HAMLET; a novel tool to identify apoptotic pathways in tumor cells.
Düringer, Caroline LU ; Hallgren, Oskar LU ; Gustafsson, Lotta LU
; Pettersson, Jenny
LU
; Mossberg, Anki
LU
; Manolov, Taras
LU
and Svanborg, Catharina
LU
(2005)
p.223-245
- Abstract
- Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell death programs in tumor cells but not in healthy differentiated cells. We use HAMLET as a tool to identify apoptosis and apoptosis-like cell death mechanisms in tumor cells and to understand if these mechanisms differ between tumor and healthy cells. HAMLET interacts with the cell surface, translocates into the cytoplasm and accumulates in cell... (More)
- Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell death programs in tumor cells but not in healthy differentiated cells. We use HAMLET as a tool to identify apoptosis and apoptosis-like cell death mechanisms in tumor cells and to understand if these mechanisms differ between tumor and healthy cells. HAMLET interacts with the cell surface, translocates into the cytoplasm and accumulates in cell nuclei, where it disrupts the chromatin. Recent in vivo studies have shown that HAMLET maintains the tumoricidal activity in glioblastoma, papilloma and bladder cancer models, with no significant side effects. The results suggest that HAMLET should be explored as a new therapeutic agent with selectivity for the tumor and with little toxicity for adjacent healthy tissue. Such therapies are a much-needed complement to conventional treatments, to reduce the side effects and improve the selectivity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1133837
- author
- Düringer, Caroline
LU
; Hallgren, Oskar
LU
; Gustafsson, Lotta
LU
; Pettersson, Jenny
LU
; Mossberg, Anki
LU
; Manolov, Taras
LU
and Svanborg, Catharina
LU
- organization
- publishing date
- 2005
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- HAMLET, lactalbumin, cancer, apoptosis, apoptosis-like, programmed cell death, alpha- histone, p53, bcl-2, caspase, glioblastoma, HPV
- host publication
- Application of apoptosis to cancer treatment.
- editor
- Mels, Sluyser
- pages
- 223 - 245
- publisher
- Springer
- external identifiers
-
- scopus:84900583644
- ISBN
- 978-1-4020-3303-2
- DOI
- 10.1007/1-4020-3302-8_10
- language
- English
- LU publication?
- yes
- id
- e8a5adeb-3e7e-435a-a85d-59eace874ee6 (old id 1133837)
- date added to LUP
- 2016-04-04 11:21:09
- date last changed
- 2022-01-29 21:41:52
@inbook{e8a5adeb-3e7e-435a-a85d-59eace874ee6,
abstract = {{Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell death programs in tumor cells but not in healthy differentiated cells. We use HAMLET as a tool to identify apoptosis and apoptosis-like cell death mechanisms in tumor cells and to understand if these mechanisms differ between tumor and healthy cells. HAMLET interacts with the cell surface, translocates into the cytoplasm and accumulates in cell nuclei, where it disrupts the chromatin. Recent in vivo studies have shown that HAMLET maintains the tumoricidal activity in glioblastoma, papilloma and bladder cancer models, with no significant side effects. The results suggest that HAMLET should be explored as a new therapeutic agent with selectivity for the tumor and with little toxicity for adjacent healthy tissue. Such therapies are a much-needed complement to conventional treatments, to reduce the side effects and improve the selectivity.}},
author = {{Düringer, Caroline and Hallgren, Oskar and Gustafsson, Lotta and Pettersson, Jenny and Mossberg, Anki and Manolov, Taras and Svanborg, Catharina}},
booktitle = {{Application of apoptosis to cancer treatment.}},
editor = {{Mels, Sluyser}},
isbn = {{978-1-4020-3303-2}},
keywords = {{HAMLET; lactalbumin; cancer; apoptosis; apoptosis-like; programmed cell death; alpha- histone; p53; bcl-2; caspase; glioblastoma; HPV}},
language = {{eng}},
pages = {{223--245}},
publisher = {{Springer}},
title = {{HAMLET; a novel tool to identify apoptotic pathways in tumor cells.}},
url = {{http://dx.doi.org/10.1007/1-4020-3302-8_10}},
doi = {{10.1007/1-4020-3302-8_10}},
year = {{2005}},
}