Characteristics of the Offspring of Women with a History of Malignancy, Excluding Congenital Malformations
(2016) In Journal of Obstetrics and Gynaecology Canada 38(11). p.1037-1044- Abstract
Objective To study the characteristics (except congenital malformations) of offspring born to women with a history of malignancy. Methods Data were obtained by linkage between four different Swedish national health registers. We compared the offspring born between 1994 and 2011 of women with a history of malignancy with all other infants. Survival of the infants was followed up through 2013. Adjusting for confounders was performed using Mantel-Haenszel methodology. We identified 7315 infants born to women with a history of a malignancy diagnosed at least 1 year before delivery. The total number of deliveries in Sweden in these years was 1 746 870, with 1 780 112 infants being born. We assessed rates of intrauterine death, preterm birth,... (More)
Objective To study the characteristics (except congenital malformations) of offspring born to women with a history of malignancy. Methods Data were obtained by linkage between four different Swedish national health registers. We compared the offspring born between 1994 and 2011 of women with a history of malignancy with all other infants. Survival of the infants was followed up through 2013. Adjusting for confounders was performed using Mantel-Haenszel methodology. We identified 7315 infants born to women with a history of a malignancy diagnosed at least 1 year before delivery. The total number of deliveries in Sweden in these years was 1 746 870, with 1 780 112 infants being born. We assessed rates of intrauterine death, preterm birth, low birth weight, and the nature of intrauterine growth. We also examined neonatal diagnoses (asphyxia, chronic respiratory condition, intracranial hemorrhage, jaundice, hypoglycemia, CNS symptoms) and infant death. Results In women with a history of malignancy, we found no significantly increased risk for stillbirth or infant death. There were elevated rates of preterm birth (OR 1.50, 95% CI 1.37 to 1.64), very preterm birth (OR 1.89, 95% CI 1.54 to 2.32), and low birth weight (OR 1.50, 95% CI 1.34 to 1.68). There was a significantly increased risk of birth asphyxia, jaundice, hypoglycemia, and low Apgar score among infants born to women with a history of malignancy (OR 1.24, 95% CI 1.15 to 1.33), and this risk was maintained after excluding infants born after IVF. Conclusion We found an increased risk of preterm birth and low birth weight among infants of women with a history of malignancy, and as a result, found an increased risk of neonatal morbidity. No significant increase in risk of intrauterine or postnatal death was noted.
(Less)
- author
- Sabeti Rad, Zahra LU ; Friberg, Britt LU ; Henic, Emir LU ; Rylander, Lars LU ; Ståhl, Olof LU ; Källén, Bengt LU and Lingman, Göran LU
- organization
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Malignant disease, neonatal morbidity, offspring, preterm, stillbirth
- in
- Journal of Obstetrics and Gynaecology Canada
- volume
- 38
- issue
- 11
- pages
- 8 pages
- publisher
- Healthcare & Financial Pub.
- external identifiers
-
- pmid:27969558
- scopus:84994267542
- ISSN
- 1701-2163
- DOI
- 10.1016/j.jogc.2016.07.001
- language
- English
- LU publication?
- yes
- id
- e82720b0-f9b3-489a-b67a-a585249a6956
- date added to LUP
- 2016-12-05 10:12:38
- date last changed
- 2024-03-07 17:34:39
@article{e82720b0-f9b3-489a-b67a-a585249a6956, abstract = {{<p>Objective To study the characteristics (except congenital malformations) of offspring born to women with a history of malignancy. Methods Data were obtained by linkage between four different Swedish national health registers. We compared the offspring born between 1994 and 2011 of women with a history of malignancy with all other infants. Survival of the infants was followed up through 2013. Adjusting for confounders was performed using Mantel-Haenszel methodology. We identified 7315 infants born to women with a history of a malignancy diagnosed at least 1 year before delivery. The total number of deliveries in Sweden in these years was 1 746 870, with 1 780 112 infants being born. We assessed rates of intrauterine death, preterm birth, low birth weight, and the nature of intrauterine growth. We also examined neonatal diagnoses (asphyxia, chronic respiratory condition, intracranial hemorrhage, jaundice, hypoglycemia, CNS symptoms) and infant death. Results In women with a history of malignancy, we found no significantly increased risk for stillbirth or infant death. There were elevated rates of preterm birth (OR 1.50, 95% CI 1.37 to 1.64), very preterm birth (OR 1.89, 95% CI 1.54 to 2.32), and low birth weight (OR 1.50, 95% CI 1.34 to 1.68). There was a significantly increased risk of birth asphyxia, jaundice, hypoglycemia, and low Apgar score among infants born to women with a history of malignancy (OR 1.24, 95% CI 1.15 to 1.33), and this risk was maintained after excluding infants born after IVF. Conclusion We found an increased risk of preterm birth and low birth weight among infants of women with a history of malignancy, and as a result, found an increased risk of neonatal morbidity. No significant increase in risk of intrauterine or postnatal death was noted.</p>}}, author = {{Sabeti Rad, Zahra and Friberg, Britt and Henic, Emir and Rylander, Lars and Ståhl, Olof and Källén, Bengt and Lingman, Göran}}, issn = {{1701-2163}}, keywords = {{Malignant disease; neonatal morbidity; offspring; preterm; stillbirth}}, language = {{eng}}, month = {{11}}, number = {{11}}, pages = {{1037--1044}}, publisher = {{Healthcare & Financial Pub.}}, series = {{Journal of Obstetrics and Gynaecology Canada}}, title = {{Characteristics of the Offspring of Women with a History of Malignancy, Excluding Congenital Malformations}}, url = {{http://dx.doi.org/10.1016/j.jogc.2016.07.001}}, doi = {{10.1016/j.jogc.2016.07.001}}, volume = {{38}}, year = {{2016}}, }