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Long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in 15 European cohorts within the ESCAPE project

Andersen, Zorana J.; Stafoggia, Massimo; Weinmayr, Gudrun; Pedersen, Marie; Galassi, Claudia; Jørgensen, Jeanette T.; Oudin, Anna LU ; Forsberg, Bertil; Olsson, David and Oftedal, Bente, et al. (2017) In Environmental Health Perspectives 125(10).
Abstract

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2:5 μm, ≤10 μm, and 2:5–10 μm in diameter... (More)

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2:5 μm, ≤10 μm, and 2:5–10 μm in diameter (PM2:5, PM10, and PMcoarse, respectively); PM2:5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses. RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2:5 {hazard ratio (HR) =1:08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m3 }, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m3 ], PMcoarse [1.20 (95% CI: 0.96, 1.49 per 5 μg/m3 ], and NO2 [1.02 (95% CI: 0.98, 1.07 per 10 μg/m3 ], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m3, p =0:04]. CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.

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Environmental Health Perspectives
volume
125
issue
10
publisher
National Institute of Environmental Health Science
external identifiers
  • scopus:85032889270
ISSN
0091-6765
DOI
10.1289/EHP1742
language
English
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no
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eb7be1ee-0f78-4410-acda-86a6de40df0e
date added to LUP
2018-02-13 10:42:25
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2018-09-02 04:44:54
@article{eb7be1ee-0f78-4410-acda-86a6de40df0e,
  abstract     = {<p>BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women. METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2:5 μm, ≤10 μm, and 2:5–10 μm in diameter (PM<sub>2:5</sub>, PM<sub>10</sub>, and PM<sub>coarse</sub>, respectively); PM<sub>2:5</sub> absorbance; nitrogen oxides (NO<sub>2</sub> and NO<sub>x</sub>); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses. R<sub>ESULTS</sub>: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM<sub>2:5</sub> {hazard ratio (HR) =1:08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m<sup>3</sup> }, PM<sub>10</sub> [1.07 (95% CI: 0.89, 1.30) per 10 μg/m<sup>3</sup> ], PM<sub>coarse</sub> [1.20 (95% CI: 0.96, 1.49 per 5 μg/m<sup>3</sup> ], and NO<sub>2</sub> [1.02 (95% CI: 0.98, 1.07 per 10 μg/m<sup>3</sup> ], and a statistically significant association with NO<sub>x</sub> [1.04 (95% CI: 1.00, 1.08) per 20 μg/m<sup>3</sup>, p =0:04]. CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.</p>},
  articleno    = {107005},
  author       = {Andersen, Zorana J. and Stafoggia, Massimo and Weinmayr, Gudrun and Pedersen, Marie and Galassi, Claudia and Jørgensen, Jeanette T. and Oudin, Anna and Forsberg, Bertil and Olsson, David and Oftedal, Bente and Aasvang, Gunn Marit and Aamodt, Geir and Pyko, Andrei and Pershagen, Göran and Korek, Michal and de Faire, Ulf and Pedersen, Nancy L. and Östenson, Claes Göran and Fratiglioni, Laura and Eriksen, Kirsten T. and Tjønneland, Anne and Peeters, Petra H. and Bueno-De-Mesquita, Bas and Plusquin, Michelle and Key, Timothy J. and Jaensch, Andrea and Nagel, Gabriele and Lang, Alois and Wang, Meng and Tsai, Ming Yi and Fournier, Agnes and Boutron-Ruault, Marie Christine and Baglietto, Laura and Grioni, Sara and Marcon, Alessandro and Krogh, Vittorio and Ricceri, Fulvio and Sacerdote, Carlotta and Migliore, Enrica and Tamayo-Uria, Ibon and Amiano, Pilar and Dorronsoro, Miren and Vermeulen, Roel and Sokhi, Ranjeet and Keuken, Menno and de Hoogh, Kees and Beelen, Rob and Vineis, Paolo and Cesaroni, Giulia and Brunekreef, Bert and Hoek, Gerard and Raaschou-Nielsen, Ole},
  issn         = {0091-6765},
  language     = {eng},
  month        = {10},
  number       = {10},
  publisher    = {National Institute of Environmental Health Science},
  series       = {Environmental Health Perspectives},
  title        = {Long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in 15 European cohorts within the ESCAPE project},
  url          = {http://dx.doi.org/10.1289/EHP1742},
  volume       = {125},
  year         = {2017},
}