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Conversion between NMSS and MDS-NMS in Parkinson's Disease

Garon, Michela ; Rojo-Albuin, José Manuel ; Chaudhuri, K. Ray ; Rizos, Alexandra ; Rodriguez-Blazquez, Carmen ; Mamikonyan, Eugenia ; Biundo, Roberta ; Schrag, Anette ; Weintraub, Daniel and Antonini, Angelo , et al. (2025) In Movement Disorders 40(5). p.813-820
Abstract

Background: The burden of non-motor symptoms in Parkinson's disease (PD) can be measured with the Non-Motor Symptoms Scale (NMSS) and the International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), for which scoring systems, structure and clinical coverage differ. Objectives: The goal was to develop conversion formulas between the NMSS and the MDS-NMS scores. Methods: Data from 402 patients with PD participating in the primary MDS-NMS validation study were used. The association between domain and total scores of both scales was assessed by the Spearman rank correlation coefficient and Kendall's W concordance coefficient. Equations for between-scale transformation of total score were constructed from weighted... (More)

Background: The burden of non-motor symptoms in Parkinson's disease (PD) can be measured with the Non-Motor Symptoms Scale (NMSS) and the International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), for which scoring systems, structure and clinical coverage differ. Objectives: The goal was to develop conversion formulas between the NMSS and the MDS-NMS scores. Methods: Data from 402 patients with PD participating in the primary MDS-NMS validation study were used. The association between domain and total scores of both scales was assessed by the Spearman rank correlation coefficient and Kendall's W concordance coefficient. Equations for between-scale transformation of total score were constructed from weighted linear regression models. Results: Spearman rank correlations showed that MDS-NMS domains correlated 0.39 to 0.88 with the corresponding NMSS domains. The equation for transforming the NMSS total score to MDS-NMS total score is: MDS-NMS = 11.629 + 1.624 × NMSS (P < 0.001, R2 = 0.748). For converting the MDS-NMS total score to NMSS total score, the formula is NMSS = 2.475 + 0.495 × MDS-NMS (P < 0.001, R2 = 0.771). Conclusions: Our conversion equations enable direct comparison of the NMSS and MDS-NMS instruments, facilitating data comparability across studies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
conversion formulas, movement disorders, non-motor symptoms, Parkinson's disease, rating scales
in
Movement Disorders
volume
40
issue
5
pages
8 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:105000833878
  • pmid:40110732
ISSN
0885-3185
DOI
10.1002/mds.30172
language
English
LU publication?
yes
id
e9631e27-b19a-44fd-b321-73b433cb1185
date added to LUP
2025-09-12 08:49:11
date last changed
2025-09-12 09:41:41
@article{e9631e27-b19a-44fd-b321-73b433cb1185,
  abstract     = {{<p>Background: The burden of non-motor symptoms in Parkinson's disease (PD) can be measured with the Non-Motor Symptoms Scale (NMSS) and the International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), for which scoring systems, structure and clinical coverage differ. Objectives: The goal was to develop conversion formulas between the NMSS and the MDS-NMS scores. Methods: Data from 402 patients with PD participating in the primary MDS-NMS validation study were used. The association between domain and total scores of both scales was assessed by the Spearman rank correlation coefficient and Kendall's W concordance coefficient. Equations for between-scale transformation of total score were constructed from weighted linear regression models. Results: Spearman rank correlations showed that MDS-NMS domains correlated 0.39 to 0.88 with the corresponding NMSS domains. The equation for transforming the NMSS total score to MDS-NMS total score is: MDS-NMS = 11.629 + 1.624 × NMSS (P &lt; 0.001, R<sup>2</sup> = 0.748). For converting the MDS-NMS total score to NMSS total score, the formula is NMSS = 2.475 + 0.495 × MDS-NMS (P &lt; 0.001, R<sup>2</sup> = 0.771). Conclusions: Our conversion equations enable direct comparison of the NMSS and MDS-NMS instruments, facilitating data comparability across studies.</p>}},
  author       = {{Garon, Michela and Rojo-Albuin, José Manuel and Chaudhuri, K. Ray and Rizos, Alexandra and Rodriguez-Blazquez, Carmen and Mamikonyan, Eugenia and Biundo, Roberta and Schrag, Anette and Weintraub, Daniel and Antonini, Angelo and Odin, Per and Martinez-Martin, Pablo}},
  issn         = {{0885-3185}},
  keywords     = {{conversion formulas; movement disorders; non-motor symptoms; Parkinson's disease; rating scales}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{813--820}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Movement Disorders}},
  title        = {{Conversion between NMSS and MDS-NMS in Parkinson's Disease}},
  url          = {{http://dx.doi.org/10.1002/mds.30172}},
  doi          = {{10.1002/mds.30172}},
  volume       = {{40}},
  year         = {{2025}},
}