Research updates in cystic fibrosis related diabetes : Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research
(2026) In Journal of Cystic Fibrosis 25(3). p.393-405- Abstract
In 2024–2025, the Cystic Fibrosis Foundation (US) and Cystic Fibrosis Trust (UK) hosted an International CFRD Consortium round-table webinar series for basic science, translational, and clinical researchers with the goal of sharpening mechanistic understanding of CFRD pathogenesis and prioritizing therapeutic development. This review summarizes the research priorities identified in the International CFRD Consortium, including (i) further investigation into the role of pancreatic fibrosis, vascular abnormalities, and α-cell dysfunction in the development of CFRD; (ii) the creation and refinement of novel animal and human cell- and tissue-based models to understand the complex interplay of exocrine and endocrine cells in the CF pancreas;... (More)
In 2024–2025, the Cystic Fibrosis Foundation (US) and Cystic Fibrosis Trust (UK) hosted an International CFRD Consortium round-table webinar series for basic science, translational, and clinical researchers with the goal of sharpening mechanistic understanding of CFRD pathogenesis and prioritizing therapeutic development. This review summarizes the research priorities identified in the International CFRD Consortium, including (i) further investigation into the role of pancreatic fibrosis, vascular abnormalities, and α-cell dysfunction in the development of CFRD; (ii) the creation and refinement of novel animal and human cell- and tissue-based models to understand the complex interplay of exocrine and endocrine cells in the CF pancreas; (iii) development and validation of circulating and imaging biomarkers, together with dynamic glucose testing to explore β-cell function and kinetics in people with CF across the dysglycemia spectrum; and (iv) prospective clinical studies to guide CFRD treatment options and investigate the changing landscape of aging, increasing prevalence of obesity and diabetes and their complications in the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulators. Collectively, these priorities aim to accelerate transition from mechanism to intervention and expand evidence-based care for people with CF at risk of, or living with, CFRD.
(Less)
- author
- Putman, Melissa S.
; Hull-Meichle, Rebecca L.
; Waters, Shafagh A.
; Tuggle, Katherine
; Sommer, Paula
; Conway, Rebecca
; Borthwick, Lee A.
; Knudsen, Jakob G.
; Dean, E. Danielle
; Stanley, Sarah A.
; Sun, Xingshen
; Engelhardt, John F.
; Leir, Shih Hsing
; Eliasson, Lena
LU
; Nielsen, Bibi Uhre
; Stefanovski, Darko
; Brennan, Amanda
; Boughton, Charlotte K.
; Kelly, Andrea
; Moheet, Amir
and Shaw, James A.M.
(Less) - organization
- publishing date
- 2026-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animal model, Cystic fibrosis, Cystic fibrosis related diabetes, Islet, Pancreas
- in
- Journal of Cystic Fibrosis
- volume
- 25
- issue
- 3
- pages
- 13 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:41936497
- scopus:105035020248
- ISSN
- 1569-1993
- DOI
- 10.1016/j.jcf.2026.03.021
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2026 European Cystic Fibrosis Society.
- id
- e6b770bc-6f2f-4739-b165-fb4f3e3a45d9
- date added to LUP
- 2026-06-22 10:52:41
- date last changed
- 2026-09-15 23:10:46
@article{e6b770bc-6f2f-4739-b165-fb4f3e3a45d9,
abstract = {{<p>In 2024–2025, the Cystic Fibrosis Foundation (US) and Cystic Fibrosis Trust (UK) hosted an International CFRD Consortium round-table webinar series for basic science, translational, and clinical researchers with the goal of sharpening mechanistic understanding of CFRD pathogenesis and prioritizing therapeutic development. This review summarizes the research priorities identified in the International CFRD Consortium, including (i) further investigation into the role of pancreatic fibrosis, vascular abnormalities, and α-cell dysfunction in the development of CFRD; (ii) the creation and refinement of novel animal and human cell- and tissue-based models to understand the complex interplay of exocrine and endocrine cells in the CF pancreas; (iii) development and validation of circulating and imaging biomarkers, together with dynamic glucose testing to explore β-cell function and kinetics in people with CF across the dysglycemia spectrum; and (iv) prospective clinical studies to guide CFRD treatment options and investigate the changing landscape of aging, increasing prevalence of obesity and diabetes and their complications in the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulators. Collectively, these priorities aim to accelerate transition from mechanism to intervention and expand evidence-based care for people with CF at risk of, or living with, CFRD.</p>}},
author = {{Putman, Melissa S. and Hull-Meichle, Rebecca L. and Waters, Shafagh A. and Tuggle, Katherine and Sommer, Paula and Conway, Rebecca and Borthwick, Lee A. and Knudsen, Jakob G. and Dean, E. Danielle and Stanley, Sarah A. and Sun, Xingshen and Engelhardt, John F. and Leir, Shih Hsing and Eliasson, Lena and Nielsen, Bibi Uhre and Stefanovski, Darko and Brennan, Amanda and Boughton, Charlotte K. and Kelly, Andrea and Moheet, Amir and Shaw, James A.M.}},
issn = {{1569-1993}},
keywords = {{Animal model; Cystic fibrosis; Cystic fibrosis related diabetes; Islet; Pancreas}},
language = {{eng}},
number = {{3}},
pages = {{393--405}},
publisher = {{Elsevier}},
series = {{Journal of Cystic Fibrosis}},
title = {{Research updates in cystic fibrosis related diabetes : Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research}},
url = {{http://dx.doi.org/10.1016/j.jcf.2026.03.021}},
doi = {{10.1016/j.jcf.2026.03.021}},
volume = {{25}},
year = {{2026}},
}