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Characteristics of the Offspring of Women with a History of Malignancy, Excluding Congenital Malformations

Sabeti Rad, Zahra LU ; Friberg, Britt LU ; Henic, Emir LU ; Rylander, Lars LU ; Ståhl, Olof LU ; Källén, Bengt LU and Lingman, Göran LU (2016) In Journal of Obstetrics and Gynaecology Canada 38(11). p.1037-1044
Abstract

Objective To study the characteristics (except congenital malformations) of offspring born to women with a history of malignancy. Methods Data were obtained by linkage between four different Swedish national health registers. We compared the offspring born between 1994 and 2011 of women with a history of malignancy with all other infants. Survival of the infants was followed up through 2013. Adjusting for confounders was performed using Mantel-Haenszel methodology. We identified 7315 infants born to women with a history of a malignancy diagnosed at least 1 year before delivery. The total number of deliveries in Sweden in these years was 1 746 870, with 1 780 112 infants being born. We assessed rates of intrauterine death, preterm birth,... (More)

Objective To study the characteristics (except congenital malformations) of offspring born to women with a history of malignancy. Methods Data were obtained by linkage between four different Swedish national health registers. We compared the offspring born between 1994 and 2011 of women with a history of malignancy with all other infants. Survival of the infants was followed up through 2013. Adjusting for confounders was performed using Mantel-Haenszel methodology. We identified 7315 infants born to women with a history of a malignancy diagnosed at least 1 year before delivery. The total number of deliveries in Sweden in these years was 1 746 870, with 1 780 112 infants being born. We assessed rates of intrauterine death, preterm birth, low birth weight, and the nature of intrauterine growth. We also examined neonatal diagnoses (asphyxia, chronic respiratory condition, intracranial hemorrhage, jaundice, hypoglycemia, CNS symptoms) and infant death. Results In women with a history of malignancy, we found no significantly increased risk for stillbirth or infant death. There were elevated rates of preterm birth (OR 1.50, 95% CI 1.37 to 1.64), very preterm birth (OR 1.89, 95% CI 1.54 to 2.32), and low birth weight (OR 1.50, 95% CI 1.34 to 1.68). There was a significantly increased risk of birth asphyxia, jaundice, hypoglycemia, and low Apgar score among infants born to women with a history of malignancy (OR 1.24, 95% CI 1.15 to 1.33), and this risk was maintained after excluding infants born after IVF. Conclusion We found an increased risk of preterm birth and low birth weight among infants of women with a history of malignancy, and as a result, found an increased risk of neonatal morbidity. No significant increase in risk of intrauterine or postnatal death was noted.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Malignant disease, neonatal morbidity, offspring, preterm, stillbirth
in
Journal of Obstetrics and Gynaecology Canada
volume
38
issue
11
pages
8 pages
publisher
Healthcare & Financial Pub.
external identifiers
  • scopus:84994267542
ISSN
1701-2163
DOI
10.1016/j.jogc.2016.07.001
language
English
LU publication?
yes
id
e82720b0-f9b3-489a-b67a-a585249a6956
date added to LUP
2016-12-05 10:12:38
date last changed
2017-10-29 04:54:58
@article{e82720b0-f9b3-489a-b67a-a585249a6956,
  abstract     = {<p>Objective To study the characteristics (except congenital malformations) of offspring born to women with a history of malignancy. Methods Data were obtained by linkage between four different Swedish national health registers. We compared the offspring born between 1994 and 2011 of women with a history of malignancy with all other infants. Survival of the infants was followed up through 2013. Adjusting for confounders was performed using Mantel-Haenszel methodology. We identified 7315 infants born to women with a history of a malignancy diagnosed at least 1 year before delivery. The total number of deliveries in Sweden in these years was 1 746 870, with 1 780 112 infants being born. We assessed rates of intrauterine death, preterm birth, low birth weight, and the nature of intrauterine growth. We also examined neonatal diagnoses (asphyxia, chronic respiratory condition, intracranial hemorrhage, jaundice, hypoglycemia, CNS symptoms) and infant death. Results In women with a history of malignancy, we found no significantly increased risk for stillbirth or infant death. There were elevated rates of preterm birth (OR 1.50, 95% CI 1.37 to 1.64), very preterm birth (OR 1.89, 95% CI 1.54 to 2.32), and low birth weight (OR 1.50, 95% CI 1.34 to 1.68). There was a significantly increased risk of birth asphyxia, jaundice, hypoglycemia, and low Apgar score among infants born to women with a history of malignancy (OR 1.24, 95% CI 1.15 to 1.33), and this risk was maintained after excluding infants born after IVF. Conclusion We found an increased risk of preterm birth and low birth weight among infants of women with a history of malignancy, and as a result, found an increased risk of neonatal morbidity. No significant increase in risk of intrauterine or postnatal death was noted.</p>},
  author       = {Sabeti Rad, Zahra and Friberg, Britt and Henic, Emir and Rylander, Lars and Ståhl, Olof and Källén, Bengt and Lingman, Göran},
  issn         = {1701-2163},
  keyword      = {Malignant disease,neonatal morbidity,offspring,preterm,stillbirth},
  language     = {eng},
  month        = {11},
  number       = {11},
  pages        = {1037--1044},
  publisher    = {Healthcare & Financial Pub.},
  series       = {Journal of Obstetrics and Gynaecology Canada},
  title        = {Characteristics of the Offspring of Women with a History of Malignancy, Excluding Congenital Malformations},
  url          = {http://dx.doi.org/10.1016/j.jogc.2016.07.001},
  volume       = {38},
  year         = {2016},
}