Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

de Maré, Sofia W. LU ; Venskutonytė, Raminta LU ; Eltschkner, Sandra LU ; de Groot, Bert L. and Lindkvist-Petersson, Karin LU (2020) In Structure 28(2). p.3-222
Abstract

AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.

Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adipocyte, AQP7, aquaglyceroporin, aquaporin 7, atomistic MD simulations, glycerol channel, water, X-ray structure
in
Structure
volume
28
issue
2
pages
3 - 222
publisher
Cell Press
external identifiers
  • scopus:85078470700
  • pmid:31831212
ISSN
0969-2126
DOI
10.1016/j.str.2019.11.011
language
English
LU publication?
yes
id
e6a6d9e1-70ef-4dd3-b22e-05090fe0e451
date added to LUP
2020-02-04 15:10:32
date last changed
2024-06-13 10:49:17
@article{e6a6d9e1-70ef-4dd3-b22e-05090fe0e451,
  abstract     = {{<p>AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.</p>}},
  author       = {{de Maré, Sofia W. and Venskutonytė, Raminta and Eltschkner, Sandra and de Groot, Bert L. and Lindkvist-Petersson, Karin}},
  issn         = {{0969-2126}},
  keywords     = {{adipocyte; AQP7; aquaglyceroporin; aquaporin 7; atomistic MD simulations; glycerol channel; water; X-ray structure}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  pages        = {{3--222}},
  publisher    = {{Cell Press}},
  series       = {{Structure}},
  title        = {{Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7}},
  url          = {{http://dx.doi.org/10.1016/j.str.2019.11.011}},
  doi          = {{10.1016/j.str.2019.11.011}},
  volume       = {{28}},
  year         = {{2020}},
}