Advanced

Blood levels of cadmium and lead in relation to breast cancer risk in three prospective cohorts

Gaudet, Mia M.; Deubler, Emily L.; Kelly, Rachel S.; Ryan Diver, W.; Teras, Lauren R.; Hodge, James M.; Levine, Keith E.; Haines, Laura G.; Lundh, Thomas LU and Lenner, Per, et al. (2019) In International Journal of Cancer 144(5). p.1010-1016
Abstract

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case–control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition – Italy (EPIC-Italy) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma-mass spectrometry. Summary relative risks... (More)

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case–control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition – Italy (EPIC-Italy) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma-mass spectrometry. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models with each study result weighted by the within- and between-study variances. I2 values were calculated to estimate proportion of between study variation. Using common cut-points, cadmium levels were not associated with breast cancer risk in the CPS-II cohort (continuous RR = 1.01, 95% CI 0.76–1.34), but were inversely associated with risk in the EPIC- Italy (continuous RR = 0.80, 95% CI 0.61–1.03) and NSHDS cohorts (continuous RR = 0.73, 95% CI 0.54–0.97). The inverse association was also evident in the meta-analysis (continuous RR = 0.84, 95% CI 0.69–1.01) with low between-study heterogeneity. Large differences in lead level distributions precluded a meta-analysis of their association with breast cancer risk; no associations were found in the three studies. Adult cadmium and lead levels were not associated with higher risk of breast cancer in our large meta-analysis.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, cadmium, lead
in
International Journal of Cancer
volume
144
issue
5
pages
1010 - 1016
publisher
John Wiley & Sons
external identifiers
  • scopus:85056318060
ISSN
0020-7136
DOI
10.1002/ijc.31805
language
English
LU publication?
yes
id
ea5fa34e-d329-494a-99f2-20cd01768408
date added to LUP
2018-11-26 08:07:27
date last changed
2019-01-16 11:46:12
@article{ea5fa34e-d329-494a-99f2-20cd01768408,
  abstract     = {<p>Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case–control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition – Italy (EPIC-Italy) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma-mass spectrometry. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models with each study result weighted by the within- and between-study variances. I<sup>2</sup> values were calculated to estimate proportion of between study variation. Using common cut-points, cadmium levels were not associated with breast cancer risk in the CPS-II cohort (continuous RR = 1.01, 95% CI 0.76–1.34), but were inversely associated with risk in the EPIC- Italy (continuous RR = 0.80, 95% CI 0.61–1.03) and NSHDS cohorts (continuous RR = 0.73, 95% CI 0.54–0.97). The inverse association was also evident in the meta-analysis (continuous RR = 0.84, 95% CI 0.69–1.01) with low between-study heterogeneity. Large differences in lead level distributions precluded a meta-analysis of their association with breast cancer risk; no associations were found in the three studies. Adult cadmium and lead levels were not associated with higher risk of breast cancer in our large meta-analysis.</p>},
  author       = {Gaudet, Mia M. and Deubler, Emily L. and Kelly, Rachel S. and Ryan Diver, W. and Teras, Lauren R. and Hodge, James M. and Levine, Keith E. and Haines, Laura G. and Lundh, Thomas and Lenner, Per and Palli, Domenico and Vineis, Paolo and Bergdahl, Ingvar A. and Gapstur, Susan M. and Kyrtopoulos, Soterios A.},
  issn         = {0020-7136},
  keyword      = {breast cancer,cadmium,lead},
  language     = {eng},
  month        = {03},
  number       = {5},
  pages        = {1010--1016},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Blood levels of cadmium and lead in relation to breast cancer risk in three prospective cohorts},
  url          = {http://dx.doi.org/10.1002/ijc.31805},
  volume       = {144},
  year         = {2019},
}