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Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors

Stocks, Tanja LU ; Taylor, Moira A. ; Ängquist, Lars ; Macdonald, Ian A. ; Arner, Peter ; Holst, Claus ; Oppert, Jean Michel ; Martinez, J. Alfredo ; Rössner, Stephan and Polak, Jan , et al. (2013) In Obesity Facts 6(3). p.217-227
Abstract

Objective: To investigate in a secondary analysis of a randomised trial the effects of a low-/high-fat diet and reported change from baseline in energy% from protein (prot%), in relation to changes in body size and metabolic factors. Methods: Obese adults (n = 771) were randomised to a 600 kcal energy-deficient low-fat (20-25 fat%) or high-fat (40-45 fat%) diet over 10 weeks. Dietary intake data at baseline and during the intervention were available in 585 completers. We used linear regression to calculate the combined effects of randomised group and groups of prot% change (<-2 /-2 to 2/>2) on outcomes. Results: The low-fat group with >2 prot% increase lost 1.1 kg more weight (p = 0.03) and reduced cholesterol by 0.25 mmol/l... (More)

Objective: To investigate in a secondary analysis of a randomised trial the effects of a low-/high-fat diet and reported change from baseline in energy% from protein (prot%), in relation to changes in body size and metabolic factors. Methods: Obese adults (n = 771) were randomised to a 600 kcal energy-deficient low-fat (20-25 fat%) or high-fat (40-45 fat%) diet over 10 weeks. Dietary intake data at baseline and during the intervention were available in 585 completers. We used linear regression to calculate the combined effects of randomised group and groups of prot% change (<-2 /-2 to 2/>2) on outcomes. Results: The low-fat group with >2 prot% increase lost 1.1 kg more weight (p = 0.03) and reduced cholesterol by 0.25 mmol/l more (p = 0.003) than the high-fat group with >2 prot% decrease. These differences were 2.5-fold and 1.8-fold greater than the differences between the low-fat and high-fat groups while not considering prot% change. The high-fat group reduced plasma triglycerides more than the low-fat group, but not compared to those in the low-fat group with >2 units prot% increase (p fat-protein interaction = 0.01). Conclusions: Under energy restriction, participants on a low-fat diet who had increased the percentage energy intake from protein showed the greatest reduction in weight and cholesterol, and a triglyceride reduction equally large to that of participants on a high-fat diet.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood glucose, Dietary fats, Dietary proteins, Lipids, Obesity
in
Obesity Facts
volume
6
issue
3
pages
217 - 227
publisher
Karger
external identifiers
  • pmid:23711745
  • scopus:84880087632
ISSN
1662-4025
DOI
10.1159/000351726
language
English
LU publication?
no
id
eb849484-3fb5-4b79-910b-7a839e2dc5b0
date added to LUP
2019-05-31 08:52:47
date last changed
2020-01-13 01:56:51
@article{eb849484-3fb5-4b79-910b-7a839e2dc5b0,
  abstract     = {<p>Objective: To investigate in a secondary analysis of a randomised trial the effects of a low-/high-fat diet and reported change from baseline in energy% from protein (prot%), in relation to changes in body size and metabolic factors. Methods: Obese adults (n = 771) were randomised to a 600 kcal energy-deficient low-fat (20-25 fat%) or high-fat (40-45 fat%) diet over 10 weeks. Dietary intake data at baseline and during the intervention were available in 585 completers. We used linear regression to calculate the combined effects of randomised group and groups of prot% change (&lt;-2 /-2 to 2/&gt;2) on outcomes. Results: The low-fat group with &gt;2 prot% increase lost 1.1 kg more weight (p = 0.03) and reduced cholesterol by 0.25 mmol/l more (p = 0.003) than the high-fat group with &gt;2 prot% decrease. These differences were 2.5-fold and 1.8-fold greater than the differences between the low-fat and high-fat groups while not considering prot% change. The high-fat group reduced plasma triglycerides more than the low-fat group, but not compared to those in the low-fat group with &gt;2 units prot% increase (p fat-protein interaction = 0.01). Conclusions: Under energy restriction, participants on a low-fat diet who had increased the percentage energy intake from protein showed the greatest reduction in weight and cholesterol, and a triglyceride reduction equally large to that of participants on a high-fat diet.</p>},
  author       = {Stocks, Tanja and Taylor, Moira A. and Ängquist, Lars and Macdonald, Ian A. and Arner, Peter and Holst, Claus and Oppert, Jean Michel and Martinez, J. Alfredo and Rössner, Stephan and Polak, Jan and Langin, Dominique and Saris, Wim H.M. and Astrup, Arne and Sørensen, Thorkild I.A.},
  issn         = {1662-4025},
  language     = {eng},
  month        = {06},
  number       = {3},
  pages        = {217--227},
  publisher    = {Karger},
  series       = {Obesity Facts},
  title        = {Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors},
  url          = {http://dx.doi.org/10.1159/000351726},
  doi          = {10.1159/000351726},
  volume       = {6},
  year         = {2013},
}