Advanced

The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)

Sawada, Norie; Wark, Petra A.; Merritt, Melissa A; Tsugane, Shoichiro; Ward, Heather A.; Rinaldi, Sabina; Weiderpass, Elisabete; Dartois, Laureen; His, Mathilde and Boutron-Ruault, Marie-Christine, et al. (2017) In PLoS ONE 12(3).
Abstract

Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority... (More)

Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: Q5.svQ1 = 1.11, 95%CI = 1.00-1.24; women: Q5.svQ1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: Q5.svQ1 = 0.63, 95%CI = 0.56-0.71; women: vs.1Q= 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: Q5.svQ1 = 0.64, 95%CI = 0.55-0.75; women: vs.1Q= 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: Q5.svQ1 = 0.45, 95%CI = 0.28-0.71; women: vs.1Q= 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
keywords
cancer , Nutrition, mortality, attained height , sitting height
in
PLoS ONE
volume
12
issue
3
publisher
Public Library of Science
external identifiers
  • scopus:85014548956
  • wos:000396021100059
ISSN
1932-6203
DOI
10.1371/journal.pone.0173117
language
English
LU publication?
yes
id
ebf50aab-c58d-40d4-aaa9-56503a048e69
date added to LUP
2017-03-17 13:06:47
date last changed
2019-04-10 03:39:26
@article{ebf50aab-c58d-40d4-aaa9-56503a048e69,
  abstract     = {<p>Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: Q5.svQ1 = 1.11, 95%CI = 1.00-1.24; women: Q5.svQ1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: Q5.svQ1 = 0.63, 95%CI = 0.56-0.71; women: vs.1Q= 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: Q5.svQ1 = 0.64, 95%CI = 0.55-0.75; women: vs.1Q= 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: Q5.svQ1 = 0.45, 95%CI = 0.28-0.71; women: vs.1Q= 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.</p>},
  articleno    = {e0173117},
  author       = {Sawada, Norie and Wark, Petra A. and Merritt, Melissa A and Tsugane, Shoichiro and Ward, Heather A. and Rinaldi, Sabina and Weiderpass, Elisabete and Dartois, Laureen and His, Mathilde and Boutron-Ruault, Marie-Christine and Turzanski-Fortner, Renée and Kaaks, Rudolf and Overvad, Kim and Redondo, María Luisa and Travier, Noemie and Molina-Portillo, Elena and Dorronsoro, Miren and Cirera, Lluis and Ardanaz, Eva and Perez-Cornago, Aurora and Trichopoulou, Antonia and Lagiou, Pagona and Valanou, Elissavet and Masala, Giovanna and Pala, Valeria and Peeters, Petra H. M. and van der Schouw, Yvonne T. and Melander, Olle and Manjer, Jonas and Silva, Marisa Da and Skeie, Guri and Tjønneland, Anne and Olsen, Anja and Gunter, Marc J. and Riboli, Elio and Cross, Amanda J},
  issn         = {1932-6203},
  keyword      = {cancer ,Nutrition,mortality,attained  height ,sitting height},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1371/journal.pone.0173117},
  volume       = {12},
  year         = {2017},
}