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QTL explaining variation in production traits and udder health in the Danish Holstein population

Thomsen, Hauke LU ; Thomasen, Jørn R.; Guldbrandtsen, Bernt and Lund, Mogens S. (2011) In Archiv fur Tierzucht 54(4). p.348-359
Abstract

The main objective was to locate QTL and estimate the proportion of total genetic variance attributable to quantitative trait loci (QTL) for production index traits and the udder health index identified on six Bos taurus autosomes in the Danish Holstein dairy cattle population. Data were obtained from a granddaughter design of 20 sire families with a total of 1 869 progeny tested sons. The number of sons per grandsire ranged from 20 to 284, with an average family size of 93.5. Indexes of the estimated breeding values were obtained for the milk production traits and for the udder health index from the Danish Agricultural Advisory Service database. A random-QTL model was applied to incorporate marker information into parameter estimation... (More)

The main objective was to locate QTL and estimate the proportion of total genetic variance attributable to quantitative trait loci (QTL) for production index traits and the udder health index identified on six Bos taurus autosomes in the Danish Holstein dairy cattle population. Data were obtained from a granddaughter design of 20 sire families with a total of 1 869 progeny tested sons. The number of sons per grandsire ranged from 20 to 284, with an average family size of 93.5. Indexes of the estimated breeding values were obtained for the milk production traits and for the udder health index from the Danish Agricultural Advisory Service database. A random-QTL model was applied to incorporate marker information into parameter estimation for each single QTL. The procedure allowed us to detect new QTL on BTA3, BTA16 and BTA28 and to estimate the proportion of total genetic variance attributed to different QTL on a total of six Bos taurus autosomes for the udder health index and yield index traits in the Danish Holstein population. Variance estimates vary between 2 to 58 % of the total variance for different QTL and seem to explain a substantial part of the variance at certain positions of the cattle genome. The results are discussed against the background of the failure of marker-assisted selection (MAS) and the recent availability of large panels of single nucleotide polymorphisms (SNPs) that have improved the search for mutations underlying variation in complex traits resulting in modern genomic selection.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Marker assisted selection, QTL, Variance component
in
Archiv fur Tierzucht
volume
54
issue
4
pages
12 pages
publisher
Forschungsinstitut fuer die Biologie Landwirtschaftlicher Nutztiere
external identifiers
  • scopus:80054967906
ISSN
0003-9438
language
English
LU publication?
no
id
e6945762-a831-4530-b006-24b06fc7b4b0
alternative location
http://www.archanimbreed.com/content/2011/abs11_04.html#A3
date added to LUP
2017-10-26 09:21:54
date last changed
2017-10-30 12:54:29
@article{e6945762-a831-4530-b006-24b06fc7b4b0,
  abstract     = {<p>The main objective was to locate QTL and estimate the proportion of total genetic variance attributable to quantitative trait loci (QTL) for production index traits and the udder health index identified on six Bos taurus autosomes in the Danish Holstein dairy cattle population. Data were obtained from a granddaughter design of 20 sire families with a total of 1 869 progeny tested sons. The number of sons per grandsire ranged from 20 to 284, with an average family size of 93.5. Indexes of the estimated breeding values were obtained for the milk production traits and for the udder health index from the Danish Agricultural Advisory Service database. A random-QTL model was applied to incorporate marker information into parameter estimation for each single QTL. The procedure allowed us to detect new QTL on BTA3, BTA16 and BTA28 and to estimate the proportion of total genetic variance attributed to different QTL on a total of six Bos taurus autosomes for the udder health index and yield index traits in the Danish Holstein population. Variance estimates vary between 2 to 58 % of the total variance for different QTL and seem to explain a substantial part of the variance at certain positions of the cattle genome. The results are discussed against the background of the failure of marker-assisted selection (MAS) and the recent availability of large panels of single nucleotide polymorphisms (SNPs) that have improved the search for mutations underlying variation in complex traits resulting in modern genomic selection.</p>},
  author       = {Thomsen, Hauke and Thomasen, Jørn R. and Guldbrandtsen, Bernt and Lund, Mogens S.},
  issn         = {0003-9438},
  keyword      = {Marker assisted selection,QTL,Variance component},
  language     = {eng},
  number       = {4},
  pages        = {348--359},
  publisher    = {Forschungsinstitut fuer die Biologie Landwirtschaftlicher Nutztiere},
  series       = {Archiv fur Tierzucht},
  title        = {QTL explaining variation in production traits and udder health in the Danish Holstein population},
  volume       = {54},
  year         = {2011},
}