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Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort

Schlesinger, Sabrina; Aleksandrova, Krasimira; Pischon, Tobias; Fedirko, Veronika; Jenab, Mazda; Trepo, Elisabeth; Boffetta, Paolo; Dahm, Christina C.; Overvad, Kim and Tjonneland, Anne, et al. (2013) In International Journal of Cancer 132(3). p.645-657
Abstract
General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested casecontrol subset. During a mean... (More)
General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested casecontrol subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.095.87; ptrend < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.122.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.494.13; <0.001). No statistically significant association was observed between obesity and risk of IBDC and EBDSC. Our results provide evidence of an association between obesity, particularly abdominal obesity, and risk of HCC and GBC. Our findings support public health recommendations to reduce the prevalence of obesity and weight gain in adulthood for HCC and GBC prevention in Western populations. (Less)
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published
subject
keywords
liver neoplasms, hepatocellular carcinoma, biliary tract neoplasms, obesity, abdominal fat, weight change
in
International Journal of Cancer
volume
132
issue
3
pages
645 - 657
publisher
John Wiley & Sons
external identifiers
  • wos:000311620100022
  • scopus:84870251301
ISSN
0020-7136
DOI
10.1002/ijc.27645
language
English
LU publication?
yes
id
ecd2cc33-d62f-4bc8-b911-19cb0b87093e (old id 3401136)
date added to LUP
2013-02-01 07:06:59
date last changed
2019-02-20 02:57:54
@article{ecd2cc33-d62f-4bc8-b911-19cb0b87093e,
  abstract     = {General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested casecontrol subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.095.87; ptrend &lt; 0.0001] and with GBC (RR: 1.56, 95% CI: 1.122.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.494.13; &lt;0.001). No statistically significant association was observed between obesity and risk of IBDC and EBDSC. Our results provide evidence of an association between obesity, particularly abdominal obesity, and risk of HCC and GBC. Our findings support public health recommendations to reduce the prevalence of obesity and weight gain in adulthood for HCC and GBC prevention in Western populations.},
  author       = {Schlesinger, Sabrina and Aleksandrova, Krasimira and Pischon, Tobias and Fedirko, Veronika and Jenab, Mazda and Trepo, Elisabeth and Boffetta, Paolo and Dahm, Christina C. and Overvad, Kim and Tjonneland, Anne and Halkjaer, Jytte and Fagherazzi, Guy and Boutron-Ruault, Marie-Christine and Carbonnel, Franck and Kaaks, Rudolf and Lukanova, Annekatrin and Boeing, Heiner and Trichopoulou, Antonia and Bamia, Christina and Lagiou, Pagona and Palli, Domenico and Grioni, Sara and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and Bueno-de-Mesquita, H. B. and van den Berg, Saskia and Peeters, Petra H. M. and Braaten, Tonje and Weiderpass, Elisabete and Quiros, J. Ramon and Travier, Noemie and Sanchez, Maria-Jose and Navarro, Carmen and Barricarte, Aurelio and Dorronsoro, Miren and Lindkvist, Björn and Regnér, Sara and Werner, Marten and Sund, Malin and Khaw, Kay-Tee and Wareham, Nicholas and Travis, Ruth C. and Norat, Teresa and Wark, Petra A. and Riboli, Elio and Nothlings, Ute},
  issn         = {0020-7136},
  keyword      = {liver neoplasms,hepatocellular carcinoma,biliary tract neoplasms,obesity,abdominal fat,weight change},
  language     = {eng},
  number       = {3},
  pages        = {645--657},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort},
  url          = {http://dx.doi.org/10.1002/ijc.27645},
  volume       = {132},
  year         = {2013},
}