CSF studies in violent offenders. I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy
(2001) In Journal of Neural Transmission 108(7). p.869-878- Abstract
- Low serotonin activity in man has been related to impulsive, self-destructive violence but not to instrumental aggression aimed at dominance. A relationship has also been suggested between aggression and high catecholaminergic activity. Several studies have reported signs of aberrant dopaminergic function in attention deficit hyperactivity disorder, autism, and schizophrenia. In 22 violent offenders undergoing pretrial forensic psychiatric investigation, interpersonal and behavioral features of psychopathy, measured by the Psychopathy Checklist Revised (PCL-R), were significantly predicted by low cerebrospinal fluid (CSF) concentrations of 5-HIAA and high CSF concentrations of HVA in multivariate regression models. CSF concentrations of... (More)
- Low serotonin activity in man has been related to impulsive, self-destructive violence but not to instrumental aggression aimed at dominance. A relationship has also been suggested between aggression and high catecholaminergic activity. Several studies have reported signs of aberrant dopaminergic function in attention deficit hyperactivity disorder, autism, and schizophrenia. In 22 violent offenders undergoing pretrial forensic psychiatric investigation, interpersonal and behavioral features of psychopathy, measured by the Psychopathy Checklist Revised (PCL-R), were significantly predicted by low cerebrospinal fluid (CSF) concentrations of 5-HIAA and high CSF concentrations of HVA in multivariate regression models. CSF concentrations of MHPG did not contribute to the model. This seems to link the outward-directed aggression of psychopathy to serotonergic hypofunctioning and high dopamine turnover, which might account for disinhibition of destructive impulses. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1120703
- author
- Anckarsäter, Henrik LU ; Blennow, Kaj LU ; Manhem, A. and Forsman, A
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aggression, violence, psychopathy, serotonin, dopamine
- in
- Journal of Neural Transmission
- volume
- 108
- issue
- 7
- pages
- 869 - 878
- publisher
- Springer
- external identifiers
-
- pmid:11515752
- scopus:0034927718
- pmid:11515752
- ISSN
- 0300-9564
- DOI
- 10.1007/s007020170036
- language
- English
- LU publication?
- no
- id
- e90b2c78-35ae-495e-829f-5217f3445975 (old id 1120703)
- alternative location
- http://link.springer.com/article/10.1007%2Fs007020170036
- http://www.ncbi.nlm.nih.gov/pubmed/11515752
- date added to LUP
- 2016-04-01 16:50:05
- date last changed
- 2022-01-28 22:28:37
@article{e90b2c78-35ae-495e-829f-5217f3445975, abstract = {{Low serotonin activity in man has been related to impulsive, self-destructive violence but not to instrumental aggression aimed at dominance. A relationship has also been suggested between aggression and high catecholaminergic activity. Several studies have reported signs of aberrant dopaminergic function in attention deficit hyperactivity disorder, autism, and schizophrenia. In 22 violent offenders undergoing pretrial forensic psychiatric investigation, interpersonal and behavioral features of psychopathy, measured by the Psychopathy Checklist Revised (PCL-R), were significantly predicted by low cerebrospinal fluid (CSF) concentrations of 5-HIAA and high CSF concentrations of HVA in multivariate regression models. CSF concentrations of MHPG did not contribute to the model. This seems to link the outward-directed aggression of psychopathy to serotonergic hypofunctioning and high dopamine turnover, which might account for disinhibition of destructive impulses.}}, author = {{Anckarsäter, Henrik and Blennow, Kaj and Manhem, A. and Forsman, A}}, issn = {{0300-9564}}, keywords = {{Aggression; violence; psychopathy; serotonin; dopamine}}, language = {{eng}}, number = {{7}}, pages = {{869--878}}, publisher = {{Springer}}, series = {{Journal of Neural Transmission}}, title = {{CSF studies in violent offenders. I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy}}, url = {{http://dx.doi.org/10.1007/s007020170036}}, doi = {{10.1007/s007020170036}}, volume = {{108}}, year = {{2001}}, }