Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex
(2021) In EJNMMI Physics 8. p.1-11- Abstract
- Background
In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity.
Methods
Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007... (More) - Background
In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity.
Methods
Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007 PET-CT at 8 time points up to 5.5 h post-injection (p.i.). List-mode data were binned to durations of 10 to 120 s per bed position (bp). Left renal percentage of total renal uptake (LRU%) was measured, and the difference between highest and lowest measurement per patient (“delta max”) was calculated. Images acquired at 1 h, 2 h, and 5.5 h p.i. with durations of 10 to 120 s/bp were rated regarding image quality.
Results
Imaging at 2 h p.i. with 60 s/bp yielded acceptable quality in all cases. Increasing acquisition time to 15 min for a single bp would allow reducing administered activity to 0.27 MBq/kg, resulting in an effective dose of 0.4 mSv for a 1-year old child weighing 10 kg. The median delta max of LRU% measurements was 2.7% (range 1.8–7.3%).
Conclusions
Renal [18F]PSMA-1007 PET-CT is feasible, with imaging 2 h p.i., acceptable split renal uptake variability, and effective dose and acquisition time comparable to those of [99mTc]Tc-DMSA scintigraphy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ea85295b-7a4b-4b2e-b82c-2dfc779b9e65
- author
- Valind, Kristian LU ; Jögi, Jonas LU ; Minarik, David LU ; Brolin, Gustav LU and Trägårdh, Elin LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- PET-CT, PSMA, Renal function, Renal cortex, DMSA
- in
- EJNMMI Physics
- volume
- 8
- article number
- 70
- pages
- 1 - 11
- publisher
- Springer
- external identifiers
-
- pmid:34714424
- scopus:85118242271
- ISSN
- 2197-7364
- DOI
- 10.1186/s40658-021-00419-x
- project
- New methods for tomographic functional imaging of the renal cortex
- language
- English
- LU publication?
- yes
- id
- ea85295b-7a4b-4b2e-b82c-2dfc779b9e65
- date added to LUP
- 2021-10-30 12:05:45
- date last changed
- 2022-11-01 01:22:29
@article{ea85295b-7a4b-4b2e-b82c-2dfc779b9e65, abstract = {{Background<br/>In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity.<br/><br/>Methods<br/>Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007 PET-CT at 8 time points up to 5.5 h post-injection (p.i.). List-mode data were binned to durations of 10 to 120 s per bed position (bp). Left renal percentage of total renal uptake (LRU%) was measured, and the difference between highest and lowest measurement per patient (“delta max”) was calculated. Images acquired at 1 h, 2 h, and 5.5 h p.i. with durations of 10 to 120 s/bp were rated regarding image quality.<br/><br/>Results<br/>Imaging at 2 h p.i. with 60 s/bp yielded acceptable quality in all cases. Increasing acquisition time to 15 min for a single bp would allow reducing administered activity to 0.27 MBq/kg, resulting in an effective dose of 0.4 mSv for a 1-year old child weighing 10 kg. The median delta max of LRU% measurements was 2.7% (range 1.8–7.3%).<br/><br/>Conclusions<br/>Renal [18F]PSMA-1007 PET-CT is feasible, with imaging 2 h p.i., acceptable split renal uptake variability, and effective dose and acquisition time comparable to those of [99mTc]Tc-DMSA scintigraphy.}}, author = {{Valind, Kristian and Jögi, Jonas and Minarik, David and Brolin, Gustav and Trägårdh, Elin}}, issn = {{2197-7364}}, keywords = {{PET-CT; PSMA; Renal function; Renal cortex; DMSA}}, language = {{eng}}, pages = {{1--11}}, publisher = {{Springer}}, series = {{EJNMMI Physics}}, title = {{Dose-reduced [<sup>18</sup>F]PSMA-1007 PET is feasible for functional imaging of the renal cortex}}, url = {{http://dx.doi.org/10.1186/s40658-021-00419-x}}, doi = {{10.1186/s40658-021-00419-x}}, volume = {{8}}, year = {{2021}}, }