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Generation of hexahydrophthalic anhydride atmospheres in a controlled human-use test chamber

Jönsson, Bo A LU ; Welinder, Hans LU and Skarping, Gunnar LU (1994) In American Industrial Hygiene Association Journal 55(4). p.330-338
Abstract
A method for generating controlled atmospheres of hexahydrophthalic anhydride (HHPA) in an 8 m3 exposure chamber was developed. The permeation principle was used for gaseous HHPA generation. HHPA concentration was monitored by sampling on XAD-2 tubes and by a Fourier-transform infrared (FTIR) spectrometer using the partial least-square quantitative method. The repeatability of the FTIR was 5%, the reproducibility 12%, and the limit of detection 10 micrograms/m3. A bubbler method determined the sum of HHPA and HHP acid by using gas chromatography/mass spectrometry detection after derivatization with methanol/boron trifluoride. The precision of the work-up procedure was 3% and the recovery was 94% at 300 ng sampled amount of HHPA. The limit... (More)
A method for generating controlled atmospheres of hexahydrophthalic anhydride (HHPA) in an 8 m3 exposure chamber was developed. The permeation principle was used for gaseous HHPA generation. HHPA concentration was monitored by sampling on XAD-2 tubes and by a Fourier-transform infrared (FTIR) spectrometer using the partial least-square quantitative method. The repeatability of the FTIR was 5%, the reproducibility 12%, and the limit of detection 10 micrograms/m3. A bubbler method determined the sum of HHPA and HHP acid by using gas chromatography/mass spectrometry detection after derivatization with methanol/boron trifluoride. The precision of the work-up procedure was 3% and the recovery was 94% at 300 ng sampled amount of HHPA. The limit of detection was 10 ng HHPA. The variation in the permeation rate was 3% over 3 days. Different concentrations in the exposure chamber were generated by changing the temperature of the permeation tubes. The generated HHPA concentration range, at human exposure, was 3-90 micrograms/m3. The concentration at one temperature was reproducible even after major changes in the temperature. The coefficient of variation (CV) of six samples from different places in the breathing zone was 3%. The variation in the concentration, during an 8-hour human exposure at 10 micrograms/m3, was 3%. Time-weighted averages (8 hour) for human exposures of 10 micrograms/m3 (CV = 15%; n = 6); 37 micrograms/m3 (CV = 5%; n = 5); and 81 micrograms/m3 (CV = 6%; n = 9) were obtained at intended concentrations of 10 micrograms/m3, 40 micrograms/m3, and 80 micrograms/m3. The loss of HHPA in the exposure chamber was 54% (CV = 17%).(ABSTRACT TRUNCATED AT 250 WORDS) (Less)
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Contribution to journal
publication status
published
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in
American Industrial Hygiene Association Journal
volume
55
issue
4
pages
330 - 338
publisher
Taylor & Francis
external identifiers
  • pmid:8209838
  • scopus:0028226870
ISSN
1542-8117
DOI
10.1080/15428119491018970
language
English
LU publication?
yes
id
eb8f3b95-ceae-4897-8fd5-533a99c43914 (old id 1107881)
date added to LUP
2016-04-01 17:12:29
date last changed
2025-10-14 11:42:27
@article{eb8f3b95-ceae-4897-8fd5-533a99c43914,
  abstract     = {{A method for generating controlled atmospheres of hexahydrophthalic anhydride (HHPA) in an 8 m3 exposure chamber was developed. The permeation principle was used for gaseous HHPA generation. HHPA concentration was monitored by sampling on XAD-2 tubes and by a Fourier-transform infrared (FTIR) spectrometer using the partial least-square quantitative method. The repeatability of the FTIR was 5%, the reproducibility 12%, and the limit of detection 10 micrograms/m3. A bubbler method determined the sum of HHPA and HHP acid by using gas chromatography/mass spectrometry detection after derivatization with methanol/boron trifluoride. The precision of the work-up procedure was 3% and the recovery was 94% at 300 ng sampled amount of HHPA. The limit of detection was 10 ng HHPA. The variation in the permeation rate was 3% over 3 days. Different concentrations in the exposure chamber were generated by changing the temperature of the permeation tubes. The generated HHPA concentration range, at human exposure, was 3-90 micrograms/m3. The concentration at one temperature was reproducible even after major changes in the temperature. The coefficient of variation (CV) of six samples from different places in the breathing zone was 3%. The variation in the concentration, during an 8-hour human exposure at 10 micrograms/m3, was 3%. Time-weighted averages (8 hour) for human exposures of 10 micrograms/m3 (CV = 15%; n = 6); 37 micrograms/m3 (CV = 5%; n = 5); and 81 micrograms/m3 (CV = 6%; n = 9) were obtained at intended concentrations of 10 micrograms/m3, 40 micrograms/m3, and 80 micrograms/m3. The loss of HHPA in the exposure chamber was 54% (CV = 17%).(ABSTRACT TRUNCATED AT 250 WORDS)}},
  author       = {{Jönsson, Bo A and Welinder, Hans and Skarping, Gunnar}},
  issn         = {{1542-8117}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{330--338}},
  publisher    = {{Taylor & Francis}},
  series       = {{American Industrial Hygiene Association Journal}},
  title        = {{Generation of hexahydrophthalic anhydride atmospheres in a controlled human-use test chamber}},
  url          = {{http://dx.doi.org/10.1080/15428119491018970}},
  doi          = {{10.1080/15428119491018970}},
  volume       = {{55}},
  year         = {{1994}},
}