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Reduction of Streptococcus pneumoniae in upper respiratory tract cultures and a decreased incidence of related acute otitis media following introduction of childhood pneumococcal conjugate vaccines in a Swedish county

Littorin, Nils LU ; Ahl, Jonas LU ; Uddén, Fabian LU orcid ; Resman, Fredrik LU and Riesbeck, Kristian LU orcid (2016) In BMC Infectious Diseases 16(1).
Abstract

Background: The effect of pneumococcal conjugate vaccines (PCV) on invasive pneumococcal disease is frequently reported, but the impact on upper respiratory tract infections in a clinical setting is less documented. Our aim in this 5-year observational study was to investigate serotype changes in a large number of Streptococcus pneumoniae upper respiratory tract isolates following sequential introduction of PCV7 and pneumococcal Haemophilus influenza protein D conjugate vaccine (PHiD-CV10) in a Swedish county. Methods: All bacterial isolates from the upper respiratory tract (nasopharynx, sinus or middle ear fluid) from patients with respiratory tract infections referred to a clinical microbiology laboratory prior to (2 years 2007-2008;... (More)

Background: The effect of pneumococcal conjugate vaccines (PCV) on invasive pneumococcal disease is frequently reported, but the impact on upper respiratory tract infections in a clinical setting is less documented. Our aim in this 5-year observational study was to investigate serotype changes in a large number of Streptococcus pneumoniae upper respiratory tract isolates following sequential introduction of PCV7 and pneumococcal Haemophilus influenza protein D conjugate vaccine (PHiD-CV10) in a Swedish county. Methods: All bacterial isolates from the upper respiratory tract (nasopharynx, sinus or middle ear fluid) from patients with respiratory tract infections referred to a clinical microbiology laboratory prior to (2 years 2007-2008; n = 1566) and after introduction of PCV (3 years 2011-2013; n = 1707) were prospectively collected. Microbiological findings were compared between the two periods, and information from clinical referrals was recorded in order to explore changes in incidence of pneumococcal acute otitis media (AOM). Results: Pneumococcal serotypes covered by PHiD-CV10 decreased from 45 to 12 % prior to and after immunization (p < 0.001), respectively. Despite non-PHiD-CV10 serotypes increased from 49 to 80 %, a significant decline of 35 % in the absolute incidence of pneumocococal isolates (p < 0.001) was observed. Finally, the frequency of complicated AOM caused by S. pneumoniae decreased by 32 % (p < 0.001). Conclusions: After introduction of PCV in 2009, we have observed a significantly decreased number of pneumococcal isolates in the upper respiratory tract, a shift to non-PHiD-CV10 serotypes, and a reduction of complicated AOM. Our findings may have implications for future vaccine design.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Otitis media, Pneumococcal vaccines, Serogroup, Streptococcus pneumoniae
in
BMC Infectious Diseases
volume
16
issue
1
article number
407
publisher
BioMed Central (BMC)
external identifiers
  • wos:000381348000008
  • pmid:27514843
  • scopus:84991768926
ISSN
1471-2334
DOI
10.1186/s12879-016-1750-5
project
Streptococcus pneumoniae – epidemiology and host interactions in the conjugate vaccine era
Bacterial respiratory tract infections - aspects on virulence, epidemiology and future vaccines
language
English
LU publication?
yes
id
ec85a6e7-ff4c-4d52-bda5-72e66ad908cb
date added to LUP
2016-11-04 13:29:41
date last changed
2025-01-12 14:16:13
@article{ec85a6e7-ff4c-4d52-bda5-72e66ad908cb,
  abstract     = {{<p>Background: The effect of pneumococcal conjugate vaccines (PCV) on invasive pneumococcal disease is frequently reported, but the impact on upper respiratory tract infections in a clinical setting is less documented. Our aim in this 5-year observational study was to investigate serotype changes in a large number of Streptococcus pneumoniae upper respiratory tract isolates following sequential introduction of PCV7 and pneumococcal Haemophilus influenza protein D conjugate vaccine (PHiD-CV10) in a Swedish county. Methods: All bacterial isolates from the upper respiratory tract (nasopharynx, sinus or middle ear fluid) from patients with respiratory tract infections referred to a clinical microbiology laboratory prior to (2 years 2007-2008; n = 1566) and after introduction of PCV (3 years 2011-2013; n = 1707) were prospectively collected. Microbiological findings were compared between the two periods, and information from clinical referrals was recorded in order to explore changes in incidence of pneumococcal acute otitis media (AOM). Results: Pneumococcal serotypes covered by PHiD-CV10 decreased from 45 to 12 % prior to and after immunization (p &lt; 0.001), respectively. Despite non-PHiD-CV10 serotypes increased from 49 to 80 %, a significant decline of 35 % in the absolute incidence of pneumocococal isolates (p &lt; 0.001) was observed. Finally, the frequency of complicated AOM caused by S. pneumoniae decreased by 32 % (p &lt; 0.001). Conclusions: After introduction of PCV in 2009, we have observed a significantly decreased number of pneumococcal isolates in the upper respiratory tract, a shift to non-PHiD-CV10 serotypes, and a reduction of complicated AOM. Our findings may have implications for future vaccine design.</p>}},
  author       = {{Littorin, Nils and Ahl, Jonas and Uddén, Fabian and Resman, Fredrik and Riesbeck, Kristian}},
  issn         = {{1471-2334}},
  keywords     = {{Otitis media; Pneumococcal vaccines; Serogroup; Streptococcus pneumoniae}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Infectious Diseases}},
  title        = {{Reduction of Streptococcus pneumoniae in upper respiratory tract cultures and a decreased incidence of related acute otitis media following introduction of childhood pneumococcal conjugate vaccines in a Swedish county}},
  url          = {{http://dx.doi.org/10.1186/s12879-016-1750-5}},
  doi          = {{10.1186/s12879-016-1750-5}},
  volume       = {{16}},
  year         = {{2016}},
}