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Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

de Maré, Sofia W. LU ; Venskutonytė, Raminta LU ; Eltschkner, Sandra LU ; de Groot, Bert L. and Lindkvist-Petersson, Karin LU (2020) In Structure 28(2). p.3-222
Abstract

AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adipocyte, AQP7, aquaglyceroporin, aquaporin 7, atomistic MD simulations, glycerol channel, water, X-ray structure
in
Structure
volume
28
issue
2
pages
3 - 222
publisher
Cell Press
external identifiers
  • scopus:85078470700
  • pmid:31831212
ISSN
0969-2126
DOI
10.1016/j.str.2019.11.011
language
English
LU publication?
yes
id
e6a6d9e1-70ef-4dd3-b22e-05090fe0e451
date added to LUP
2020-02-04 15:10:32
date last changed
2021-01-19 04:31:33
@article{e6a6d9e1-70ef-4dd3-b22e-05090fe0e451,
  abstract     = {<p>AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.</p>},
  author       = {de Maré, Sofia W. and Venskutonytė, Raminta and Eltschkner, Sandra and de Groot, Bert L. and Lindkvist-Petersson, Karin},
  issn         = {0969-2126},
  language     = {eng},
  month        = {02},
  number       = {2},
  pages        = {3--222},
  publisher    = {Cell Press},
  series       = {Structure},
  title        = {Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7},
  url          = {http://dx.doi.org/10.1016/j.str.2019.11.011},
  doi          = {10.1016/j.str.2019.11.011},
  volume       = {28},
  year         = {2020},
}