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Response of the carotid artery longitudinal motion to submaximal physical activity in healthy humans-Marked changes already at low workload

Ahlgren, Åsa Rydén LU orcid ; Erlöv, Tobias LU and Cinthio, Magnus LU (2023) In Physiological Reports 11(2).
Abstract

The longitudinal motion of the arterial wall, that is, the displacement of the arterial wall along the artery, parallel to blood flow, is still largely unexplored. The magnitude and nature of putative changes in longitudinal motion of the arterial wall in response to physical activity in humans remain unknown. The aim of this study was therefore to study the longitudinal motion of the carotid artery wall during physical activity in healthy humans. Using in-house developed non-invasive ultrasonic methods, the longitudinal motion of the intima-media complex and the diameter changes of the right common carotid artery (CCA) in 40 healthy volunteers (20 volunteers aged 22-35 years; 20 volunteers aged 55-68 years) were assessed at rest and... (More)

The longitudinal motion of the arterial wall, that is, the displacement of the arterial wall along the artery, parallel to blood flow, is still largely unexplored. The magnitude and nature of putative changes in longitudinal motion of the arterial wall in response to physical activity in humans remain unknown. The aim of this study was therefore to study the longitudinal motion of the carotid artery wall during physical activity in healthy humans. Using in-house developed non-invasive ultrasonic methods, the longitudinal motion of the intima-media complex and the diameter changes of the right common carotid artery (CCA) in 40 healthy volunteers (20 volunteers aged 22-35 years; 20 volunteers aged 55-68 years) were assessed at rest and during submaximal supine bicycle exercise. In a subset of the subjects (n = 18) also intramural shear strain were analyzed. The longitudinal motion of the intima-media complex underwent marked changes in response to physical activity, already at low workload; with most evident a marked increase of the first antegrade displacement (p < 0.001) in early systole. Likewise, the corresponding shear strain also increased significantly (p = 0.004). The increase in longitudinal motion showed significant correlation to increase in blood pressure, but not to blood flow velocity or wall shear stress. In conclusion, physical activity markedly influences the longitudinal motion of the carotid artery wall in healthy humans already at low load. A possible "cushioning" function as well as possible implications for the function of the vasa vasorum, endothelium, and smooth muscle cells and extracellular matrix of the media, are discussed.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physiological Reports
volume
11
issue
2
article number
e15580
pages
17 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:36702558
  • scopus:85146934897
ISSN
2051-817X
DOI
10.14814/phy2.15580
language
English
LU publication?
yes
id
e98ab6ae-d77f-40c0-bd4b-848f0ff0acdd
date added to LUP
2023-01-28 09:02:09
date last changed
2024-06-13 23:23:29
@article{e98ab6ae-d77f-40c0-bd4b-848f0ff0acdd,
  abstract     = {{<p>The longitudinal motion of the arterial wall, that is, the displacement of the arterial wall along the artery, parallel to blood flow, is still largely unexplored. The magnitude and nature of putative changes in longitudinal motion of the arterial wall in response to physical activity in humans remain unknown. The aim of this study was therefore to study the longitudinal motion of the carotid artery wall during physical activity in healthy humans. Using in-house developed non-invasive ultrasonic methods, the longitudinal motion of the intima-media complex and the diameter changes of the right common carotid artery (CCA) in 40 healthy volunteers (20 volunteers aged 22-35 years; 20 volunteers aged 55-68 years) were assessed at rest and during submaximal supine bicycle exercise. In a subset of the subjects (n = 18) also intramural shear strain were analyzed. The longitudinal motion of the intima-media complex underwent marked changes in response to physical activity, already at low workload; with most evident a marked increase of the first antegrade displacement (p &lt; 0.001) in early systole. Likewise, the corresponding shear strain also increased significantly (p = 0.004). The increase in longitudinal motion showed significant correlation to increase in blood pressure, but not to blood flow velocity or wall shear stress. In conclusion, physical activity markedly influences the longitudinal motion of the carotid artery wall in healthy humans already at low load. A possible "cushioning" function as well as possible implications for the function of the vasa vasorum, endothelium, and smooth muscle cells and extracellular matrix of the media, are discussed.</p>}},
  author       = {{Ahlgren, Åsa Rydén and Erlöv, Tobias and Cinthio, Magnus}},
  issn         = {{2051-817X}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Physiological Reports}},
  title        = {{Response of the carotid artery longitudinal motion to submaximal physical activity in healthy humans-Marked changes already at low workload}},
  url          = {{http://dx.doi.org/10.14814/phy2.15580}},
  doi          = {{10.14814/phy2.15580}},
  volume       = {{11}},
  year         = {{2023}},
}