Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

[The effect of aldosterone on the second messenger systems in the rat kidney]

Svitasheva, N G LU ; Logvinenko, N S ; Solenov, E I and Ivanova, L N (1991) In Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova 77(10). p.9-114
Abstract

The effect of aldosterone on the cAMP level, the state of inositol-phosphate pool and the intracellular free Ca2+ activity in the rat kidney, were studied. The cAMP level in the kidney cortex homogenate was not changed after i.p. injection of aldosterone. Reliable changes in the content of inositol-phosphates in the kidney cell suspension was not revealed after aldosterone treatment. A short-term enhancement of the intracellular Ca2+ activity in the isolated distal convoluted and cortical collecting tubules under the influence of aldosterone, was revealed. The participation of the second messenger systems in the realisation of aldosterone effects in kidney and the role of Ca2+ in the mechanism of aldosterone action, are discussed.

Please use this url to cite or link to this publication:
author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aldosterone/pharmacology, Animals, Calcium/physiology, Cyclic AMP/physiology, Inositol Phosphates/physiology, Kidney/drug effects, Kidney Cortex/drug effects, Kidney Tubules, Collecting/drug effects, Kidney Tubules, Distal/drug effects, Male, Rats, Rats, Inbred Strains, Second Messenger Systems/drug effects
in
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova
volume
77
issue
10
pages
9 - 114
publisher
Izdatel'stvo Nauka
external identifiers
  • scopus:0026357647
  • pmid:1666572
ISSN
0015-329X
language
English
LU publication?
no
id
eb5a3fcd-3cb4-430b-bdae-b5e2f91d0b6e
date added to LUP
2020-03-02 09:06:00
date last changed
2024-01-02 06:59:15
@article{eb5a3fcd-3cb4-430b-bdae-b5e2f91d0b6e,
  abstract     = {{<p>The effect of aldosterone on the cAMP level, the state of inositol-phosphate pool and the intracellular free Ca2+ activity in the rat kidney, were studied. The cAMP level in the kidney cortex homogenate was not changed after i.p. injection of aldosterone. Reliable changes in the content of inositol-phosphates in the kidney cell suspension was not revealed after aldosterone treatment. A short-term enhancement of the intracellular Ca2+ activity in the isolated distal convoluted and cortical collecting tubules under the influence of aldosterone, was revealed. The participation of the second messenger systems in the realisation of aldosterone effects in kidney and the role of Ca2+ in the mechanism of aldosterone action, are discussed.</p>}},
  author       = {{Svitasheva, N G and Logvinenko, N S and Solenov, E I and Ivanova, L N}},
  issn         = {{0015-329X}},
  keywords     = {{Aldosterone/pharmacology; Animals; Calcium/physiology; Cyclic AMP/physiology; Inositol Phosphates/physiology; Kidney/drug effects; Kidney Cortex/drug effects; Kidney Tubules, Collecting/drug effects; Kidney Tubules, Distal/drug effects; Male; Rats; Rats, Inbred Strains; Second Messenger Systems/drug effects}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{9--114}},
  publisher    = {{Izdatel'stvo Nauka}},
  series       = {{Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova}},
  title        = {{[The effect of aldosterone on the second messenger systems in the rat kidney]}},
  volume       = {{77}},
  year         = {{1991}},
}