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Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function : An experimental study in healthy children and adults

Rissler, Jenny LU ; Gudmundsson, Anders LU ; Nicklasson, Hanna LU ; Swietlicki, Erik LU ; Wollmer, Per LU and Löndahl, Jakob LU (2017) In Particle and Fibre Toxicology 14(1).
Abstract

Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. Method: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged... (More)

Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. Method: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged 7-70 years. A comprehensive examination of lung function was performed for all subjects. Principal component analyses and multiple regression analyses were used to explore the relationships between subject characteristics and particle deposition. Results: A large individual variability in respiratory tract deposition efficiency was found. Individuals with high deposition of a certain particle size generally had high deposition for all particles <3500 nm. The individual variability was explained by two factors: breathing pattern, and lung structural and functional properties. The most important predictors were found to be breathing frequency and anatomical airway dead space. We also present a linear regression model describing the deposition based on four variables: tidal volume, breathing frequency, anatomical dead space and resistance of the respiratory system (the latter measured with impulse oscillometry). Conclusions: To understand why some individuals are more susceptible to airborne particles we must understand, and take into account, the individual variability in the probability of particles to deposit in the respiratory tract by considering not only breathing patterns but also adequate measures of relevant structural and functional properties.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aerosols, Airborne particles, Airway dead space, Individual variability, Inhalation, Lung dose, NanoSafety, Particle lung deposition, Respiratory tract deposition
in
Particle and Fibre Toxicology
volume
14
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85018416270
  • wos:000398513900001
ISSN
1743-8977
DOI
10.1186/s12989-017-0190-8
language
English
LU publication?
yes
id
ebff351d-30e2-4466-9a5a-0092fb7d2781
date added to LUP
2017-05-19 08:39:04
date last changed
2017-09-18 11:36:22
@article{ebff351d-30e2-4466-9a5a-0092fb7d2781,
  abstract     = {<p>Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. Method: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged 7-70 years. A comprehensive examination of lung function was performed for all subjects. Principal component analyses and multiple regression analyses were used to explore the relationships between subject characteristics and particle deposition. Results: A large individual variability in respiratory tract deposition efficiency was found. Individuals with high deposition of a certain particle size generally had high deposition for all particles &lt;3500 nm. The individual variability was explained by two factors: breathing pattern, and lung structural and functional properties. The most important predictors were found to be breathing frequency and anatomical airway dead space. We also present a linear regression model describing the deposition based on four variables: tidal volume, breathing frequency, anatomical dead space and resistance of the respiratory system (the latter measured with impulse oscillometry). Conclusions: To understand why some individuals are more susceptible to airborne particles we must understand, and take into account, the individual variability in the probability of particles to deposit in the respiratory tract by considering not only breathing patterns but also adequate measures of relevant structural and functional properties.</p>},
  articleno    = {10},
  author       = {Rissler, Jenny and Gudmundsson, Anders and Nicklasson, Hanna and Swietlicki, Erik and Wollmer, Per and Löndahl, Jakob},
  issn         = {1743-8977},
  keyword      = {Aerosols,Airborne particles,Airway dead space,Individual variability,Inhalation,Lung dose,NanoSafety,Particle lung deposition,Respiratory tract deposition},
  language     = {eng},
  month        = {04},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Particle and Fibre Toxicology},
  title        = {Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function : An experimental study in healthy children and adults},
  url          = {http://dx.doi.org/10.1186/s12989-017-0190-8},
  volume       = {14},
  year         = {2017},
}