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A biokinetic and dosimetric model for ionic indium in humans

Andersson, Martin LU ; Mattsson, Sören LU ; Johansson, Lennart and Leide-Svegborn, Sigrid LU (2017) In Physics in Medicine and Biology 62(16). p.6397-6407
Abstract

This paper reviews biokinetic data for ionic indium, and proposes a biokinetic model for systemic indium in adult humans. The development of parameter values focuses on human data and indium in the form of ionic indium(III), as indium chloride and indium arsenide. The model presented for systemic indium is defined by five different pools: plasma, bone marrow, liver, kidneys and other soft tissues. The model is based on two subsystems: one corresponding to indium bound to transferrin and one where indium is transported back to the plasma, binds to red blood cell transferrin and is then excreted through the kidneys to the urinary bladder. Absorbed doses to several organs and the effective dose are calculated for 111In- and... (More)

This paper reviews biokinetic data for ionic indium, and proposes a biokinetic model for systemic indium in adult humans. The development of parameter values focuses on human data and indium in the form of ionic indium(III), as indium chloride and indium arsenide. The model presented for systemic indium is defined by five different pools: plasma, bone marrow, liver, kidneys and other soft tissues. The model is based on two subsystems: one corresponding to indium bound to transferrin and one where indium is transported back to the plasma, binds to red blood cell transferrin and is then excreted through the kidneys to the urinary bladder. Absorbed doses to several organs and the effective dose are calculated for 111In- and 113mIn-ions. The proposed biokinetic model is compared with previously published biokinetic indium models published by the ICRP. The absorbed doses are calculated using the ICRP/ICRU adult reference phantoms and the effective dose is estimated according to ICRP Publication 103. The effective doses for 111In and 113mIn are 0.25 mSv MBq-1 and 0.013 mSv MBq-1 respectively. The updated biokinetic and dosimetric models presented in this paper take into account human data and new animal data, which represent more detailed and presumably more accurate dosimetric data than that underlying previous models for indium.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
absorbed dsoe, biokinetic model, effective dose, indium
in
Physics in Medicine and Biology
volume
62
issue
16
pages
11 pages
publisher
IOP Publishing
external identifiers
  • scopus:85026788703
ISSN
0031-9155
DOI
10.1088/1361-6560/aa779f
language
English
LU publication?
yes
id
e8e4b816-b8fa-4b39-96f6-1084dd952507
date added to LUP
2017-08-25 15:45:54
date last changed
2017-08-26 03:00:03
@article{e8e4b816-b8fa-4b39-96f6-1084dd952507,
  abstract     = {<p>This paper reviews biokinetic data for ionic indium, and proposes a biokinetic model for systemic indium in adult humans. The development of parameter values focuses on human data and indium in the form of ionic indium(III), as indium chloride and indium arsenide. The model presented for systemic indium is defined by five different pools: plasma, bone marrow, liver, kidneys and other soft tissues. The model is based on two subsystems: one corresponding to indium bound to transferrin and one where indium is transported back to the plasma, binds to red blood cell transferrin and is then excreted through the kidneys to the urinary bladder. Absorbed doses to several organs and the effective dose are calculated for <sup>111</sup>In- and <sup>113m</sup>In-ions. The proposed biokinetic model is compared with previously published biokinetic indium models published by the ICRP. The absorbed doses are calculated using the ICRP/ICRU adult reference phantoms and the effective dose is estimated according to ICRP Publication 103. The effective doses for <sup>111</sup>In and <sup>113m</sup>In are 0.25 mSv MBq<sup>-1</sup> and 0.013 mSv MBq<sup>-1</sup> respectively. The updated biokinetic and dosimetric models presented in this paper take into account human data and new animal data, which represent more detailed and presumably more accurate dosimetric data than that underlying previous models for indium.</p>},
  author       = {Andersson, Martin and Mattsson, Sören and Johansson, Lennart and Leide-Svegborn, Sigrid},
  issn         = {0031-9155},
  keyword      = {absorbed dsoe,biokinetic model,effective dose,indium},
  language     = {eng},
  month        = {07},
  number       = {16},
  pages        = {6397--6407},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {A biokinetic and dosimetric model for ionic indium in humans},
  url          = {http://dx.doi.org/10.1088/1361-6560/aa779f},
  volume       = {62},
  year         = {2017},
}