Serum Levels of 2,2,4,4,5,5 -Hexachlorobiphenyl (CB-153) in Relation to Markers of Reproductive Function in Young Males from the General Swedish Population.

Richthoff, Jonas; Rylander, Lars; Jönsson, Bo A; Åkesson, Heléne; Hagmar, Lars; Nilsson-Ehle, Peter; Stridsberg, Mats; Giwercman, Aleksander

Serum Levels of 2,2,4,4,5,5 -Hexachlorobiphenyl (CB-153) in Relation to Markers of Reproductive Function in Young Males from the General Swedish Population.

Mark

Richthoff, Jonas ^LU ; Rylander, Lars ^LU

; Jönsson, Bo A ^LU ; Åkesson, Heléne ^LU ; Hagmar, Lars ; Nilsson-Ehle, Peter ^LU ; Stridsberg, Mats and Giwercman, Aleksander ^LU (2003) In Environmental Health Perspectives 111(4). p.409-413

Abstract: A time-related deterioration in male reproductive function caused by exposure to endocrine disrupters, including persistent organochlorines (POCs), has been hypothesized. In animal studies, POCs were found to have adverse effects on male reproductive function. However, little is known about the impact of POC exposure on reproductive parameters in men. In a study of 305 young Swedish men 18-21 years old from the general population, we correlated lipid-adjusted serum levels of 2,2´,4,4´,5,5´-hexachlorobiphenyl (CB-153)--an index substance for POC exposure--to markers of male reproductive function: testis size assessed by ultrasound, sperm concentration, total sperm count, sperm motility assessed manually and with a computer-aided sperm... (More); A time-related deterioration in male reproductive function caused by exposure to endocrine disrupters, including persistent organochlorines (POCs), has been hypothesized. In animal studies, POCs were found to have adverse effects on male reproductive function. However, little is known about the impact of POC exposure on reproductive parameters in men. In a study of 305 young Swedish men 18-21 years old from the general population, we correlated lipid-adjusted serum levels of 2,2´,4,4´,5,5´-hexachlorobiphenyl (CB-153)--an index substance for POC exposure--to markers of male reproductive function: testis size assessed by ultrasound, sperm concentration, total sperm count, sperm motility assessed manually and with a computer-aided sperm analyzer (CASA), and serum levels of follicle-stimulating hormone, inhibin B, testosterone, sexual hormone-binding globulin (SHBG), luteinizing hormone, and estradiol. We found weak but statistically significant, negative correlations between CB-153 levels and both the testosterone:SHBG ratio (r = -0.25, p < 0.001)--a measure of the biologically active free testosterone fraction--and CASA sperm motility (r = -0.13, p = 0.02). No statistically significant association with other seminal, hormonal, or clinical markers of male reproductive function was found. In previous studies of more highly POC-exposed groups of adult men, the correlation between POC exposure, including CB-153, and free testosterone levels was not statistically significant. The present study gives some tentative support for weak negative effects of CB-153 exposure on sperm motility and free testosterone levels in young men, but further semen studies on more highly exposed groups may give more firm conclusions on the hazard for male reproductive function from dietary POC exposure. Key words: dioxin, male reproduction, PCB, reproductive hormones, semen quality, sperm concentration, sperm motility. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/113569

author

Richthoff, Jonas ^LU ; Rylander, Lars ^LU

; Jönsson, Bo A ^LU ; Åkesson, Heléne ^LU ; Hagmar, Lars ; Nilsson-Ehle, Peter ^LU ; Stridsberg, Mats and Giwercman, Aleksander ^LU

organization

publishing date

2003

type

Contribution to journal

publication status

published

subject

Environmental Health and Occupational Health

in

Environmental Health Perspectives

volume

111

issue

4

pages

409 - 413

publisher

National Institute of Environmental Health Sciences

external identifiers

wos:000182144300023
pmid:12676591
scopus:0038076142

ISSN

1552-9924

DOI

10.1289/ehp.5767

language

English

LU publication?

yes

id

e891efd5-33fe-4969-a742-cbc794fb6d5d (old id 113569)

alternative location

http://www.ehponline.org/members/2003/5767/5767.html

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12676591&dopt=Abstract

date added to LUP

2016-04-01 15:39:15

date last changed

2022-02-05 02:21:50

@article{e891efd5-33fe-4969-a742-cbc794fb6d5d,
  abstract     = {{A time-related deterioration in male reproductive function caused by exposure to endocrine disrupters, including persistent organochlorines (POCs), has been hypothesized. In animal studies, POCs were found to have adverse effects on male reproductive function. However, little is known about the impact of POC exposure on reproductive parameters in men. In a study of 305 young Swedish men 18-21 years old from the general population, we correlated lipid-adjusted serum levels of 2,2´,4,4´,5,5´-hexachlorobiphenyl (CB-153)--an index substance for POC exposure--to markers of male reproductive function: testis size assessed by ultrasound, sperm concentration, total sperm count, sperm motility assessed manually and with a computer-aided sperm analyzer (CASA), and serum levels of follicle-stimulating hormone, inhibin B, testosterone, sexual hormone-binding globulin (SHBG), luteinizing hormone, and estradiol. We found weak but statistically significant, negative correlations between CB-153 levels and both the testosterone:SHBG ratio (r = -0.25, p &lt; 0.001)--a measure of the biologically active free testosterone fraction--and CASA sperm motility (r = -0.13, p = 0.02). No statistically significant association with other seminal, hormonal, or clinical markers of male reproductive function was found. In previous studies of more highly POC-exposed groups of adult men, the correlation between POC exposure, including CB-153, and free testosterone levels was not statistically significant. The present study gives some tentative support for weak negative effects of CB-153 exposure on sperm motility and free testosterone levels in young men, but further semen studies on more highly exposed groups may give more firm conclusions on the hazard for male reproductive function from dietary POC exposure. Key words: dioxin, male reproduction, PCB, reproductive hormones, semen quality, sperm concentration, sperm motility.}},
  author       = {{Richthoff, Jonas and Rylander, Lars and Jönsson, Bo A and Åkesson, Heléne and Hagmar, Lars and Nilsson-Ehle, Peter and Stridsberg, Mats and Giwercman, Aleksander}},
  issn         = {{1552-9924}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{409--413}},
  publisher    = {{National Institute of Environmental Health Sciences}},
  series       = {{Environmental Health Perspectives}},
  title        = {{Serum Levels of 2,2,4,4,5,5 -Hexachlorobiphenyl (CB-153) in Relation to Markers of Reproductive Function in Young Males from the General Swedish Population.}},
  url          = {{https://lup.lub.lu.se/search/files/4441850/623750.pdf}},
  doi          = {{10.1289/ehp.5767}},
  volume       = {{111}},
  year         = {{2003}},
}

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Serum Levels of 2,2,4,4,5,5 -Hexachlorobiphenyl (CB-153) in Relation to Markers of Reproductive Function in Young Males from the General Swedish Population.