Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk
(2013) In Diabetes Care 36(4). p.1012-1019- Abstract
- OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive... (More)
- OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013 (Less)
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https://lup.lub.lu.se/record/3765004
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 36
- issue
- 4
- pages
- 1012 - 1019
- publisher
- American Diabetes Association
- external identifiers
-
- wos:000316462400053
- scopus:84875421600
- ISSN
- 1935-5548
- DOI
- 10.2337/dc12-1020
- language
- English
- LU publication?
- yes
- id
- e6bb62e5-8580-4654-9ba7-e127c1bc16cf (old id 3765004)
- date added to LUP
- 2016-04-01 13:45:21
- date last changed
- 2024-05-09 11:43:26
@article{e6bb62e5-8580-4654-9ba7-e127c1bc16cf,
abstract = {{OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013}},
author = {{Brand, Judith S. and van der Schouw, Yvonne T. and Onland-Moret, N. Charlotte and Sharp, Stephen J. and Ong, Ken K. and Khaw, Kay-Tee and Ardanaz, Eva and Amiano, Pilar and Boeing, Heiner and Chirlaque, Maria-Dolores and Clavel-Chapelon, Francoise and Crowe, Francesca L. and de Lauzon-Guillain, Blandine and Duell, Eric J. and Fagherazzi, Guy and Franks, Paul and Grioni, Sara and Groop, Leif and Kaaks, Rudolf and Key, Timothy J. and Nilsson, Peter and Overvad, Kim and Palli, Domenico and Panico, Salvatore and Quiros, J. Ramon and Rolandsson, Olov and Sacerdote, Carlotta and Sanchez, Maria-Jose and Slimani, Nadia and Teucher, Birgit and Tjonneland, Anne and Tumino, Rosario and van der A, Daphne L. and Feskens, Edith J. M. and Langenberg, Claudia and Forouhi, Nita G. and Riboli, Elio and Wareham, Nicholas J.}},
issn = {{1935-5548}},
language = {{eng}},
number = {{4}},
pages = {{1012--1019}},
publisher = {{American Diabetes Association}},
series = {{Diabetes Care}},
title = {{Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk}},
url = {{http://dx.doi.org/10.2337/dc12-1020}},
doi = {{10.2337/dc12-1020}},
volume = {{36}},
year = {{2013}},
}