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Tumor growth rate estimations in a breast cancer screening population

Tomic, Hanna LU ; Ohashi, Akane LU ; Dahlblom, Victor LU orcid ; Bjerkén, Anna LU orcid ; Förnvik, Daniel LU ; Dustler, Magnus LU ; Zackrisson, Sophia LU ; Tingberg, Anders LU and Bakic, Predrag LU (2022) 16th International Workshop on Breast Imaging, IWBI 2022 In Proceedings of SPIE - The International Society for Optical Engineering 12286.
Abstract

Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Screening Trial (MBTST). The trial included 14 848 women in whom 139 cancers were detected. Out of those, 101 spiculated or circumscribed masses, had prior images available, making them suitable for tumor growth evaluation. In the preliminary analysis of images from 30 women, tumor size was measured in mammograms from MBTST and prior images. The... (More)

Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Screening Trial (MBTST). The trial included 14 848 women in whom 139 cancers were detected. Out of those, 101 spiculated or circumscribed masses, had prior images available, making them suitable for tumor growth evaluation. In the preliminary analysis of images from 30 women, tumor size was measured in mammograms from MBTST and prior images. The analyzed cases were selected among women with visible tumors in two consecutive screening exams. The tumor size was measured in two orthogonal directions. The average of the two measurements was used in the analysis. The mean time and the corresponding standard deviation (SD) between the two consecutive mammograms were 744 ± 73 days. The mean TVDT and SD were 637 ± 428 days (range 159-2373 days). Future work will include the analysis of a larger number of women and a stratification of TVDT related to screening intervals.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
breast cancer, Tumor growth, tumor volume doubling time
host publication
16th International Workshop on Breast Imaging, IWBI 2022
series title
Proceedings of SPIE - The International Society for Optical Engineering
editor
Bosmans, Hilde ; Marshall, Nicholas and Van Ongeval, Chantal
volume
12286
article number
1228613
publisher
SPIE
conference name
16th International Workshop on Breast Imaging, IWBI 2022
conference location
Leuven, Belgium
conference dates
2022-05-22 - 2022-05-25
external identifiers
  • scopus:85136113683
ISSN
1996-756X
0277-786X
ISBN
9781510655843
DOI
10.1117/12.2625730
language
English
LU publication?
yes
id
e9c618e7-ccf4-4f78-86ae-d1593ea34cc1
date added to LUP
2022-10-07 13:31:15
date last changed
2024-04-04 12:35:48
@inproceedings{e9c618e7-ccf4-4f78-86ae-d1593ea34cc1,
  abstract     = {{<p>Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Screening Trial (MBTST). The trial included 14 848 women in whom 139 cancers were detected. Out of those, 101 spiculated or circumscribed masses, had prior images available, making them suitable for tumor growth evaluation. In the preliminary analysis of images from 30 women, tumor size was measured in mammograms from MBTST and prior images. The analyzed cases were selected among women with visible tumors in two consecutive screening exams. The tumor size was measured in two orthogonal directions. The average of the two measurements was used in the analysis. The mean time and the corresponding standard deviation (SD) between the two consecutive mammograms were 744 ± 73 days. The mean TVDT and SD were 637 ± 428 days (range 159-2373 days). Future work will include the analysis of a larger number of women and a stratification of TVDT related to screening intervals. </p>}},
  author       = {{Tomic, Hanna and Ohashi, Akane and Dahlblom, Victor and Bjerkén, Anna and Förnvik, Daniel and Dustler, Magnus and Zackrisson, Sophia and Tingberg, Anders and Bakic, Predrag}},
  booktitle    = {{16th International Workshop on Breast Imaging, IWBI 2022}},
  editor       = {{Bosmans, Hilde and Marshall, Nicholas and Van Ongeval, Chantal}},
  isbn         = {{9781510655843}},
  issn         = {{1996-756X}},
  keywords     = {{breast cancer; Tumor growth; tumor volume doubling time}},
  language     = {{eng}},
  publisher    = {{SPIE}},
  series       = {{Proceedings of SPIE - The International Society for Optical Engineering}},
  title        = {{Tumor growth rate estimations in a breast cancer screening population}},
  url          = {{http://dx.doi.org/10.1117/12.2625730}},
  doi          = {{10.1117/12.2625730}},
  volume       = {{12286}},
  year         = {{2022}},
}