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Prevalence of IgA-antiendomysium and IgA-antigliadin autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children and adolescents

Carlsson, Annelie LU orcid ; Axelsson, Irene E. M. LU ; Borulf, Stefan K. LU ; Bredberg, Anders C. A. LU ; Lindberg, Bengt A. LU ; Sjöberg, Klas G. LU orcid and Ivarsson, Sten-A. LU (1999) In Pediatrics 103(6 I). p.1248-1252
Abstract
Objective. This study was conducted to investigate the prevalence of celiac disease (CD) in children and adolescents at diagnosis of insulin- dependent diabetes mellitus (IDDM) before insulin treatment was started. Material and Methods. At diagnosis of IDDM, and before treatment was started, 115 children and adolescents were screened for IgA-antiendomysium (EMA) and IgA-antigliadin antibodies (AGA). Those found to be EMA-positive and/or AGA- positive were investigated further with intestinal biopsy. Results. Of the 115 patients, 2 had known CD at diagnosis of IDDM; of the remainder of patients, 6% (7/113) were found to be EMA-positive and 9% (10/113) were found to have AGA levels above normal. Of the 6 patients who underwent biopsy, 5... (More)
Objective. This study was conducted to investigate the prevalence of celiac disease (CD) in children and adolescents at diagnosis of insulin- dependent diabetes mellitus (IDDM) before insulin treatment was started. Material and Methods. At diagnosis of IDDM, and before treatment was started, 115 children and adolescents were screened for IgA-antiendomysium (EMA) and IgA-antigliadin antibodies (AGA). Those found to be EMA-positive and/or AGA- positive were investigated further with intestinal biopsy. Results. Of the 115 patients, 2 had known CD at diagnosis of IDDM; of the remainder of patients, 6% (7/113) were found to be EMA-positive and 9% (10/113) were found to have AGA levels above normal. Of the 6 patients who underwent biopsy, 5 manifested villous atrophy. In addition, 2 patients with high EMA and AGA antibody titers refused biopsy, and 4 patients with low EMA and/or AGA titers were found to have normal titers at control before biopsy decision. Conclusion. Because the prevalence of CD at diagnosis of IDDM would seem to be 6% to 8%, screening for CD seems to be justified among patients with newly diagnosed IDDM. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Celiac disease, IgA-antiendomysium antibodies, IgA-antigliadin antibodies, Insulin-dependent diabetes mellitus, autoantibody, gliadin antibody, immunoglobulin A antibody, adolescent, allele, antibody specificity, antibody titer, article, celiac disease, child, female, human, immune system, immunoregulation, insulin dependent diabetes mellitus, insulin treatment, major clinical study, male, priority journal
in
Pediatrics
volume
103
issue
6 I
pages
5 pages
publisher
American Academy of Pediatrics
external identifiers
  • scopus:0033035612
ISSN
1098-4275
DOI
10.1542/peds.103.6.1248
language
English
LU publication?
yes
id
ebf98a47-dd27-43c5-9ed5-9331954be5df
date added to LUP
2017-11-08 14:06:00
date last changed
2025-10-14 13:27:28
@article{ebf98a47-dd27-43c5-9ed5-9331954be5df,
  abstract     = {{Objective. This study was conducted to investigate the prevalence of celiac disease (CD) in children and adolescents at diagnosis of insulin- dependent diabetes mellitus (IDDM) before insulin treatment was started. Material and Methods. At diagnosis of IDDM, and before treatment was started, 115 children and adolescents were screened for IgA-antiendomysium (EMA) and IgA-antigliadin antibodies (AGA). Those found to be EMA-positive and/or AGA- positive were investigated further with intestinal biopsy. Results. Of the 115 patients, 2 had known CD at diagnosis of IDDM; of the remainder of patients, 6% (7/113) were found to be EMA-positive and 9% (10/113) were found to have AGA levels above normal. Of the 6 patients who underwent biopsy, 5 manifested villous atrophy. In addition, 2 patients with high EMA and AGA antibody titers refused biopsy, and 4 patients with low EMA and/or AGA titers were found to have normal titers at control before biopsy decision. Conclusion. Because the prevalence of CD at diagnosis of IDDM would seem to be 6% to 8%, screening for CD seems to be justified among patients with newly diagnosed IDDM.}},
  author       = {{Carlsson, Annelie and Axelsson, Irene E. M. and Borulf, Stefan K. and Bredberg, Anders C. A. and Lindberg, Bengt A. and Sjöberg, Klas G. and Ivarsson, Sten-A.}},
  issn         = {{1098-4275}},
  keywords     = {{Celiac disease; IgA-antiendomysium antibodies; IgA-antigliadin antibodies; Insulin-dependent diabetes mellitus; autoantibody; gliadin antibody; immunoglobulin A antibody; adolescent; allele; antibody specificity; antibody titer; article; celiac disease; child; female; human; immune system; immunoregulation; insulin dependent diabetes mellitus; insulin treatment; major clinical study; male; priority journal}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6 I}},
  pages        = {{1248--1252}},
  publisher    = {{American Academy of Pediatrics}},
  series       = {{Pediatrics}},
  title        = {{Prevalence of IgA-antiendomysium and IgA-antigliadin autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children and adolescents}},
  url          = {{http://dx.doi.org/10.1542/peds.103.6.1248}},
  doi          = {{10.1542/peds.103.6.1248}},
  volume       = {{103}},
  year         = {{1999}},
}