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Assessment of a hand-held CZT-based gamma camera for pre-clinical imaging of 177Lu

Roth, Daniel LU orcid ; Ljungberg, Michael LU and Strand, Sven-Erik LU (2023) 2023 IEEE Nuclear Science Symposium and Medical Imaging Conference
Abstract
A small CdZnTe-based hand-held gamma-camera has been acquired, intended to be used for preclinical imaging. The camera produces images of size 4 cm x 4 cm with an image-matrix of 16 x 16 pixels and can be equipped with a low-energy high-sensitivity (LEHS) or a high-resolution (LEHR) parallel-hole collimator. Pre-clinical imaging involves scales smaller than what the camera is typically used for, and dedicated assessment of the camera’s performance in this field is thus warranted and the aim of this work. To this end, a mouse-like phantom is developed with the MOBY computer phantom as a basis and manufactured through 3D-printing. The phantom is printed in PLA, with fillable cavities for the liver and a tumour. Additionally, a motorised... (More)
A small CdZnTe-based hand-held gamma-camera has been acquired, intended to be used for preclinical imaging. The camera produces images of size 4 cm x 4 cm with an image-matrix of 16 x 16 pixels and can be equipped with a low-energy high-sensitivity (LEHS) or a high-resolution (LEHR) parallel-hole collimator. Pre-clinical imaging involves scales smaller than what the camera is typically used for, and dedicated assessment of the camera’s performance in this field is thus warranted and the aim of this work. To this end, a mouse-like phantom is developed with the MOBY computer phantom as a basis and manufactured through 3D-printing. The phantom is printed in PLA, with fillable cavities for the liver and a tumour. Additionally, a motorised platform is built enabling SPECT acquisitions by rotating an object in front of the camera. Software is developed in-house for camera operation, SPECT acquisition, and tomographic reconstruction. The camera’s performance for 177 Lu imaging is assessed through measurements on the imageuniformity, sensitivity, spatial resolution, as well as planar and SPECT acquisitions on the mouse phantom. Energy windows over the 55 keV, 113 keV, and 208 keV photopeaks are investigated. Obtained sensitivities are around 100 cps/MBq for the LEHS collimator and 20 cps/MBq for the LEHR collimator, meaning that quick acquisitions can be made with 177 Lu activity administrations that are typically used pre-clinically. Tomographic reconstructions demonstrates that the camera can be used for SPECT applications. Overall, the camera is found promising for pre-clinical applications, both for planar and SPECT imaging. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to conference
publication status
published
subject
conference name
2023 IEEE Nuclear Science Symposium and Medical Imaging Conference
conference location
Vancouver, Canada
conference dates
2023-11-04 - 2023-11-11
DOI
10.1109/NSSMICRTSD49126.2023.10338278
project
Metoder för strålningsdosimetri inom preklinisk radionuklidterapi
language
English
LU publication?
yes
id
eca06b3f-ee54-4c15-a6be-060b89dd39f5
date added to LUP
2024-03-27 16:22:10
date last changed
2024-03-28 11:02:04
@misc{eca06b3f-ee54-4c15-a6be-060b89dd39f5,
  abstract     = {{A small CdZnTe-based hand-held gamma-camera has been acquired, intended to be used for preclinical imaging. The camera produces images of size 4 cm x 4 cm with an image-matrix of 16 x 16 pixels and can be equipped with a low-energy high-sensitivity (LEHS) or a high-resolution (LEHR) parallel-hole collimator. Pre-clinical imaging involves scales smaller than what the camera is typically used for, and dedicated assessment of the camera’s performance in this field is thus warranted and the aim of this work. To this end, a mouse-like phantom is developed with the MOBY computer phantom as a basis and manufactured through 3D-printing. The phantom is printed in PLA, with fillable cavities for the liver and a tumour. Additionally, a motorised platform is built enabling SPECT acquisitions by rotating an object in front of the camera. Software is developed in-house for camera operation, SPECT acquisition, and tomographic reconstruction. The camera’s performance for 177 Lu imaging is assessed through measurements on the imageuniformity, sensitivity, spatial resolution, as well as planar and SPECT acquisitions on the mouse phantom. Energy windows over the 55 keV, 113 keV, and 208 keV photopeaks are investigated. Obtained sensitivities are around 100 cps/MBq for the LEHS collimator and 20 cps/MBq for the LEHR collimator, meaning that quick acquisitions can be made with 177 Lu activity administrations that are typically used pre-clinically. Tomographic reconstructions demonstrates that the camera can be used for SPECT applications. Overall, the camera is found promising for pre-clinical applications, both for planar and SPECT imaging.}},
  author       = {{Roth, Daniel and Ljungberg, Michael and Strand, Sven-Erik}},
  language     = {{eng}},
  month        = {{10}},
  title        = {{Assessment of a hand-held CZT-based gamma camera for pre-clinical imaging of <sup>177</sup>Lu}},
  url          = {{http://dx.doi.org/10.1109/NSSMICRTSD49126.2023.10338278}},
  doi          = {{10.1109/NSSMICRTSD49126.2023.10338278}},
  year         = {{2023}},
}