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Tumor extension in high-grade gliomas assessed with diffusion magnetic resonance imaging: values and lesion-to-brain ratios of apparent diffusion coefficient and fractional anisotropy.

van Westen, Danielle LU ; Lätt, Jimmy LU ; Englund, Elisabet LU ; Brockstedt, Sara LU and Larsson, Elna-Marie LU (2006) In Acta Radiologica 47(3). p.311-319
Abstract
Purpose: To determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema in gliomas from pure edema in meningiomas and metastases.



Material and Methods: Thirty patients were studied: 18 WHO grade III or IV gliomas, 7 meningiomas, and 5 metastatic lesions. ADC and FA were determined from ROIs placed in peritumoral areas with T2-signal changes, adjacent normal appearing white matter (NAWM), and corresponding areas in the contralateral healthy brain. Values and lesion-to-brain ratios from gliomas were compared to those from meningiomas and metastases.



Results: Values and lesion-to-brain ratios of ADC and FA in peritumoral areas with... (More)
Purpose: To determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema in gliomas from pure edema in meningiomas and metastases.



Material and Methods: Thirty patients were studied: 18 WHO grade III or IV gliomas, 7 meningiomas, and 5 metastatic lesions. ADC and FA were determined from ROIs placed in peritumoral areas with T2-signal changes, adjacent normal appearing white matter (NAWM), and corresponding areas in the contralateral healthy brain. Values and lesion-to-brain ratios from gliomas were compared to those from meningiomas and metastases.



Results: Values and lesion-to-brain ratios of ADC and FA in peritumoral areas with T2-signal changes did not differ between gliomas, meningiomas, and metastases (P = 0.40, P = 0.40, P = 0.61, P = 0.34). Values of ADC and FA and the lesion-to-brain ratio of FA in the adjacent NAWM did not differ between tumor types (P = 0.74, P = 0.25, and P = 0.31). The lesion-to-brain ratio of ADC in the adjacent NAWM was higher in gliomas than in meningiomas and metastases (P = 0.004), but overlapped between tumor types.



Conclusion: Values and lesion-to-brain ratios of ADC and FA in areas with T2-signal changes surrounding intracranial tumors and adjacent NAWM were not helpful for distinguishing pure edema from tumor-infiltrated edema when data from gliomas, meningiomas, and metastases were compared. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain tumors, diffusion weighted imaging, diffusion tensor imaging, magnetic resonance imaging
in
Acta Radiologica
volume
47
issue
3
pages
311 - 319
publisher
John Wiley & Sons
external identifiers
  • wos:000236669600015
  • pmid:16613314
  • scopus:33646244250
ISSN
1600-0455
DOI
10.1080/02841850500539058
language
English
LU publication?
yes
id
eb61d60a-e6cc-4c94-8d3f-c8b71ec1c617 (old id 155912)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16613314&dopt=Abstract
date added to LUP
2007-07-24 13:25:53
date last changed
2019-07-02 03:04:43
@article{eb61d60a-e6cc-4c94-8d3f-c8b71ec1c617,
  abstract     = {Purpose: To determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema in gliomas from pure edema in meningiomas and metastases.<br/><br>
<br/><br>
Material and Methods: Thirty patients were studied: 18 WHO grade III or IV gliomas, 7 meningiomas, and 5 metastatic lesions. ADC and FA were determined from ROIs placed in peritumoral areas with T2-signal changes, adjacent normal appearing white matter (NAWM), and corresponding areas in the contralateral healthy brain. Values and lesion-to-brain ratios from gliomas were compared to those from meningiomas and metastases.<br/><br>
<br/><br>
Results: Values and lesion-to-brain ratios of ADC and FA in peritumoral areas with T2-signal changes did not differ between gliomas, meningiomas, and metastases (P = 0.40, P = 0.40, P = 0.61, P = 0.34). Values of ADC and FA and the lesion-to-brain ratio of FA in the adjacent NAWM did not differ between tumor types (P = 0.74, P = 0.25, and P = 0.31). The lesion-to-brain ratio of ADC in the adjacent NAWM was higher in gliomas than in meningiomas and metastases (P = 0.004), but overlapped between tumor types.<br/><br>
<br/><br>
Conclusion: Values and lesion-to-brain ratios of ADC and FA in areas with T2-signal changes surrounding intracranial tumors and adjacent NAWM were not helpful for distinguishing pure edema from tumor-infiltrated edema when data from gliomas, meningiomas, and metastases were compared.},
  author       = {van Westen, Danielle and Lätt, Jimmy and Englund, Elisabet and Brockstedt, Sara and Larsson, Elna-Marie},
  issn         = {1600-0455},
  keyword      = {Brain tumors,diffusion weighted imaging,diffusion tensor imaging,magnetic resonance imaging},
  language     = {eng},
  number       = {3},
  pages        = {311--319},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Tumor extension in high-grade gliomas assessed with diffusion magnetic resonance imaging: values and lesion-to-brain ratios of apparent diffusion coefficient and fractional anisotropy.},
  url          = {http://dx.doi.org/10.1080/02841850500539058},
  volume       = {47},
  year         = {2006},
}