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Biliary Excretion of the Vasopressin Analogue DDAVP after Intraduodenal, Intrajugular and Intraportal Administration in the Conscious Pig

Lundin, S. ; Pierzynovski, S. G. LU ; Weström, B. R. LU and Bengtsson, H. ‐I (1991) In Pharmacology & Toxicology 68(3). p.177-180
Abstract

Abstract: The biliary excretion of the vasopressin analogue 1‐deamino‐8‐D‐arginine vasopressin (dDAVP) was determined in the pig after three administration routes, intrajugular venous, intraportal venous and intraduodenal. In all cases the biliary excretion was less than 1% of the administered dose. The plasma/bile concentration ratio was less than 1:1. A significant first‐pass effect was found when the liver was exposed to a high intraportal dose of dDAVP. Possible uptake and degradation/biotransformation was evaluated by incubating [3H]dDAVP with liver tissue slices showing that [3H]dDAVP was rapidly removed from the incubation medium. The following conclusions can be drawn from these experiments: 1) The... (More)

Abstract: The biliary excretion of the vasopressin analogue 1‐deamino‐8‐D‐arginine vasopressin (dDAVP) was determined in the pig after three administration routes, intrajugular venous, intraportal venous and intraduodenal. In all cases the biliary excretion was less than 1% of the administered dose. The plasma/bile concentration ratio was less than 1:1. A significant first‐pass effect was found when the liver was exposed to a high intraportal dose of dDAVP. Possible uptake and degradation/biotransformation was evaluated by incubating [3H]dDAVP with liver tissue slices showing that [3H]dDAVP was rapidly removed from the incubation medium. The following conclusions can be drawn from these experiments: 1) The intestinal mucosa constitutes the major barrier to intestinal absorption of dDAVP. 2) dDAVP is excreted in bile in small amounts. 3) Indirect evidence suggests that the dDAVP molecule is degraded/biotransformed in the liver at its C‐terminus. 1991 Nordic Pharmacological Society

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publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmacology & Toxicology
volume
68
issue
3
pages
4 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:2057448
  • scopus:0026065233
ISSN
0901-9928
DOI
10.1111/j.1600-0773.1991.tb01218.x
language
English
LU publication?
yes
id
eb57fb02-abb6-4b43-97f6-70aae49ecadd
date added to LUP
2024-12-05 15:28:11
date last changed
2025-04-04 15:07:41
@article{eb57fb02-abb6-4b43-97f6-70aae49ecadd,
  abstract     = {{<p>Abstract:  The biliary excretion of the vasopressin analogue 1‐deamino‐8‐D‐arginine vasopressin (dDAVP) was determined in the pig after three administration routes, intrajugular venous, intraportal venous and intraduodenal. In all cases the biliary excretion was less than 1% of the administered dose. The plasma/bile concentration ratio was less than 1:1. A significant first‐pass effect was found when the liver was exposed to a high intraportal dose of dDAVP. Possible uptake and degradation/biotransformation was evaluated by incubating [<sup>3</sup>H]dDAVP with liver tissue slices showing that [<sup>3</sup>H]dDAVP was rapidly removed from the incubation medium. The following conclusions can be drawn from these experiments: 1) The intestinal mucosa constitutes the major barrier to intestinal absorption of dDAVP. 2) dDAVP is excreted in bile in small amounts. 3) Indirect evidence suggests that the dDAVP molecule is degraded/biotransformed in the liver at its C‐terminus. 1991 Nordic Pharmacological Society</p>}},
  author       = {{Lundin, S. and Pierzynovski, S. G. and Weström, B. R. and Bengtsson, H. ‐I}},
  issn         = {{0901-9928}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{177--180}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Pharmacology & Toxicology}},
  title        = {{Biliary Excretion of the Vasopressin Analogue DDAVP after Intraduodenal, Intrajugular and Intraportal Administration in the Conscious Pig}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0773.1991.tb01218.x}},
  doi          = {{10.1111/j.1600-0773.1991.tb01218.x}},
  volume       = {{68}},
  year         = {{1991}},
}