New theory to explain the effect of lactose fines on the performance of adhesive mixtures for inhalation
(2024) In International Journal of Pharmaceutics 663.- Abstract
A new theory for the dispersibility enhancing effect of excipient fines for adhesive mixtures for inhalation is presented in this paper, while at the same time the shortcomings of current hypotheses are discussed. The proposed mechanism, denoted the ‘viscoelastic damping effect’, states that the presence of fines particles acts to dampen the collisions between carrier particles during mixing. As a consequence, fewer fine particles are ‘irreversibly’ pressed into the carriers, which in turn entails a higher fine particle fraction. The mechanism was demonstrated experimentally at different levels of added lactose fines by studying the influence of processing on fine particle fraction. This approach furthermore enabled quantification of... (More)
A new theory for the dispersibility enhancing effect of excipient fines for adhesive mixtures for inhalation is presented in this paper, while at the same time the shortcomings of current hypotheses are discussed. The proposed mechanism, denoted the ‘viscoelastic damping effect’, states that the presence of fines particles acts to dampen the collisions between carrier particles during mixing. As a consequence, fewer fine particles are ‘irreversibly’ pressed into the carriers, which in turn entails a higher fine particle fraction. The mechanism was demonstrated experimentally at different levels of added lactose fines by studying the influence of processing on fine particle fraction. This approach furthermore enabled quantification of the effect. All fine particles present in the blend (APIs and excipient fines) act together to exert the damping effect. The proposed mechanism is able to explain the main body of published data, including the effect of added excipient fines, the effect of an increased drug load, and the effect of removal of carrier fines. The viscoelastic damping mechanism is general in nature and conveys a broader and more general understanding of the behavior of adhesive mixtures for inhalation.
(Less)
- author
- Thalberg, Kyrre LU
- organization
- publishing date
- 2024-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adhesive mixture, Effective mixing force, Fine particle fraction, Inhalation, Lactose fines effect, Viscoelastic damping
- in
- International Journal of Pharmaceutics
- volume
- 663
- article number
- 124549
- publisher
- Elsevier
- external identifiers
-
- pmid:39128621
- scopus:85201144155
- ISSN
- 0378-5173
- DOI
- 10.1016/j.ijpharm.2024.124549
- language
- English
- LU publication?
- yes
- id
- ec700003-6b16-4829-b8e5-93c38cfd0b48
- date added to LUP
- 2024-09-06 13:24:40
- date last changed
- 2024-10-18 19:07:14
@article{ec700003-6b16-4829-b8e5-93c38cfd0b48,
abstract = {{<p>A new theory for the dispersibility enhancing effect of excipient fines for adhesive mixtures for inhalation is presented in this paper, while at the same time the shortcomings of current hypotheses are discussed. The proposed mechanism, denoted the ‘viscoelastic damping effect’, states that the presence of fines particles acts to dampen the collisions between carrier particles during mixing. As a consequence, fewer fine particles are ‘irreversibly’ pressed into the carriers, which in turn entails a higher fine particle fraction. The mechanism was demonstrated experimentally at different levels of added lactose fines by studying the influence of processing on fine particle fraction. This approach furthermore enabled quantification of the effect. All fine particles present in the blend (APIs and excipient fines) act together to exert the damping effect. The proposed mechanism is able to explain the main body of published data, including the effect of added excipient fines, the effect of an increased drug load, and the effect of removal of carrier fines. The viscoelastic damping mechanism is general in nature and conveys a broader and more general understanding of the behavior of adhesive mixtures for inhalation.</p>}},
author = {{Thalberg, Kyrre}},
issn = {{0378-5173}},
keywords = {{Adhesive mixture; Effective mixing force; Fine particle fraction; Inhalation; Lactose fines effect; Viscoelastic damping}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{International Journal of Pharmaceutics}},
title = {{New theory to explain the effect of lactose fines on the performance of adhesive mixtures for inhalation}},
url = {{http://dx.doi.org/10.1016/j.ijpharm.2024.124549}},
doi = {{10.1016/j.ijpharm.2024.124549}},
volume = {{663}},
year = {{2024}},
}