky performance status and reoperation were evaluated univariately and simultaneously in a multivariate model. The Karnofsky index and age were found to be independent prognostic factors, while re-operation could not be demonstrated to prolong life when controlled for age and the Karnofsky index. We review the literature on re-operation of malignant astrocytomas.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Analysis of Variance, Brain Neoplasms/drug therapy, Combined Modality Therapy, Female, Glioblastoma/drug therapy, Humans, Karnofsky Performance Status, Male, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models, Reoperation, Survival Rate
in
British Journal of Neurosurgery
volume
7
issue
6
pages
623 - 633
publisher
Taylor & Francis
external identifiers
  • scopus:0027762074
  • pmid:8161424
ISSN
0268-8697
DOI
10.3109/02688699308995091
language
English
LU publication?
no
id
e68bf08f-9bcc-4d21-87ec-7200ba985f8d
date added to LUP
2022-03-01 08:58:17
date last changed
2024-01-04 23:10:39
@article{e68bf08f-9bcc-4d21-87ec-7200ba985f8d,
  abstract     = {{<p>All patients in a randomized study comparing chemotherapy with chemotherapy plus radiotherapy for patients with astrocytomas grade 3 and 4, were considered for reoperation when tumour progression was established. Fifty-eight patients were reoperated and 85 were not. Different prognostic factors, such as age, sex, Karnofsky performance status and reoperation were evaluated univariately and simultaneously in a multivariate model. The Karnofsky index and age were found to be independent prognostic factors, while re-operation could not be demonstrated to prolong life when controlled for age and the Karnofsky index. We review the literature on re-operation of malignant astrocytomas.</p>}},
  author       = {{Strömblad, Lars-Göran and Anderson, Harald and Malmström, Per and Salford, Leif G.}},
  issn         = {{0268-8697}},
  keywords     = {{Analysis of Variance; Brain Neoplasms/drug therapy; Combined Modality Therapy; Female; Glioblastoma/drug therapy; Humans; Karnofsky Performance Status; Male; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Reoperation; Survival Rate}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{623--633}},
  publisher    = {{Taylor & Francis}},
  series       = {{British Journal of Neurosurgery}},
  title        = {{Reoperation for malignant astrocytomas : personal experience and a review of the literature}},
  url          = {{http://dx.doi.org/10.3109/02688699308995091}},
  doi          = {{10.3109/02688699308995091}},
  volume       = {{7}},
  year         = {{1993}},
}