Towards engineered yeast as production platform for capsaicinoids
(2022) In Biotechnology Advances 59.- Abstract
- Capsaicinoids are bioactive alkaloids produced by the chili pepper fruit and are known to be the most potent agonists of the human pain receptor TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). They are currently produced by extraction from chili pepper fruit or by chemical synthesis. Transfer of the biosynthetic route to a microbial host could enable more efficient capsaicinoid production by fermentation and may also enable the use of synthetic biology to create a diversity of new compounds with potentially improved properties. This review summarises the current state of the art on the biosynthesis of capsaicinoid precursors in baker's yeast, Saccharomyces cerevisiae, and discusses bioengineering strategies... (More)
- Capsaicinoids are bioactive alkaloids produced by the chili pepper fruit and are known to be the most potent agonists of the human pain receptor TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). They are currently produced by extraction from chili pepper fruit or by chemical synthesis. Transfer of the biosynthetic route to a microbial host could enable more efficient capsaicinoid production by fermentation and may also enable the use of synthetic biology to create a diversity of new compounds with potentially improved properties. This review summarises the current state of the art on the biosynthesis of capsaicinoid precursors in baker's yeast, Saccharomyces cerevisiae, and discusses bioengineering strategies for achieving total synthesis from sugar. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ead08f5f-a550-4bd3-8c2a-de9f40ecb4a7
- author
- Muratovska, Nina LU ; Silva, Paulo ; Pozdniakova, Tatiana ; Pereira, Humberto ; Grey, Carl LU ; Johansson, Björn and Carlquist, Magnus LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- TRPV1, Capsaicinoids, Vanillin, Vanillylamine, Fatty acids, Acyl-CoA, Capsaicin synthase, Fermentation, Capsicum, Saccharomyces cerevisiae
- in
- Biotechnology Advances
- volume
- 59
- article number
- 107989
- pages
- 12 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85130804308
- pmid:35623491
- ISSN
- 0734-9750
- DOI
- 10.1016/j.biotechadv.2022.107989
- language
- English
- LU publication?
- yes
- id
- ead08f5f-a550-4bd3-8c2a-de9f40ecb4a7
- date added to LUP
- 2022-06-12 18:31:00
- date last changed
- 2022-09-15 03:00:16
@article{ead08f5f-a550-4bd3-8c2a-de9f40ecb4a7,
abstract = {{Capsaicinoids are bioactive alkaloids produced by the chili pepper fruit and are known to be the most potent agonists of the human pain receptor TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). They are currently produced by extraction from chili pepper fruit or by chemical synthesis. Transfer of the biosynthetic route to a microbial host could enable more efficient capsaicinoid production by fermentation and may also enable the use of synthetic biology to create a diversity of new compounds with potentially improved properties. This review summarises the current state of the art on the biosynthesis of capsaicinoid precursors in baker's yeast, <i>Saccharomyces cerevisiae</i>, and discusses bioengineering strategies for achieving total synthesis from sugar.}},
author = {{Muratovska, Nina and Silva, Paulo and Pozdniakova, Tatiana and Pereira, Humberto and Grey, Carl and Johansson, Björn and Carlquist, Magnus}},
issn = {{0734-9750}},
keywords = {{TRPV1; Capsaicinoids; Vanillin; Vanillylamine; Fatty acids; Acyl-CoA; Capsaicin synthase; Fermentation; Capsicum; Saccharomyces cerevisiae}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Biotechnology Advances}},
title = {{Towards engineered yeast as production platform for capsaicinoids}},
url = {{http://dx.doi.org/10.1016/j.biotechadv.2022.107989}},
doi = {{10.1016/j.biotechadv.2022.107989}},
volume = {{59}},
year = {{2022}},
}