Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

Valind, Kristian LU orcid ; Jögi, Jonas LU orcid ; Minarik, David LU ; Brolin, Gustav LU and Trägårdh, Elin LU (2021) In EJNMMI Physics 8. p.1-11
Abstract
Background
In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity.

Methods
Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007... (More)
Background
In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity.

Methods
Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007 PET-CT at 8 time points up to 5.5 h post-injection (p.i.). List-mode data were binned to durations of 10 to 120 s per bed position (bp). Left renal percentage of total renal uptake (LRU%) was measured, and the difference between highest and lowest measurement per patient (“delta max”) was calculated. Images acquired at 1 h, 2 h, and 5.5 h p.i. with durations of 10 to 120 s/bp were rated regarding image quality.

Results
Imaging at 2 h p.i. with 60 s/bp yielded acceptable quality in all cases. Increasing acquisition time to 15 min for a single bp would allow reducing administered activity to 0.27 MBq/kg, resulting in an effective dose of 0.4 mSv for a 1-year old child weighing 10 kg. The median delta max of LRU% measurements was 2.7% (range 1.8–7.3%).

Conclusions
Renal [18F]PSMA-1007 PET-CT is feasible, with imaging 2 h p.i., acceptable split renal uptake variability, and effective dose and acquisition time comparable to those of [99mTc]Tc-DMSA scintigraphy. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PET-CT, PSMA, Renal function, Renal cortex, DMSA
in
EJNMMI Physics
volume
8
article number
70
pages
1 - 11
publisher
Springer
external identifiers
  • pmid:34714424
  • scopus:85118242271
ISSN
2197-7364
DOI
10.1186/s40658-021-00419-x
project
New methods for tomographic functional imaging of the renal cortex
language
English
LU publication?
yes
id
ea85295b-7a4b-4b2e-b82c-2dfc779b9e65
date added to LUP
2021-10-30 12:05:45
date last changed
2022-11-01 01:22:29
@article{ea85295b-7a4b-4b2e-b82c-2dfc779b9e65,
  abstract     = {{Background<br/>In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity.<br/><br/>Methods<br/>Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007 PET-CT at 8 time points up to 5.5 h post-injection (p.i.). List-mode data were binned to durations of 10 to 120 s per bed position (bp). Left renal percentage of total renal uptake (LRU%) was measured, and the difference between highest and lowest measurement per patient (“delta max”) was calculated. Images acquired at 1 h, 2 h, and 5.5 h p.i. with durations of 10 to 120 s/bp were rated regarding image quality.<br/><br/>Results<br/>Imaging at 2 h p.i. with 60 s/bp yielded acceptable quality in all cases. Increasing acquisition time to 15 min for a single bp would allow reducing administered activity to 0.27 MBq/kg, resulting in an effective dose of 0.4 mSv for a 1-year old child weighing 10 kg. The median delta max of LRU% measurements was 2.7% (range 1.8–7.3%).<br/><br/>Conclusions<br/>Renal [18F]PSMA-1007 PET-CT is feasible, with imaging 2 h p.i., acceptable split renal uptake variability, and effective dose and acquisition time comparable to those of [99mTc]Tc-DMSA scintigraphy.}},
  author       = {{Valind, Kristian and Jögi, Jonas and Minarik, David and Brolin, Gustav and Trägårdh, Elin}},
  issn         = {{2197-7364}},
  keywords     = {{PET-CT; PSMA; Renal function; Renal cortex; DMSA}},
  language     = {{eng}},
  pages        = {{1--11}},
  publisher    = {{Springer}},
  series       = {{EJNMMI Physics}},
  title        = {{Dose-reduced [<sup>18</sup>F]PSMA-1007 PET is feasible for functional imaging of the renal cortex}},
  url          = {{http://dx.doi.org/10.1186/s40658-021-00419-x}},
  doi          = {{10.1186/s40658-021-00419-x}},
  volume       = {{8}},
  year         = {{2021}},
}