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Dilated cardiomyopathy evaluation with Imagenomics : combining multimodal cardiovascular imaging and genetics

Galanti, Kristian ; Dabbagh, Ghaith Sharaf ; Ricci, Fabrizio LU ; Gallina, Sabina ; Giansante, Roberta ; Jacob, Ron ; Obeng-Gyimah, Edmond ; Cooper, Leslie T. ; Prasad, Sanjay K. and Birnie, David H. , et al. (2025) In ESC Heart Failure 12(4). p.2669-2690
Abstract

Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by the presence of left ventricular dilatation and systolic dysfunction unexplained by abnormal loading conditions or coronary artery disease. However, a broad range of phenotypic manifestations, encompassing isolated scar, DCM with preserved ejection fraction, and overt DCM, should be regarded as a diagnostic classification representing a broad spectrum of underlying aetiologies, including both inherited and acquired heart muscle disorders. A multimodal non-invasive imaging approach is essential for accurate morpho-functional assessment of cardiac chambers and is key to establish the cardiac phenotype and to rule out an underlying ischaemic aetiology. Furthermore,... (More)

Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by the presence of left ventricular dilatation and systolic dysfunction unexplained by abnormal loading conditions or coronary artery disease. However, a broad range of phenotypic manifestations, encompassing isolated scar, DCM with preserved ejection fraction, and overt DCM, should be regarded as a diagnostic classification representing a broad spectrum of underlying aetiologies, including both inherited and acquired heart muscle disorders. A multimodal non-invasive imaging approach is essential for accurate morpho-functional assessment of cardiac chambers and is key to establish the cardiac phenotype and to rule out an underlying ischaemic aetiology. Furthermore, advanced imaging techniques enable deep cardiovascular phenotyping and non-invasive tissue characterization. The aim of this review is to propose a systematic approach to the diagnosis of DCM, emphasizing the importance of genetics and clinical findings for a precise and practical clinical approach. Also, we strive to qualify the role of cardiac imaging in the diagnosis of DCM, particularly on the relevance of novel techniques and clinical utility of actionable parameters to improve current diagnostic schemes and risk stratification algorithms. We further elaborate on the role of cardiac imaging to deliver optimal guidance to aetiology-based therapeutic approaches, verification of treatment response and disease progression monitoring.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DCM perspectives, Dilated cardiomyopathy, Genetics, Multimodal cardiovascular imaging, Personalized medicine
in
ESC Heart Failure
volume
12
issue
4
pages
22 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:105003461266
  • pmid:40275589
ISSN
2055-5822
DOI
10.1002/ehf2.15307
language
English
LU publication?
yes
id
e7818726-a41e-48c9-91b1-62a6d1d84e28
date added to LUP
2025-09-29 13:29:12
date last changed
2025-09-30 03:00:02
@article{e7818726-a41e-48c9-91b1-62a6d1d84e28,
  abstract     = {{<p>Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by the presence of left ventricular dilatation and systolic dysfunction unexplained by abnormal loading conditions or coronary artery disease. However, a broad range of phenotypic manifestations, encompassing isolated scar, DCM with preserved ejection fraction, and overt DCM, should be regarded as a diagnostic classification representing a broad spectrum of underlying aetiologies, including both inherited and acquired heart muscle disorders. A multimodal non-invasive imaging approach is essential for accurate morpho-functional assessment of cardiac chambers and is key to establish the cardiac phenotype and to rule out an underlying ischaemic aetiology. Furthermore, advanced imaging techniques enable deep cardiovascular phenotyping and non-invasive tissue characterization. The aim of this review is to propose a systematic approach to the diagnosis of DCM, emphasizing the importance of genetics and clinical findings for a precise and practical clinical approach. Also, we strive to qualify the role of cardiac imaging in the diagnosis of DCM, particularly on the relevance of novel techniques and clinical utility of actionable parameters to improve current diagnostic schemes and risk stratification algorithms. We further elaborate on the role of cardiac imaging to deliver optimal guidance to aetiology-based therapeutic approaches, verification of treatment response and disease progression monitoring.</p>}},
  author       = {{Galanti, Kristian and Dabbagh, Ghaith Sharaf and Ricci, Fabrizio and Gallina, Sabina and Giansante, Roberta and Jacob, Ron and Obeng-Gyimah, Edmond and Cooper, Leslie T. and Prasad, Sanjay K. and Birnie, David H. and Landstrom, Andrew P. and Mohammed, Selma F. and Mohiddin, Saidi and Khanji, Mohammed Y. and Chahal, Anwar A.}},
  issn         = {{2055-5822}},
  keywords     = {{DCM perspectives; Dilated cardiomyopathy; Genetics; Multimodal cardiovascular imaging; Personalized medicine}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{2669--2690}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{ESC Heart Failure}},
  title        = {{Dilated cardiomyopathy evaluation with Imagenomics : combining multimodal cardiovascular imaging and genetics}},
  url          = {{http://dx.doi.org/10.1002/ehf2.15307}},
  doi          = {{10.1002/ehf2.15307}},
  volume       = {{12}},
  year         = {{2025}},
}