Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease
Gallo, Widet LU
; Ottosson, Filip
LU
; Kennbäck, Cecilia
LU
; Jujic, Amra
LU
; Esguerra, Jonathan LS
LU
; Eliasson, Lena
LU
and Melander, Olle
LU
(2021)
In BMC Cardiovascular Disorders
21.
- Abstract
- Background
Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case–control sample from the populations-based Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC). We here aimed at replicating these findings and to test for association with carotid atherosclerosis.
Methods
We measured miR-483-5p in fasting serum of 1223 healthy subjects from the baseline examination of the population-based, prospective cohort study Malmö Offspring Study (MOS) and... (More) - Background
Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case–control sample from the populations-based Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC). We here aimed at replicating these findings and to test for association with carotid atherosclerosis.
Methods
We measured miR-483-5p in fasting serum of 1223 healthy subjects from the baseline examination of the population-based, prospective cohort study Malmö Offspring Study (MOS) and correlated miR-483-5p to cardiometabolic risk factors and to incidence of diabetes mellitus and coronary artery disease (CAD) during 3.7 (± 1.3) years of follow-up using logistic regression. In both MOS and MDC-CC we related mir-483-5p to carotid atherosclerosis measured with ultrasound.
Results
In cross-sectional analysis miR-483-5p was correlated with BMI, waist circumference, HDL, and sex. After adjustment for age and sex, the association remained significant for all risk factors except for HDL. Logistic regression analysis showed significant associations between miR-483-5p and new-onset diabetes (OR = 1.94, 95% CI 1.06–3.56, p = 0.032) and cardiovascular disease (OR = 1.99, 95% CI 1.06–3.75, p = 0.033) during 3.7 (± 1.3) years of follow-up. Furthermore, miR-483-5p was significantly related with maximum intima-media thickness of the carotid bulb in MDC-CC (p = 0.001), but not in MOS, whereas it was associated with increasing number of plaques in MOS (p = 0.007).
Conclusion
miR-483-5p is related to an unfavorable cardiometabolic risk factor profile and predicts diabetes and CAD, possibly through an effect on atherosclerosis. Our results encourage further studies of possible underlying mechanisms and means of modifying miR-483-5p as a possible interventional target in prevention of cardiometabolic disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e93ec91d-13e6-404e-a6bd-722cc38c774a
- author
- Gallo, Widet
LU
; Ottosson, Filip
LU
; Kennbäck, Cecilia
LU
; Jujic, Amra
LU
; Esguerra, Jonathan LS
LU
; Eliasson, Lena
LU
and Melander, Olle
LU
- organization
- publishing date
- 2021-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Cardiovascular Disorders
- volume
- 21
- article number
- 162
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:33794782
- pmid:33794782
- scopus:85103807617
- ISSN
- 1471-2261
- DOI
- 10.1186/s12872-021-01964-0
- project
- AIR Lund - Artificially Intelligent use of Registers
- MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
- language
- English
- LU publication?
- yes
- id
- e93ec91d-13e6-404e-a6bd-722cc38c774a
- date added to LUP
- 2021-04-06 11:36:23
- date last changed
- 2024-01-05 07:52:27
@article{e93ec91d-13e6-404e-a6bd-722cc38c774a,
abstract = {{Background<br/><br/>Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case–control sample from the populations-based Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC). We here aimed at replicating these findings and to test for association with carotid atherosclerosis.<br/>Methods<br/><br/>We measured miR-483-5p in fasting serum of 1223 healthy subjects from the baseline examination of the population-based, prospective cohort study Malmö Offspring Study (MOS) and correlated miR-483-5p to cardiometabolic risk factors and to incidence of diabetes mellitus and coronary artery disease (CAD) during 3.7 (± 1.3) years of follow-up using logistic regression. In both MOS and MDC-CC we related mir-483-5p to carotid atherosclerosis measured with ultrasound.<br/>Results<br/><br/>In cross-sectional analysis miR-483-5p was correlated with BMI, waist circumference, HDL, and sex. After adjustment for age and sex, the association remained significant for all risk factors except for HDL. Logistic regression analysis showed significant associations between miR-483-5p and new-onset diabetes (OR = 1.94, 95% CI 1.06–3.56, p = 0.032) and cardiovascular disease (OR = 1.99, 95% CI 1.06–3.75, p = 0.033) during 3.7 (± 1.3) years of follow-up. Furthermore, miR-483-5p was significantly related with maximum intima-media thickness of the carotid bulb in MDC-CC (p = 0.001), but not in MOS, whereas it was associated with increasing number of plaques in MOS (p = 0.007).<br/>Conclusion<br/><br/>miR-483-5p is related to an unfavorable cardiometabolic risk factor profile and predicts diabetes and CAD, possibly through an effect on atherosclerosis. Our results encourage further studies of possible underlying mechanisms and means of modifying miR-483-5p as a possible interventional target in prevention of cardiometabolic disease.}},
author = {{Gallo, Widet and Ottosson, Filip and Kennbäck, Cecilia and Jujic, Amra and Esguerra, Jonathan LS and Eliasson, Lena and Melander, Olle}},
issn = {{1471-2261}},
language = {{eng}},
month = {{04}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cardiovascular Disorders}},
title = {{Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease}},
url = {{http://dx.doi.org/10.1186/s12872-021-01964-0}},
doi = {{10.1186/s12872-021-01964-0}},
volume = {{21}},
year = {{2021}},
}