Chronotropic Incompetence in Parkinson's Disease : A Possible Marker of Severe Disease Phenotype?
Andréasson, Mattias LU ; Nickander, Jannike ; Ståhlberg, Marcus ; Fedorowski, Artur LU
and Svenningsson, Per
LU
(2024)
In Journal of Parkinson's Disease
- Abstract
Autonomic dysfunction is a prevalent feature of Parkinson's disease (PD), mediated by disease involvement of the autonomic nervous system. Chronotropic incompetence (CI) refers to inadequate increase of heart rate in response to elevated metabolic demand, partly dependent on postganglionic sympathetic tone. In a retrospective study, PD patients with/without CI were identified. We show that PD with CI was associated with a higher levodopa equivalent daily dose and Hoehn and Yahr stage, 5±2 years after motor onset. Our data support a putative role of CI as a clinical marker of a more severe disease phenotype, possibly reflecting more widespread alpha-synuclein pathology.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ebaf07c5-1a3d-463a-ad20-29ee896bf8b7
- author
- Andréasson, Mattias
LU
; Nickander, Jannike
; Ståhlberg, Marcus
; Fedorowski, Artur
LU
and Svenningsson, Per
LU
- publishing date
- 2024-03-20
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- Parkinson’s disease, autonomic nervous system diseases, postganglionic autonomic fibers, exercise test
- in
- Journal of Parkinson's Disease
- pages
- 7 pages
- publisher
- IOS Press
- external identifiers
-
- pmid:38517804
- ISSN
- 1877-718X
- DOI
- 10.3233/JPD-230256
- language
- English
- LU publication?
- no
- id
- ebaf07c5-1a3d-463a-ad20-29ee896bf8b7
- date added to LUP
- 2024-03-25 23:05:26
- date last changed
- 2024-03-26 08:11:53
@article{ebaf07c5-1a3d-463a-ad20-29ee896bf8b7,
abstract = {{<p>Autonomic dysfunction is a prevalent feature of Parkinson's disease (PD), mediated by disease involvement of the autonomic nervous system. Chronotropic incompetence (CI) refers to inadequate increase of heart rate in response to elevated metabolic demand, partly dependent on postganglionic sympathetic tone. In a retrospective study, PD patients with/without CI were identified. We show that PD with CI was associated with a higher levodopa equivalent daily dose and Hoehn and Yahr stage, 5±2 years after motor onset. Our data support a putative role of CI as a clinical marker of a more severe disease phenotype, possibly reflecting more widespread alpha-synuclein pathology.</p>}},
author = {{Andréasson, Mattias and Nickander, Jannike and Ståhlberg, Marcus and Fedorowski, Artur and Svenningsson, Per}},
issn = {{1877-718X}},
keywords = {{Parkinson’s disease; autonomic nervous system diseases; postganglionic autonomic fibers; exercise test}},
language = {{eng}},
month = {{03}},
publisher = {{IOS Press}},
series = {{Journal of Parkinson's Disease}},
title = {{Chronotropic Incompetence in Parkinson's Disease : A Possible Marker of Severe Disease Phenotype?}},
url = {{http://dx.doi.org/10.3233/JPD-230256}},
doi = {{10.3233/JPD-230256}},
year = {{2024}},
}