Establishing aluminium contact allergy.
(2012) In Contact Dermatitis 67(3). p.162-170- Abstract
- Background:
Traditionally, contact allergy to aluminium has been established by patch testing with aluminium chloride hexahydrate in petrolatum at 2.0% and an empty Finn Chamber®.
Objectives:
The aim of this study was to investigate different aluminium test preparations regarding an optimal compound and an optimal test concentration. Methods. Six different aluminium compounds and an empty Finn Chamber® were used to patch test 21 patients with aluminium contact allergy. Aluminium chloride hexahydrate in saline was used for intracutaneous injection of 19 patients.
Results:
One test preparation, aluminium lactate 2.4%, was found to show significantly more positive patch test... (More) - Background:
Traditionally, contact allergy to aluminium has been established by patch testing with aluminium chloride hexahydrate in petrolatum at 2.0% and an empty Finn Chamber®.
Objectives:
The aim of this study was to investigate different aluminium test preparations regarding an optimal compound and an optimal test concentration. Methods. Six different aluminium compounds and an empty Finn Chamber® were used to patch test 21 patients with aluminium contact allergy. Aluminium chloride hexahydrate in saline was used for intracutaneous injection of 19 patients.
Results:
One test preparation, aluminium lactate 2.4%, was found to show significantly more positive patch test reactions than aluminium chloride hexahydrate 2.0% (p = 0.03). Aluminium chloride hexahydrate at 10.0% pet. gave the highest number of positive reactions to aluminium [14/21 (67%)]. No positive reactions were noted to an empty Finn Chamber®, and 3 of 19 (16%) patients reacted positively to the intradermal test.
Conclusions:
The results of this study indicate that patch testing with aluminium chloride hexahydrate 2.0%, with an empty Finn Chamber® and the intradermal test with the salt and doses used are insufficient methods to detect contact allergy to aluminium. Aluminium chloride hexahydrate at 10.0% gave the highest number of positive reactions to aluminium. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2608770
- author
- Siemund, Ingrid LU ; Zimerson, Erik LU ; Hindsén, Monica LU and Bruze, Magnus LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Contact Dermatitis
- volume
- 67
- issue
- 3
- pages
- 162 - 170
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000307846500007
- pmid:22594839
- scopus:84865240313
- pmid:22594839
- ISSN
- 0105-1873
- DOI
- 10.1111/j.1600-0536.2012.02084.x
- language
- English
- LU publication?
- yes
- id
- e8d09e4d-f5b0-49e4-b2dc-47ec0e7ca083 (old id 2608770)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22594839?dopt=Abstract
- date added to LUP
- 2016-04-04 07:54:16
- date last changed
- 2022-07-24 18:44:20
@article{e8d09e4d-f5b0-49e4-b2dc-47ec0e7ca083,
abstract = {{Background:<br/><br>
Traditionally, contact allergy to aluminium has been established by patch testing with aluminium chloride hexahydrate in petrolatum at 2.0% and an empty Finn Chamber®. <br/><br>
<br/><br>
Objectives:<br/><br>
The aim of this study was to investigate different aluminium test preparations regarding an optimal compound and an optimal test concentration. Methods. Six different aluminium compounds and an empty Finn Chamber® were used to patch test 21 patients with aluminium contact allergy. Aluminium chloride hexahydrate in saline was used for intracutaneous injection of 19 patients. <br/><br>
<br/><br>
Results:<br/><br>
One test preparation, aluminium lactate 2.4%, was found to show significantly more positive patch test reactions than aluminium chloride hexahydrate 2.0% (p = 0.03). Aluminium chloride hexahydrate at 10.0% pet. gave the highest number of positive reactions to aluminium [14/21 (67%)]. No positive reactions were noted to an empty Finn Chamber®, and 3 of 19 (16%) patients reacted positively to the intradermal test. <br/><br>
<br/><br>
Conclusions:<br/><br>
The results of this study indicate that patch testing with aluminium chloride hexahydrate 2.0%, with an empty Finn Chamber® and the intradermal test with the salt and doses used are insufficient methods to detect contact allergy to aluminium. Aluminium chloride hexahydrate at 10.0% gave the highest number of positive reactions to aluminium.}},
author = {{Siemund, Ingrid and Zimerson, Erik and Hindsén, Monica and Bruze, Magnus}},
issn = {{0105-1873}},
language = {{eng}},
number = {{3}},
pages = {{162--170}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Establishing aluminium contact allergy.}},
url = {{http://dx.doi.org/10.1111/j.1600-0536.2012.02084.x}},
doi = {{10.1111/j.1600-0536.2012.02084.x}},
volume = {{67}},
year = {{2012}},
}