Reoperation for malignant astrocytomas : personal experience and a review of the literature
(1993) In British Journal of Neurosurgery 7(6). p.623-633- Abstract
All patients in a randomized study comparing chemotherapy with chemotherapy plus radiotherapy for patients with astrocytomas grade 3 and 4, were considered for reoperation when tumour progression was established. Fifty-eight patients were reoperated and 85 were not. Different prognostic factors, such as age, sex, Karnofsky performance status and reoperation were evaluated univariately and simultaneously in a multivariate model. The Karnofsky index and age were found to be independent prognostic factors, while re-operation could not be demonstrated to prolong life when controlled for age and the Karnofsky index. We review the literature on re-operation of malignant astrocytomas.
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https://lup.lub.lu.se/record/e68bf08f-9bcc-4d21-87ec-7200ba985f8d
- author
- Strömblad, Lars-Göran LU ; Anderson, Harald LU ; Malmström, Per LU and Salford, Leif G. LU
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- keywords
- Analysis of Variance, Brain Neoplasms/drug therapy, Combined Modality Therapy, Female, Glioblastoma/drug therapy, Humans, Karnofsky Performance Status, Male, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models, Reoperation, Survival Rate
- in
- British Journal of Neurosurgery
- volume
- 7
- issue
- 6
- pages
- 623 - 633
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0027762074
- pmid:8161424
- ISSN
- 0268-8697
- DOI
- 10.3109/02688699308995091
- language
- English
- LU publication?
- no
- id
- e68bf08f-9bcc-4d21-87ec-7200ba985f8d
- date added to LUP
- 2022-03-01 08:58:17
- date last changed
- 2024-01-04 23:10:39
@article{e68bf08f-9bcc-4d21-87ec-7200ba985f8d, abstract = {{<p>All patients in a randomized study comparing chemotherapy with chemotherapy plus radiotherapy for patients with astrocytomas grade 3 and 4, were considered for reoperation when tumour progression was established. Fifty-eight patients were reoperated and 85 were not. Different prognostic factors, such as age, sex, Karnofsky performance status and reoperation were evaluated univariately and simultaneously in a multivariate model. The Karnofsky index and age were found to be independent prognostic factors, while re-operation could not be demonstrated to prolong life when controlled for age and the Karnofsky index. We review the literature on re-operation of malignant astrocytomas.</p>}}, author = {{Strömblad, Lars-Göran and Anderson, Harald and Malmström, Per and Salford, Leif G.}}, issn = {{0268-8697}}, keywords = {{Analysis of Variance; Brain Neoplasms/drug therapy; Combined Modality Therapy; Female; Glioblastoma/drug therapy; Humans; Karnofsky Performance Status; Male; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Reoperation; Survival Rate}}, language = {{eng}}, number = {{6}}, pages = {{623--633}}, publisher = {{Taylor & Francis}}, series = {{British Journal of Neurosurgery}}, title = {{Reoperation for malignant astrocytomas : personal experience and a review of the literature}}, url = {{http://dx.doi.org/10.3109/02688699308995091}}, doi = {{10.3109/02688699308995091}}, volume = {{7}}, year = {{1993}}, }