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Antihypertensive treatment in critical limb Ischaemia

Gottsäter, Anders LU and Nilsson, Peter M. LU (2016) In Arterial Hypertension 20(4). p.195-197
Abstract

Peripheral artery disease (PAD) is defined as atherosclerotic arterial occlusive disease of the lower extremities, manifesting as intermittent claudication (IC, pain induced by walking) or critical limb ischaemia (CLI, rest pain or ulcerations). PAD guidelines recommend strict control of cardiovascular risk factors, and European guidelines on hypertension recommend a blood pressure (BP) target < 140/90 mm Hg also in PAD patients. As the pressure in the affected extremity might be of relevance for the prognosis concerning limb salvage in CLI, the traditional approach was to avoid beta-blockers and allow a slightly higher BP in CLI. Both theoretical considerations and observational data support aggressive BP lowering also in CLI;... (More)

Peripheral artery disease (PAD) is defined as atherosclerotic arterial occlusive disease of the lower extremities, manifesting as intermittent claudication (IC, pain induced by walking) or critical limb ischaemia (CLI, rest pain or ulcerations). PAD guidelines recommend strict control of cardiovascular risk factors, and European guidelines on hypertension recommend a blood pressure (BP) target < 140/90 mm Hg also in PAD patients. As the pressure in the affected extremity might be of relevance for the prognosis concerning limb salvage in CLI, the traditional approach was to avoid beta-blockers and allow a slightly higher BP in CLI. Both theoretical considerations and observational data support aggressive BP lowering also in CLI; however, in the absence of randomized studies on BP lowering in this setting it cannot be definitely established that current recommendations on BP lowering apply also in CLI.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood pressure, Critical limb ischaemia, Peripheral artery disease
in
Arterial Hypertension
volume
20
issue
4
pages
3 pages
publisher
Via Medica
external identifiers
  • scopus:85007495785
  • scopus:85016061513
ISSN
2449-6162
DOI
10.5603/AH.2016.0020
language
English
LU publication?
yes
id
e6e8d93a-76f9-4ad8-ac35-a488c32b0fd1
date added to LUP
2017-01-13 07:23:13
date last changed
2017-04-19 13:10:27
@article{e6e8d93a-76f9-4ad8-ac35-a488c32b0fd1,
  abstract     = {<p>Peripheral artery disease (PAD) is defined as atherosclerotic arterial occlusive disease of the lower extremities, manifesting as intermittent claudication (IC, pain induced by walking) or critical limb ischaemia (CLI, rest pain or ulcerations). PAD guidelines recommend strict control of cardiovascular risk factors, and European guidelines on hypertension recommend a blood pressure (BP) target &lt; 140/90 mm Hg also in PAD patients. As the pressure in the affected extremity might be of relevance for the prognosis concerning limb salvage in CLI, the traditional approach was to avoid beta-blockers and allow a slightly higher BP in CLI. Both theoretical considerations and observational data support aggressive BP lowering also in CLI; however, in the absence of randomized studies on BP lowering in this setting it cannot be definitely established that current recommendations on BP lowering apply also in CLI.</p>},
  author       = {Gottsäter, Anders and Nilsson, Peter M.},
  issn         = {2449-6162},
  keyword      = {Blood pressure,Critical limb ischaemia,Peripheral artery disease},
  language     = {eng},
  month        = {12},
  number       = {4},
  pages        = {195--197},
  publisher    = {Via Medica},
  series       = {Arterial Hypertension},
  title        = {Antihypertensive treatment in critical limb Ischaemia},
  url          = {http://dx.doi.org/10.5603/AH.2016.0020},
  volume       = {20},
  year         = {2016},
}