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Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark

Borggren, Marie LU ; Jensen, Sanne Skov ; Heyndrickx, Leo ; Palm, Angelica A. LU ; Gerstoft, Jan ; Kronborg, Gitte ; Hønge, Bo Langhoff ; Jespersen, Sanne ; Da Silva, Zacarias José and Karlsson, Ingrid LU , et al. (2016) In AIDS Research and Human Retroviruses 32(5). p.434-442
Abstract

The development of therapeutic and prophylactic HIV vaccines for African countries is urgently needed, but the question of what immunogens to use needs to be answered. One approach is to include HIV envelope immunogens derived from HIV-positive individuals from a geographically concentrated epidemic with more limited viral genetic diversity for a region-based vaccine. To address if there is a basis for a regional selected antibody vaccine, we have screened two regionally separate cohorts from Guinea-Bissau and Denmark for neutralizing antibody activity and antibody-dependent cellular cytotoxicity (ADCC) against local and nonlocal circulating HIV-1 strains. The neutralizing activity did not demonstrate higher potential against local... (More)

The development of therapeutic and prophylactic HIV vaccines for African countries is urgently needed, but the question of what immunogens to use needs to be answered. One approach is to include HIV envelope immunogens derived from HIV-positive individuals from a geographically concentrated epidemic with more limited viral genetic diversity for a region-based vaccine. To address if there is a basis for a regional selected antibody vaccine, we have screened two regionally separate cohorts from Guinea-Bissau and Denmark for neutralizing antibody activity and antibody-dependent cellular cytotoxicity (ADCC) against local and nonlocal circulating HIV-1 strains. The neutralizing activity did not demonstrate higher potential against local circulating strains according to geography and subtype determination, but the plasma from Danish individuals demonstrated significantly higher inhibitory activity than that from Guinea-Bissau individuals against both local and nonlocal virus strains. Interestingly, an opposite pattern was observed with ADCC activity, where Guinea-Bissau individual plasma demonstrated higher activity than Danish plasma and was specifically against the local circulating subtype. Thus, on basis of samples from these two cohorts, no local-specific neutralizing activity was detected, but a local ADCC response was identified in the Guinea-Bissau samples, suggesting potential use of regional immunogens for an ADCC-inducing vaccine.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
AIDS Research and Human Retroviruses
volume
32
issue
5
pages
9 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:84966668342
  • wos:000374828900005
ISSN
0889-2229
DOI
10.1089/aid.2015.0118
language
English
LU publication?
yes
id
ecaa74c3-6260-4e30-8b59-3038439e3879
date added to LUP
2016-06-01 10:50:53
date last changed
2025-01-12 06:48:28
@article{ecaa74c3-6260-4e30-8b59-3038439e3879,
  abstract     = {{<p>The development of therapeutic and prophylactic HIV vaccines for African countries is urgently needed, but the question of what immunogens to use needs to be answered. One approach is to include HIV envelope immunogens derived from HIV-positive individuals from a geographically concentrated epidemic with more limited viral genetic diversity for a region-based vaccine. To address if there is a basis for a regional selected antibody vaccine, we have screened two regionally separate cohorts from Guinea-Bissau and Denmark for neutralizing antibody activity and antibody-dependent cellular cytotoxicity (ADCC) against local and nonlocal circulating HIV-1 strains. The neutralizing activity did not demonstrate higher potential against local circulating strains according to geography and subtype determination, but the plasma from Danish individuals demonstrated significantly higher inhibitory activity than that from Guinea-Bissau individuals against both local and nonlocal virus strains. Interestingly, an opposite pattern was observed with ADCC activity, where Guinea-Bissau individual plasma demonstrated higher activity than Danish plasma and was specifically against the local circulating subtype. Thus, on basis of samples from these two cohorts, no local-specific neutralizing activity was detected, but a local ADCC response was identified in the Guinea-Bissau samples, suggesting potential use of regional immunogens for an ADCC-inducing vaccine.</p>}},
  author       = {{Borggren, Marie and Jensen, Sanne Skov and Heyndrickx, Leo and Palm, Angelica A. and Gerstoft, Jan and Kronborg, Gitte and Hønge, Bo Langhoff and Jespersen, Sanne and Da Silva, Zacarias José and Karlsson, Ingrid and Fomsgaard, Anders}},
  issn         = {{0889-2229}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{434--442}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{AIDS Research and Human Retroviruses}},
  title        = {{Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark}},
  url          = {{http://dx.doi.org/10.1089/aid.2015.0118}},
  doi          = {{10.1089/aid.2015.0118}},
  volume       = {{32}},
  year         = {{2016}},
}