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Inflammatory Animal Models of Parkinson's Disease

García-Revilla, Juan LU ; Herrera, Antonio J. ; De Pablos, Rocío M. and Venero, José Luis (2022) In Journal of Parkinson's Disease 12. p.165-182
Abstract

Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models of PD to study the potential contribution of microglia and peripheral immune cells to the degeneration of the nigrostriatal system and help develop potential therapies for PD. In this review, we have summarised the main PD immune models. From a historical perspective, we highlight first the main features of intranigral injections of different pro-inflammogens, including lipopolysaccharide (LPS), thrombin, neuromelanin, etc. The use of adenoviral vectors to promote microglia-specific overexpression of different... (More)

Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models of PD to study the potential contribution of microglia and peripheral immune cells to the degeneration of the nigrostriatal system and help develop potential therapies for PD. In this review, we have summarised the main PD immune models. From a historical perspective, we highlight first the main features of intranigral injections of different pro-inflammogens, including lipopolysaccharide (LPS), thrombin, neuromelanin, etc. The use of adenoviral vectors to promote microglia-specific overexpression of different molecules in the ventral mesencephalon, including -synuclein, IL-1β, and TNF, are also presented and briefly discussed. Finally, we summarise different models associated with peripheral inflammation whose contribution to the pathogenesis of neurodegenerative diseases is now an outstanding question. Illustrative examples included systemic LPS administration and dextran sulfate sodium-induced colitis in rodents.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adenovirus, animal models, dextran sulfate sodium, inflammation, lipopolysaccharide, microglia, Parkinson's disease, substantia nigra, thrombin
in
Journal of Parkinson's Disease
volume
12
pages
165 - 182
publisher
IOS Press
external identifiers
  • scopus:85139536112
  • pmid:35662128
ISSN
1877-7171
DOI
10.3233/JPD-213138
language
English
LU publication?
yes
id
eb50b021-a613-41f9-861e-c78380f51de9
date added to LUP
2022-12-22 13:12:00
date last changed
2024-06-10 05:04:33
@article{eb50b021-a613-41f9-861e-c78380f51de9,
  abstract     = {{<p>Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models of PD to study the potential contribution of microglia and peripheral immune cells to the degeneration of the nigrostriatal system and help develop potential therapies for PD. In this review, we have summarised the main PD immune models. From a historical perspective, we highlight first the main features of intranigral injections of different pro-inflammogens, including lipopolysaccharide (LPS), thrombin, neuromelanin, etc. The use of adenoviral vectors to promote microglia-specific overexpression of different molecules in the ventral mesencephalon, including -synuclein, IL-1β, and TNF, are also presented and briefly discussed. Finally, we summarise different models associated with peripheral inflammation whose contribution to the pathogenesis of neurodegenerative diseases is now an outstanding question. Illustrative examples included systemic LPS administration and dextran sulfate sodium-induced colitis in rodents.</p>}},
  author       = {{García-Revilla, Juan and Herrera, Antonio J. and De Pablos, Rocío M. and Venero, José Luis}},
  issn         = {{1877-7171}},
  keywords     = {{adenovirus; animal models; dextran sulfate sodium; inflammation; lipopolysaccharide; microglia; Parkinson's disease; substantia nigra; thrombin}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{165--182}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Parkinson's Disease}},
  title        = {{Inflammatory Animal Models of Parkinson's Disease}},
  url          = {{http://dx.doi.org/10.3233/JPD-213138}},
  doi          = {{10.3233/JPD-213138}},
  volume       = {{12}},
  year         = {{2022}},
}