Replication of a Novel Parkinson's Locus in a European Ancestry Population
(2021) In Movement Disorders 36(7). p.1689-1695- Abstract
BACKGROUND: A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17.
OBJECTIVES: The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations.
METHODS: We report an association analysis of recently reported variants with PD in the COURAGE-PD cohort (9673 PD patients; 8465 controls) comprising individuals of European and East Asian ancestries. In addition, publicly available summary data (41,386 PD patients; 476,428 controls) were pooled.
RESULTS: Our findings confirmed the role of the SV2C variant in PD pathogenesis... (More)
BACKGROUND: A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17.
OBJECTIVES: The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations.
METHODS: We report an association analysis of recently reported variants with PD in the COURAGE-PD cohort (9673 PD patients; 8465 controls) comprising individuals of European and East Asian ancestries. In addition, publicly available summary data (41,386 PD patients; 476,428 controls) were pooled.
RESULTS: Our findings confirmed the role of the SV2C variant in PD pathogenesis (rs246814, COURAGE-PD PEuropean = 6.64 × 10-4 , pooled PD P = 1.15 × 10-11 ). The WBSCR17 rs9638616 was observed as a significant risk marker in the East Asian pooled population only (P = 1.16 × 10-8 ).
CONCLUSIONS: Our comprehensive study provides an up-to-date summary of recently detected novel loci in different PD populations and confirmed the role of SV2C locus as a novel risk factor for PD irrespective of the population or ethnic group analyzed. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
(Less)
- author
- contributor
- Puschmann, Andreas
LU
and Hellberg, Clara
LU
- author collaboration
- organization
- publishing date
- 2021-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Asian People/genetics, Cohort Studies, Ethnicity, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Humans, Parkinson Disease/genetics, Risk Factors
- in
- Movement Disorders
- volume
- 36
- issue
- 7
- pages
- 1689 - 1695
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85112487585
- pmid:33760272
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.28546
- language
- English
- LU publication?
- yes
- additional info
- © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
- id
- ec5104a4-9e7c-4017-96e7-49f87c680243
- date added to LUP
- 2023-08-31 21:20:21
- date last changed
- 2024-04-20 03:24:47
@article{ec5104a4-9e7c-4017-96e7-49f87c680243,
abstract = {{<p>BACKGROUND: A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17.</p><p>OBJECTIVES: The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations.</p><p>METHODS: We report an association analysis of recently reported variants with PD in the COURAGE-PD cohort (9673 PD patients; 8465 controls) comprising individuals of European and East Asian ancestries. In addition, publicly available summary data (41,386 PD patients; 476,428 controls) were pooled.</p><p>RESULTS: Our findings confirmed the role of the SV2C variant in PD pathogenesis (rs246814, COURAGE-PD PEuropean = 6.64 × 10-4 , pooled PD P = 1.15 × 10-11 ). The WBSCR17 rs9638616 was observed as a significant risk marker in the East Asian pooled population only (P = 1.16 × 10-8 ).</p><p>CONCLUSIONS: Our comprehensive study provides an up-to-date summary of recently detected novel loci in different PD populations and confirmed the role of SV2C locus as a novel risk factor for PD irrespective of the population or ethnic group analyzed. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>}},
author = {{Grover, Sandeep and Kumar-Sreelatha, Ashwin Ashok and Bobbili, Dheeraj R and May, Patrick and Domenighetti, Cloé and Sugier, Pierre-Emmanuel and Schulte, Claudia and Elbaz, Alexis and Krüger, Rejko and Gasser, Thomas and Sharma, Manu}},
issn = {{0885-3185}},
keywords = {{Asian People/genetics; Cohort Studies; Ethnicity; Genetic Predisposition to Disease/genetics; Genome-Wide Association Study; Humans; Parkinson Disease/genetics; Risk Factors}},
language = {{eng}},
number = {{7}},
pages = {{1689--1695}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Movement Disorders}},
title = {{Replication of a Novel Parkinson's Locus in a European Ancestry Population}},
url = {{http://dx.doi.org/10.1002/mds.28546}},
doi = {{10.1002/mds.28546}},
volume = {{36}},
year = {{2021}},
}