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Snus use and risk of schizophrenia and non-affective psychosis

Munafò, Marcus R.; Larsson Lönn, Sara LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Kendler, Kenneth (2016) In Drug and Alcohol Dependence 164. p.179-182
Abstract

Background: Recent studies suggest a possible causal role for smoking in schizophrenia and psychosis. Most studies have focused on cigarette smoking, the most common form of tobacco use, but other forms of tobacco exist, including smokeless products such as Swedish snuff (or "snus"). Methods: We explored whether snus use is associated with schizophrenia and non-affective psychotic illness in a large Swedish registry data set. The majority of participants were aged 18 or 19 at the time of assessment. Results: We observed a positive association between snus use and odds of schizophrenia in all analyses, but the magnitude of the association was small and the confidence interval wide, consistent with no association (fully adjusted HR 1.03,... (More)

Background: Recent studies suggest a possible causal role for smoking in schizophrenia and psychosis. Most studies have focused on cigarette smoking, the most common form of tobacco use, but other forms of tobacco exist, including smokeless products such as Swedish snuff (or "snus"). Methods: We explored whether snus use is associated with schizophrenia and non-affective psychotic illness in a large Swedish registry data set. The majority of participants were aged 18 or 19 at the time of assessment. Results: We observed a positive association between snus use and odds of schizophrenia in all analyses, but the magnitude of the association was small and the confidence interval wide, consistent with no association (fully adjusted HR 1.03, 95% 0.70-1.54). A similar pattern was observed for non-affective psychosis, but the magnitude of the association was somewhat greater and the confidence intervals narrower, so that these analyses provided stronger statistical evidence for this association (fully adjusted HR 1.22, 95% CI, 1.00-1.48). Conclusions: Our results therefore provide modest evidence for an association between snus use and risk for non-affective psychosis. This is consistent with emerging evidence from a range of studies and methodologies that tobacco use may be a risk factor for psychotic illness. However, our results provide some evidence against the hypothesis that it is the burnt products of cigarette smoke that are psychotogenic.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Non-affective psychosis, Schizophrenia, Snus, Tobacco
in
Drug and Alcohol Dependence
volume
164
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:84965157958
  • wos:000378468800024
ISSN
0376-8716
DOI
10.1016/j.drugalcdep.2016.04.035
language
English
LU publication?
yes
id
ea40b9b7-256b-4653-a1bb-b828e9f05da2
date added to LUP
2017-01-23 14:44:45
date last changed
2017-09-18 11:33:22
@article{ea40b9b7-256b-4653-a1bb-b828e9f05da2,
  abstract     = {<p>Background: Recent studies suggest a possible causal role for smoking in schizophrenia and psychosis. Most studies have focused on cigarette smoking, the most common form of tobacco use, but other forms of tobacco exist, including smokeless products such as Swedish snuff (or "snus"). Methods: We explored whether snus use is associated with schizophrenia and non-affective psychotic illness in a large Swedish registry data set. The majority of participants were aged 18 or 19 at the time of assessment. Results: We observed a positive association between snus use and odds of schizophrenia in all analyses, but the magnitude of the association was small and the confidence interval wide, consistent with no association (fully adjusted HR 1.03, 95% 0.70-1.54). A similar pattern was observed for non-affective psychosis, but the magnitude of the association was somewhat greater and the confidence intervals narrower, so that these analyses provided stronger statistical evidence for this association (fully adjusted HR 1.22, 95% CI, 1.00-1.48). Conclusions: Our results therefore provide modest evidence for an association between snus use and risk for non-affective psychosis. This is consistent with emerging evidence from a range of studies and methodologies that tobacco use may be a risk factor for psychotic illness. However, our results provide some evidence against the hypothesis that it is the burnt products of cigarette smoke that are psychotogenic.</p>},
  author       = {Munafò, Marcus R. and Larsson Lönn, Sara and Sundquist, Jan and Sundquist, Kristina and Kendler, Kenneth},
  issn         = {0376-8716},
  keyword      = {Non-affective psychosis,Schizophrenia,Snus,Tobacco},
  language     = {eng},
  month        = {07},
  pages        = {179--182},
  publisher    = {Elsevier},
  series       = {Drug and Alcohol Dependence},
  title        = {Snus use and risk of schizophrenia and non-affective psychosis},
  url          = {http://dx.doi.org/10.1016/j.drugalcdep.2016.04.035},
  volume       = {164},
  year         = {2016},
}