Functional imaging of the renal cortex with 18F-PSMA-1007 PET
Valind, Kristian LU
(2026)
In Lund University, Faculty of Medicine Doctoral Dissertation Series
- Abstract
- Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (99mTc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long trend shows an ongoing shift from gamma camera imaging (such as with 99mTc-
DMSA) to positron emission tomography (PET), mainly due to higher technical performance. In this thesis, a PET radiopharmaceutical developed for prostate cancer imaging, 18F-PSMA-1007, was evaluated for use as a potential replacement for... (More) - Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (99mTc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long trend shows an ongoing shift from gamma camera imaging (such as with 99mTc-
DMSA) to positron emission tomography (PET), mainly due to higher technical performance. In this thesis, a PET radiopharmaceutical developed for prostate cancer imaging, 18F-PSMA-1007, was evaluated for use as a potential replacement for 99mTc-DMSA.
Methods: In paper I, 20 participants underwent both 18F-PSMA-1007 PET and 99mTc-DMSA scintigraphy. Images from both modalities were compared regarding SRF and presence of defects. In paper II, estimated glomerular filtration rate (eGFR) was calculated for 170 participants having undergone 18F-PSMA-1007 PET to investigate a potential correlation between eGFR and renal uptake. In paper III, different acquisition time-points for renal 18F-PSMA-1007 PET were evaluated
regarding image quality in a cohort of 12 participants having undergone multiple image acquisitions. For paper IV, an artificial intelligence (AI) model was developed, trained and evaluated for measurement of SRF in 18F-PSMA-1007 PET based on segmentation of 215 clinical cases.
Results: The same number of uptake defects were found using 99mTc-DMSA scintigraphy and 18F-PSMA-1007 PET. There was excellent correlation regarding SRF (r = 0.95). A moderate association (R2 = 0.556) was found between eGFR and renal uptake of 18F-PSMA-1007. The optimal time-point for renal imaging was 2 hours after injection of 18F-PSMA-1007. The AI model performed similarly to human readers, making automatic measurement of SRF in clinical 18F-PSMA-1007 PET feasible.
Conclusion: Functional imaging of the renal cortex using 18F-PSMA-1007 PET is feasible, with performance similar to that of 99mTc-DMSA scintigraphy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ef0cbd05-5a08-4533-8a00-c20f18a5396e
- author
- Valind, Kristian
LU
- supervisor
-
- Elin Trägårdh LU
- Jonas Jögi LU
- opponent
-
- Professor Bernhardt, Peter, Gothenburg University
- organization
- publishing date
- 2026
- type
- Thesis
- publication status
- published
- subject
- keywords
- functional imaging, PET, DMSA, PSMA, renal cortex, artificial intellgience, glomerular filtration
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2026:40
- pages
- 87 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Föreläsningssal 1, Centralblocket, Entrégatan 7, Skånes Universitetssjukhus i Lund. Join by Zoom: https://lu-se.zoom.us/j/67265958757?pwd=NcNLcU6aD2kgt6WLuizDqH3WSZX6jT.1
- defense date
- 2026-05-28 13:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-838-2
- project
- Functional imaging of the renal cortex with 18F-PSMA-1007 PET
- language
- English
- LU publication?
- yes
- id
- ef0cbd05-5a08-4533-8a00-c20f18a5396e
- date added to LUP
- 2026-05-05 13:00:31
- date last changed
- 2026-05-05 13:15:08
@phdthesis{ef0cbd05-5a08-4533-8a00-c20f18a5396e,
abstract = {{Background: Scintigraphy of the renal cortex with technetium-99m labelled dimercaptosuccinic acid (<sup>99m</sup>Tc-DMSA) is well established in the follow-up of pyelonephritis in children. This method allows detection of focal defects of renal function, as well as measurement of the relative contribution of each kidney to total renal function - split renal function (SRF). Within nuclear medicine, the long trend shows an ongoing shift from gamma camera imaging (such as with <sup>99m</sup>Tc-<br/>DMSA) to positron emission tomography (PET), mainly due to higher technical performance. In this thesis, a PET radiopharmaceutical developed for prostate cancer imaging, <sup>18</sup>F-PSMA-1007, was evaluated for use as a potential replacement for <sup>99m</sup>Tc-DMSA.<br/><br/>Methods: In paper I, 20 participants underwent both <sup>18</sup>F-PSMA-1007 PET and <sup>99m</sup>Tc-DMSA scintigraphy. Images from both modalities were compared regarding SRF and presence of defects. In paper II, estimated glomerular filtration rate (eGFR) was calculated for 170 participants having undergone <sup>18</sup>F-PSMA-1007 PET to investigate a potential correlation between eGFR and renal uptake. In paper III, different acquisition time-points for renal <sup>18</sup>F-PSMA-1007 PET were evaluated<br/>regarding image quality in a cohort of 12 participants having undergone multiple image acquisitions. For paper IV, an artificial intelligence (AI) model was developed, trained and evaluated for measurement of SRF in <sup>18</sup>F-PSMA-1007 PET based on segmentation of 215 clinical cases. <br/><br/>Results: The same number of uptake defects were found using <sup>99m</sup>Tc-DMSA scintigraphy and <sup>18</sup>F-PSMA-1007 PET. There was excellent correlation regarding SRF (r = 0.95). A moderate association (R<sup>2</sup> = 0.556) was found between eGFR and renal uptake of <sup>18</sup>F-PSMA-1007. The optimal time-point for renal imaging was 2 hours after injection of <sup>18</sup>F-PSMA-1007. The AI model performed similarly to human readers, making automatic measurement of SRF in clinical <sup>18</sup>F-PSMA-1007 PET feasible.<br/><br/>Conclusion: Functional imaging of the renal cortex using <sup>18</sup>F-PSMA-1007 PET is feasible, with performance similar to that of <sup>99m</sup>Tc-DMSA scintigraphy.}},
author = {{Valind, Kristian}},
isbn = {{978-91-8021-838-2}},
issn = {{1652-8220}},
keywords = {{functional imaging; PET; DMSA; PSMA; renal cortex; artificial intellgience; glomerular filtration}},
language = {{eng}},
number = {{2026:40}},
publisher = {{Lund University, Faculty of Medicine}},
school = {{Lund University}},
series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}},
title = {{Functional imaging of the renal cortex with <sup>18</sup>F-PSMA-1007 PET}},
url = {{https://lup.lub.lu.se/search/files/249272428/Avhandling_fullst_ndig.pdf}},
year = {{2026}},
}