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The interplay and influence of anxiety and depression among men with early-stage prostate cancer and their close allies

Majumdar, Jennifer R. ; Flaherty, Kathleen R. ; Schofield, Elizabeth ; Carlsson, Sigrid V. LU ; Shaffer, Kelly M. ; Ehdaie, Behfar ; Diefenbach, Michael A. and Nelson, Christian J. (2025) In Supportive Care in Cancer 33(12).
Abstract

Purpose: The purpose of this study was to explore the interplay and influence of anxiety and depression between patients with low-risk localized prostate cancer on active surveillance (AS) and their close allies. The research sought to determine if emotional states are interdependent within these dyads, hypothesizing that both actor (self) and partner (close ally) effects would be significant. Methods: This secondary analysis used data from a mixed-methods study involving patients and their close allies at Memorial Sloan Kettering Cancer Center. Participants completed the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) and the Profile of Mood States (POMS) to assess anxiety and depression at baseline and 6 months. The Actor-Partner... (More)

Purpose: The purpose of this study was to explore the interplay and influence of anxiety and depression between patients with low-risk localized prostate cancer on active surveillance (AS) and their close allies. The research sought to determine if emotional states are interdependent within these dyads, hypothesizing that both actor (self) and partner (close ally) effects would be significant. Methods: This secondary analysis used data from a mixed-methods study involving patients and their close allies at Memorial Sloan Kettering Cancer Center. Participants completed the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) and the Profile of Mood States (POMS) to assess anxiety and depression at baseline and 6 months. The Actor-Partner Interdependence Model (APIM) was employed to evaluate actor and partner effects for both outcomes. Results: The study included 106 patients and their close allies, with 92% of patients being male and 82% of allies being spouses. Anxiety and depression scores at baseline were correlated between patients and allies (r = 0.40 and r = 0.29, respectively). However, APIM analysis revealed significant actor effects for anxiety and depression (p < 0.05) but no partner effects, indicating that individuals’ baseline emotions influenced their own 6-month outcomes, without crossover influence from their partners. Conclusions: While baseline anxiety and depression were related within patient-ally dyads, there was no evidence of interdependence over time. This suggests that individual emotional states are more predictive of future well-being than partner influence, highlighting the need for personalized psychological interventions during AS.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Active surveillance, Anxiety, Depression, Partners, Prostate, Psycho-oncology, Surgery
in
Supportive Care in Cancer
volume
33
issue
12
article number
1032
publisher
Springer Science and Business Media B.V.
external identifiers
  • scopus:105021068178
  • pmid:41205128
ISSN
0941-4355
DOI
10.1007/s00520-025-10111-w
language
English
LU publication?
yes
id
eb82b1b7-329a-4a49-8c91-31088cae0cb0
date added to LUP
2025-12-08 15:14:45
date last changed
2025-12-08 15:15:36
@article{eb82b1b7-329a-4a49-8c91-31088cae0cb0,
  abstract     = {{<p>Purpose: The purpose of this study was to explore the interplay and influence of anxiety and depression between patients with low-risk localized prostate cancer on active surveillance (AS) and their close allies. The research sought to determine if emotional states are interdependent within these dyads, hypothesizing that both actor (self) and partner (close ally) effects would be significant. Methods: This secondary analysis used data from a mixed-methods study involving patients and their close allies at Memorial Sloan Kettering Cancer Center. Participants completed the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) and the Profile of Mood States (POMS) to assess anxiety and depression at baseline and 6 months. The Actor-Partner Interdependence Model (APIM) was employed to evaluate actor and partner effects for both outcomes. Results: The study included 106 patients and their close allies, with 92% of patients being male and 82% of allies being spouses. Anxiety and depression scores at baseline were correlated between patients and allies (r = 0.40 and r = 0.29, respectively). However, APIM analysis revealed significant actor effects for anxiety and depression (p &lt; 0.05) but no partner effects, indicating that individuals’ baseline emotions influenced their own 6-month outcomes, without crossover influence from their partners. Conclusions: While baseline anxiety and depression were related within patient-ally dyads, there was no evidence of interdependence over time. This suggests that individual emotional states are more predictive of future well-being than partner influence, highlighting the need for personalized psychological interventions during AS.</p>}},
  author       = {{Majumdar, Jennifer R. and Flaherty, Kathleen R. and Schofield, Elizabeth and Carlsson, Sigrid V. and Shaffer, Kelly M. and Ehdaie, Behfar and Diefenbach, Michael A. and Nelson, Christian J.}},
  issn         = {{0941-4355}},
  keywords     = {{Active surveillance; Anxiety; Depression; Partners; Prostate; Psycho-oncology; Surgery}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{Supportive Care in Cancer}},
  title        = {{The interplay and influence of anxiety and depression among men with early-stage prostate cancer and their close allies}},
  url          = {{http://dx.doi.org/10.1007/s00520-025-10111-w}},
  doi          = {{10.1007/s00520-025-10111-w}},
  volume       = {{33}},
  year         = {{2025}},
}